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dc.contributor.author | Quintero-Campos, Pedro | es_ES |
dc.contributor.author | Juárez-Rodríguez, María José | es_ES |
dc.contributor.author | Morais, Sergi | es_ES |
dc.contributor.author | Maquieira Catala, Ángel | es_ES |
dc.date.accessioned | 2021-05-04T03:32:07Z | |
dc.date.available | 2021-05-04T03:32:07Z | |
dc.date.issued | 2020-11-03 | es_ES |
dc.identifier.issn | 0003-2700 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/165906 | |
dc.description | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Analytical Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.analchem.0c03020 | es_ES |
dc.description.abstract | [EN] beta-lactams (BLCs) are the most widely used antibiotics and consequently the most common cause of drug allergy in the world. The diagnosis of drug allergy is complex and represents a serious challenge that includes a wide variety of methods. In vitro tests are based on the immunological determination of allergen-specific IgE, but the tests in the market lack the required sensitivity and specificity. In addition, the large sample volume, long incubation times, and single-plex configuration have brought their use into question to complement the clinical information. Here, we report a chemiluminescence immunoassay (CLIA) for multiparametric quantification of specific IgE to penicillin G, penicillin V, amoxicillin, and piperacillin, using histone H1 as a carrier. The developed CLIA allowed the determination of BLC-specific IgE below 0.1 IU/mL, thus allowing identification of allergic patients with better sensitivity, using only 25 mu L of a sample (serum). The immunoassay was successfully applied in a cohort of 140 human serum samples, showing good sensitivity (64.6%) as well as specificity (100%), which significantly improve the predictive character of existing BLC-allergy in vitro tests. | es_ES |
dc.description.sponsorship | P.Q.C. acknowledges financial support from Generalitat Valenciana through the research staff-training program (GVA ACIF/2018/173). This research has been funded by the H2020 Program (project COBIOPHAD, grant agreement No. 688448), which is an initiative of the Photonics PPP (www.photonics21.org). | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | American Chemical Society | es_ES |
dc.relation.ispartof | Analytical Chemistry | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject.classification | QUIMICA ANALITICA | es_ES |
dc.subject.classification | QUIMICA INORGANICA | es_ES |
dc.title | Multiparametric Highly Sensitive Chemiluminescence Immunoassayfor Quantification of b-Lactam-Specific Immunoglobulin E | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1021/acs.analchem.0c03020 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/688448/EU/COMPACT BIOPHOTONIC PLATFORM FOR DRUG ALLERGY DIAGNOSIS/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/GVA//ACIF%2F2018%2F173/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Química - Departament de Química | es_ES |
dc.description.bibliographicCitation | Quintero-Campos, P.; Juárez-Rodríguez, MJ.; Morais, S.; Maquieira Catala, Á. (2020). Multiparametric Highly Sensitive Chemiluminescence Immunoassayfor Quantification of b-Lactam-Specific Immunoglobulin E. Analytical Chemistry. 92(21):14608-14615. https://doi.org/10.1021/acs.analchem.0c03020 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.1021/acs.analchem.0c03020 | es_ES |
dc.description.upvformatpinicio | 14608 | es_ES |
dc.description.upvformatpfin | 14615 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 92 | es_ES |
dc.description.issue | 21 | es_ES |
dc.identifier.pmid | 33089686 | es_ES |
dc.relation.pasarela | S\419904 | es_ES |
dc.contributor.funder | Generalitat Valenciana | es_ES |
dc.contributor.funder | European Commission | es_ES |
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