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Elastomeric cardiopatch scaffold for myocardial repair and ventricular support

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Elastomeric cardiopatch scaffold for myocardial repair and ventricular support

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dc.contributor.author Chachques, Juan Carlos es_ES
dc.contributor.author Lila, Nermine es_ES
dc.contributor.author Soler Botija, Carolina es_ES
dc.contributor.author Martínez-Ramos, Cristina es_ES
dc.contributor.author Vallés Lluch, Ana es_ES
dc.contributor.author Autret, Gwennhael es_ES
dc.contributor.author Perier, Marie-Cecile es_ES
dc.contributor.author Mirochnik, Nicolas es_ES
dc.contributor.author Monleón Pradas, Manuel es_ES
dc.contributor.author Bayes-Genis, Antoni es_ES
dc.contributor.author Semino, Carlos E. es_ES
dc.date.accessioned 2021-05-14T12:40:48Z
dc.date.available 2021-05-14T12:40:48Z
dc.date.issued 2020-03 es_ES
dc.identifier.issn 1010-7940 es_ES
dc.identifier.uri http://hdl.handle.net/10251/166365
dc.description.abstract [EN] OBJECTIVES: Prevention of postischaemic ventricular dilatation progressing towards pathological remodelling is necessary to decrease ventricular wall deterioration. Myocardial tissue engineering may play a therapeutic role due to its capacity to replace the extracellular matrix, thereby creating niches for cell homing. In this experimental animal study, a biomimetic cardiopatch was created with elastomeric scaffolds and nanotechnologies. METHODS: In an experimental animal study in 18 sheep, a cardiopatch was created with adipose tissue-derived progenitor cells seeded into an engineered bioimplant consisting of 3-dimensional bioabsorbable polycaprolactone scaffolds filled with a peptide hydrogel (PuraMatrix (TM)). This patch was then transplanted to cover infarcted myocardium. Non-absorbable poly(ethyl) acrylate polymer scaffolds were used as controls. RESULTS: Fifteen sheep were followed with ultrasound scans at 6 months, including echocardiography scans, tissue Doppler and spectral flow analysis and speckle-tracking imaging, which showed a reduction in longitudinal left ventricular deformation in the cardiopatch-treated group. Magnetic resonance imaging (late gadolinium enhancement) showed reduction of infarct size relative to left ventricular mass in the cardiopatch group versus the controls. Histopathological analysis at 6 months showed that the cardiopatch was fully anchored and integrated to the infarct area with minimal fibrosis interface, thereby promoting angiogenesis and migration of adipose tissue-derived progenitor cells to surrounding tissues. CONCLUSIONS: This study shows the feasibility and effectiveness of a cardiopatch grafted onto myocardial infarction scars in an experimental animal model. This treatment decreased fibrosis, limited infarct scar expansion and reduced postischaemic ventricular deformity. A capillary network developed between our scaffold and the heart. The elastomeric cardiopatch seems to have a positive impact on ventricular remodelling and performance in patients with heart failure. es_ES
dc.description.sponsorship The RECATABI Project (Regeneration of Cardiac Tissue Assisted by Bioactive Implants) was financially supported by the 7th Framework Programme (FP7) of the European Commission. Project ID: 229239. Funded under FP7-NMP and the European Regional Development Fund (FEDER Spain). es_ES
dc.language Inglés es_ES
dc.publisher Oxford University Press es_ES
dc.relation.ispartof European Journal of Cardio-Thoracic Surgery es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Heart failure es_ES
dc.subject Cardiac tissue engineering es_ES
dc.subject Elastomeric scaffold es_ES
dc.subject Cardiopatch es_ES
dc.subject Cardiowrap es_ES
dc.subject Translational and clinical research es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title Elastomeric cardiopatch scaffold for myocardial repair and ventricular support es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1093/ejcts/ezz252 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/229239/EU/Regeneration of Cardiac Tissue Assisted by Bioactive Implants/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.description.bibliographicCitation Chachques, JC.; Lila, N.; Soler Botija, C.; Martínez-Ramos, C.; Vallés Lluch, A.; Autret, G.; Perier, M.... (2020). Elastomeric cardiopatch scaffold for myocardial repair and ventricular support. European Journal of Cardio-Thoracic Surgery. 57(3):545-555. https://doi.org/10.1093/ejcts/ezz252 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1093/ejcts/ezz252 es_ES
dc.description.upvformatpinicio 545 es_ES
dc.description.upvformatpfin 555 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 57 es_ES
dc.description.issue 3 es_ES
dc.identifier.pmid 31539050 es_ES
dc.relation.pasarela S\404716 es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder European Commission es_ES
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