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Incubation of neural alcohol cue reactivity after withdrawal and its blockade by naltrexone

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Incubation of neural alcohol cue reactivity after withdrawal and its blockade by naltrexone

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dc.contributor.author Bach, Patrick es_ES
dc.contributor.author Weil, Georg es_ES
dc.contributor.author Pompili, Enrico es_ES
dc.contributor.author Hoffmann, Sabine es_ES
dc.contributor.author Hermann, Derik es_ES
dc.contributor.author Vollstädt-Klein, Sabine es_ES
dc.contributor.author Mann, Karl es_ES
dc.contributor.author Pérez-Ramírez, Úrsula es_ES
dc.contributor.author Moratal, David es_ES
dc.contributor.author Canals, Santiago es_ES
dc.contributor.author Dursun, Serdar M. es_ES
dc.contributor.author Greenshaw, Andrew J. es_ES
dc.contributor.author Kirsch, Peter es_ES
dc.contributor.author Kiefer, Falk es_ES
dc.contributor.author Sommer, Wolfgang H. es_ES
dc.date.accessioned 2021-05-20T03:34:18Z
dc.date.available 2021-05-20T03:34:18Z
dc.date.issued 2020-01 es_ES
dc.identifier.issn 1355-6215 es_ES
dc.identifier.uri http://hdl.handle.net/10251/166535
dc.description.abstract [EN] During the first weeks of abstinence, alcohol craving in patients may increase or "incubate." We hypothesize that Naltrexone (NTX) blocks this incubation effect. Here, we compared NTX effects on neural alcohol cue reactivity (CR) over the first weeks of abstinence and on long-term clinical outcomes to standard treatment. Male alcohol-dependent patients (n = 55) and healthy controls (n = 35) were enrolled. Participants underwent baseline psychometric testing and functional magnetic resonance imaging (fMRI) assessment of mesolimbic alcohol CR. Patients participated in a standard treatment program with the option of adjuvant NTX. They received another scan after 2 weeks of treatment. We found higher CR in several brain regions in patients versus healthy controls. CR significantly increased over 2 weeks in the standard treatment group (n = 13) but not in the NTX group (n = 22). NTX significantly attenuated CR in the left putamen and reduced relapse risk to heavy drinking within 3 months of treatment. Additionally, increased CR in the left putamen and its course over time predicted both NTX response and relapse risk. Carrier status for the functional OPRM1 variant rs1799971:A > G was considered but had no effect on NTX efficacy. In conclusion, NTX was most effective in patients with high CR in the left putamen. While the results from our naturalistic study await further confirmation from prospective randomized trials, they support a potential role of neural CR as a biomarker in the development of precision medicine approaches with NTX. es_ES
dc.description.sponsorship Deutsche Forschungsgemeinschaft, Grant/Award Number: SFB636; Horizon 2020 Framework Programme, Grant/Award Number: 668863-SyBil-AA; ERA-Net NEURON program, Grant/Award Number: FKZ 01EW1112-TRANSALC; European Union's Horizon 2020 research and innovation program, Grant/Award Number: 668863-SyBil-AA es_ES
dc.language Inglés es_ES
dc.publisher Blackwell Publishing es_ES
dc.relation.ispartof Addiction Biology es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Alcohol addiction es_ES
dc.subject Cue reactivity es_ES
dc.subject FMRI es_ES
dc.subject Naltrexone es_ES
dc.subject Relapse es_ES
dc.subject.classification TECNOLOGIA ELECTRONICA es_ES
dc.title Incubation of neural alcohol cue reactivity after withdrawal and its blockade by naltrexone es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1111/adb.12717 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/668863/EU/Systems Biology of Alcohol Addiction: Modeling and validating disease state networks in human and animal brains for understanding pathophysiolgy, predicting outcomes and improving therapy/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/DFG//SFB 636/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC//FKZ 01EW1112-TRANSALC/ es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica es_ES
dc.description.bibliographicCitation Bach, P.; Weil, G.; Pompili, E.; Hoffmann, S.; Hermann, D.; Vollstädt-Klein, S.; Mann, K.... (2020). Incubation of neural alcohol cue reactivity after withdrawal and its blockade by naltrexone. Addiction Biology. 25(1):1-11. https://doi.org/10.1111/adb.12717 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1111/adb.12717 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 11 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 25 es_ES
dc.description.issue 1 es_ES
dc.identifier.pmid 30748046 es_ES
dc.relation.pasarela S\427151 es_ES
dc.contributor.funder European Commission es_ES
dc.contributor.funder Deutsche Forschungsgemeinschaft es_ES
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dc.subject.ods 03.- Garantizar una vida saludable y promover el bienestar para todos y todas en todas las edades es_ES


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