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Cost-utility model of brivaracetam in the adjunctive treatment of patients with epilepsy in Spain

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Cost-utility model of brivaracetam in the adjunctive treatment of patients with epilepsy in Spain

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dc.contributor.author Barrachina Martínez, Isabel es_ES
dc.contributor.author Vivas-Consuelo, David es_ES
dc.contributor.author Reyes-Santias, Francisco es_ES
dc.date.accessioned 2021-05-25T03:32:31Z
dc.date.available 2021-05-25T03:32:31Z
dc.date.issued 2020-11-06 es_ES
dc.identifier.uri http://hdl.handle.net/10251/166746
dc.description.abstract [EN] Objective This study aims to assess the cost utility of Brivaracetam compared with the third-generation anti-epileptic drugs used as standard care. Methods A cost utility analysis of Brivaracetam was carried out with other third-generation comparators. The treatment pathway of a hypothetical cohort over a period of 2 years was simulated using the Markov model. Data for effectiveness and the QALYs of each health status for epilepsy, as well as for the disutilities of adverse events of treatments, were analyzed through a studies review. The cost of the anti-epileptics and the use of medical resources linked to the different health statuses were taken into consideration. A probabilistic sensitivity analysis was performed using a Monte Carlo simulation. Results Brivaracetam was shown to be the dominant alternative, with Incremental Cost Utility Ratio (ICUR) values from -11,318 for Lacosamide to -128,482 for Zonisamide. The probabilistic sensitivity analysis validates these results. The ICUR sensitivity is greater for increases in the price of Brivaracetam than for decreases, and for Eslicarbizapine over the other adjunctives considered in the analysis. Conclusions Treatment with Brivaracetam resulted in cost effective and incremental quality adjusted life years come at an acceptable cost. es_ES
dc.language Inglés es_ES
dc.publisher Taylor & Francis es_ES
dc.relation.ispartof Expert review of pharmacoeconomics & outcomes research (Online) es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Adjunctive therapy es_ES
dc.subject Anti-epileptic drugs es_ES
dc.subject Cost utility es_ES
dc.subject Markov model es_ES
dc.subject Monte Carlo simulation es_ES
dc.subject.classification ECONOMIA APLICADA es_ES
dc.subject.classification ECONOMIA FINANCIERA Y CONTABILIDAD es_ES
dc.title Cost-utility model of brivaracetam in the adjunctive treatment of patients with epilepsy in Spain es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1080/14737167.2021.1838899 es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Economía y Ciencias Sociales - Departament d'Economia i Ciències Socials es_ES
dc.description.bibliographicCitation Barrachina Martínez, I.; Vivas-Consuelo, D.; Reyes-Santias, F. (2020). Cost-utility model of brivaracetam in the adjunctive treatment of patients with epilepsy in Spain. Expert review of pharmacoeconomics & outcomes research (Online). 1-10. https://doi.org/10.1080/14737167.2021.1838899 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1080/14737167.2021.1838899 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 10 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.identifier.eissn 1744-8379 es_ES
dc.identifier.pmid 33074031 es_ES
dc.relation.pasarela S\421035 es_ES
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dc.subject.ods 03.- Garantizar una vida saludable y promover el bienestar para todos y todas en todas las edades es_ES


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