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Relevance of Nrf2 and heme oxygenase-1 in articular diseases

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Relevance of Nrf2 and heme oxygenase-1 in articular diseases

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dc.contributor.author Alcaraz Tormo, María José es_ES
dc.contributor.author Ferrándiz Manglano, María Luisa es_ES
dc.date.accessioned 2021-05-28T03:34:02Z
dc.date.available 2021-05-28T03:34:02Z
dc.date.issued 2020-09 es_ES
dc.identifier.issn 0891-5849 es_ES
dc.identifier.uri http://hdl.handle.net/10251/166910
dc.description.abstract [EN] Joint conditions pose an important public health problem as they are a leading cause of pain, functional limitation and physical disability. Oxidative stress is related to the pathogenesis of many chronic diseases affecting the joints such as rheumatoid arthritis and osteoarthritis. Cells have developed adaptive protection mechanisms to maintain homeostasis such as nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) which regulates the transcription of many genes involved in redox balance, detoxification, metabolism and inflammation. Activation of Nrf2 results in the synthesis of heme oxygenase-1 (HO-1) leading to the formation of a number of bioactive metabolites, mainly CO, biliverdin and bilirubin. Ample evidence supports the notion that Nrf2 and HO-1 can confer protection against oxidative stress and inflammatory and immune responses in joint tissues. As a consequence, this pathway may control the activation and metabolism of articular cells to play a regulatory role in joint destruction thus offering new opportunities for better treatments. Further studies are necessary to identify improved strategies to regulate Nrf2 and HO-1 activation in order to enable the development of drugs with therapeutic applications in joint diseases. es_ES
dc.description.sponsorship This work has been funded by grant SAF2017-85806-R (MINECO, FEDER, Spain). es_ES
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof Free Radical Biology and Medicine es_ES
dc.rights Reserva de todos los derechos es_ES
dc.title Relevance of Nrf2 and heme oxygenase-1 in articular diseases es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.freeradbiomed.2019.12.007 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-85806-R/ES/MECANISMOS REGULADORES DE LA INFLAMACION Y SU RESOLUCION EN ENFERMEDADES CRONICAS ARTICULARES Y DE LA PIEL/ es_ES
dc.rights.accessRights Cerrado es_ES
dc.description.bibliographicCitation Alcaraz Tormo, MJ.; Ferrándiz Manglano, ML. (2020). Relevance of Nrf2 and heme oxygenase-1 in articular diseases. Free Radical Biology and Medicine. 157:83-93. https://doi.org/10.1016/j.freeradbiomed.2019.12.007 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1016/j.freeradbiomed.2019.12.007 es_ES
dc.description.upvformatpinicio 83 es_ES
dc.description.upvformatpfin 93 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 157 es_ES
dc.identifier.pmid 31830562 es_ES
dc.relation.pasarela S\436556 es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
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