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An integrated microcircuit model of attentional processing in the neocortex

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An integrated microcircuit model of attentional processing in the neocortex

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dc.contributor.author Ardid-Ramírez, Joan Salvador es_ES
dc.contributor.author Wang, Xiao-Jing es_ES
dc.contributor.author Compte, A. es_ES
dc.date.accessioned 2021-05-29T03:33:41Z
dc.date.available 2021-05-29T03:33:41Z
dc.date.issued 2007-08-08 es_ES
dc.identifier.issn 0270-6474 es_ES
dc.identifier.uri http://hdl.handle.net/10251/166965
dc.description.abstract [EN] Selective attention is a fundamental cognitive function that uses top-down signals to orient and prioritize information processing in the brain. Single-cell recordings from behaving monkeys have revealed a number of attention-induced effects on sensory neurons, and have given rise to contrasting viewpoints about the neural underpinning of attentive processing. Moreover, there is evidence that attentional signals originate from the prefrontoparietal working memory network, but precisely how a source area of attention interacts with a sensory system remains unclear. To address these questions, we investigated a biophysically based network model of spiking neurons composed of a reciprocally connected loop of two (sensory and working memory) networks. We found that a wide variety of physiological phenomena induced by selective attention arise naturally in such a system. In particular, our work demonstrates a neural circuit that instantiates the "feature-similarity gain modulation principle," according to which the attentional gain effect on sensory neuronal responses is a graded function of the difference between the attended feature and the preferred feature of the neuron, independent of the stimulus. Furthermore, our model identifies key circuit mechanisms that underlie feature-similarity gain modulation, multiplicative scaling of tuning curve, and biased competition, and provide specific testable predictions. These results offer a synthetic account of the diverse attentional effects, suggesting a canonical neural circuit for feature-based attentional processing in the cortex. es_ES
dc.description.sponsorship This work was supported by the Volkswagen Foundation, the Spanish Ministry of Education and Science (S.A., A.C.), the European Regional Development Fund (A.C.), and the Swartz Foundation (X.-J.W.). A.C. was supported by a Ramón y Cajal Research Fellowship of the Spanish Ministry of Education and Science and by the Researcher Stabilization Program of the Health Department of the Generalitat de Catalunya. We thank S. Treue for helpful discussions on feature-based attention, and E. Marder, J. Mazer, and A. Renart for helpful comments on a previous version of this manuscript. es_ES
dc.language Inglés es_ES
dc.publisher Society for Neuroscience es_ES
dc.relation.ispartof Journal of Neuroscience es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Feature-Based attention es_ES
dc.subject Cortical circuits es_ES
dc.subject Working memory es_ES
dc.subject Sensory systems es_ES
dc.subject Computational model es_ES
dc.subject Top-Down es_ES
dc.subject Control es_ES
dc.subject.classification FISICA APLICADA es_ES
dc.title An integrated microcircuit model of attentional processing in the neocortex es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1523/JNEUROSCI.1145-07.2007 es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Investigación para la Gestión Integral de Zonas Costeras - Institut d'Investigació per a la Gestió Integral de Zones Costaneres es_ES
dc.description.bibliographicCitation Ardid-Ramírez, JS.; Wang, X.; Compte, A. (2007). An integrated microcircuit model of attentional processing in the neocortex. Journal of Neuroscience. 27(32):8486-8495. https://doi.org/10.1523/JNEUROSCI.1145-07.2007 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1523/JNEUROSCI.1145-07.2007 es_ES
dc.description.upvformatpinicio 8486 es_ES
dc.description.upvformatpfin 8495 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 27 es_ES
dc.description.issue 32 es_ES
dc.identifier.pmid 17687026 es_ES
dc.identifier.pmcid PMC6672949 es_ES
dc.relation.pasarela S\435003 es_ES
dc.contributor.funder Swartz Foundation es_ES
dc.contributor.funder Volkswagen Foundation es_ES
dc.contributor.funder Generalitat de Catalunya es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Ministerio de Educación y Ciencia es_ES


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