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Toxicological implications of amplifying the antibacterial activity of gallic acid by immobilisation on silica particles: a study on C. elegans

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Toxicological implications of amplifying the antibacterial activity of gallic acid by immobilisation on silica particles: a study on C. elegans

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dc.contributor.author Verdú, Samuel es_ES
dc.contributor.author Ruiz Rico, María es_ES
dc.contributor.author Pérez Jiménez, Alberto José es_ES
dc.contributor.author Barat Baviera, José Manuel es_ES
dc.contributor.author Talens Oliag, Pau es_ES
dc.contributor.author Grau Meló, Raúl es_ES
dc.date.accessioned 2021-06-12T03:33:08Z
dc.date.available 2021-06-12T03:33:08Z
dc.date.issued 2020-11 es_ES
dc.identifier.issn 1382-6689 es_ES
dc.identifier.uri http://hdl.handle.net/10251/167847
dc.description.abstract [EN] Immobilisation of natural compounds on solid supports to amplify antimicrobial properties has reported successful results, but modifications to physico-chemical properties can also imply modifications from a toxicological viewpoint. This work aimed to study the immobilising process of gallic acid in the antibacterial activity of L. innocua and its toxicological properties in vivo using Caenorhabditis elegans. The experiment was based on obtaining the minimum bactericidal concentration for free and immobilised gallic acid by comparing lethality, locomotion behaviour, chemotaxis and thermal stress resistance on C.elegans at those concentrations. The results showed a lowering minimum bactericidal concentration and modifications to nematode responses. Increased lethality and velocity of movements was observed. Immobilisation increased the repellent effect of gallic acid with a negative chemotaxis index. Thermal stress resistance was also affected, with higher mortality for immobilised gallic acid compared to bare particles and free gallic acid. Thus despite evidencing a generalised increase in the toxicity of gallic acid in vivo, lowering the minimum bactericidal concentration allowed a bacterial reduction of 99 % with less than one third of mortality for the nematodes exposed to free gallic acid. es_ES
dc.description.sponsorship The authors gratefully acknowledge financial support from the University Polytechnic of Valencia by programme "Ayudas para la Contratacion de Doctores para el Acceso al Sistema Espanol de Ciencia, Tecnologia e Innovacion, en Estructuras de Investigacion de la UPV (PAID-10-17)" and the Ministerio de Ciencia, Innovacion y Universidades, the Agencia Estatal de Investigacion and FEDER-EU (Project RTI2018-101599-B-C21). es_ES
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof Environmental Toxicology and Pharmacology es_ES
dc.rights Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) es_ES
dc.subject Gallic acid es_ES
dc.subject Immobilisation es_ES
dc.subject Silica microparticles es_ES
dc.subject LC50 es_ES
dc.subject Behaviour es_ES
dc.subject Thermal resistance es_ES
dc.subject.classification ARQUITECTURA Y TECNOLOGIA DE COMPUTADORES es_ES
dc.subject.classification TECNOLOGIA DE ALIMENTOS es_ES
dc.title Toxicological implications of amplifying the antibacterial activity of gallic acid by immobilisation on silica particles: a study on C. elegans es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.etap.2020.103492 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-101599-B-C21/ES/DESARROLLO Y APLICACION DE SISTEMAS ANTIMICROBIANOS PARA LA INDUSTRIA ALIMENTARIA BASADOS EN SUPERFICIES FUNCIONALIZADAS Y SISTEMAS DE LIBERACION CONTROLADA/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/UPV//PAID-10-17/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Informática de Sistemas y Computadores - Departament d'Informàtica de Sistemes i Computadors es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Tecnología de Alimentos - Departament de Tecnologia d'Aliments es_ES
dc.description.bibliographicCitation Verdú, S.; Ruiz Rico, M.; Pérez Jiménez, AJ.; Barat Baviera, JM.; Talens Oliag, P.; Grau Meló, R. (2020). Toxicological implications of amplifying the antibacterial activity of gallic acid by immobilisation on silica particles: a study on C. elegans. Environmental Toxicology and Pharmacology. 80:1-8. https://doi.org/10.1016/j.etap.2020.103492 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1016/j.etap.2020.103492 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 8 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 80 es_ES
dc.identifier.pmid 32941999 es_ES
dc.relation.pasarela S\417949 es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Universitat Politècnica de València es_ES
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