- -

Co-loading of finasteride and baicalin in phospholipid vesicles tailored for the treatment of hair disorders

RiuNet: Repositorio Institucional de la Universidad Politécnica de Valencia

Compartir/Enviar a

Citas

Estadísticas

  • Estadisticas de Uso

Co-loading of finasteride and baicalin in phospholipid vesicles tailored for the treatment of hair disorders

Mostrar el registro sencillo del ítem

Ficheros en el ítem

[Cerrado]
Nombre: Mr-Palomo;Nácher; ...
Tamaño: 2.903Mb
Formato: PDF
Descripción: Versión editorial
Solicitar una copia al autor
dc.contributor.author Mir-Palomo, Silvia es_ES
dc.contributor.author Nácher Alonso, María Amparo es_ES
dc.contributor.author Vila-Busó, M. A. Ofelia es_ES
dc.contributor.author Caddeo, Carla es_ES
dc.contributor.author Manca, Maria Letizia es_ES
dc.contributor.author Ruiz Saurí, Amparo es_ES
dc.contributor.author Escribano-Ferrer, Elvira es_ES
dc.contributor.author Manconi, Maria es_ES
dc.contributor.author Díez-Sales, Octavio es_ES
dc.date.accessioned 2021-06-12T03:33:24Z
dc.date.available 2021-06-12T03:33:24Z
dc.date.issued 2020-08-14 es_ES
dc.identifier.issn 2040-3364 es_ES
dc.identifier.uri http://hdl.handle.net/10251/167855
dc.description.abstract [EN] Hair loss affects a large number of people worldwide and it has a negative impact on the quality of life. Despite the availability of different drugs for the treatment of hair disorders, therapeutic options are still limited and scarcely effective. An innovative strategy to improve the efficacy of alopecia treatment is presented in this work. Finasteride, the only oral synthetic drug approved by Unites States Federal Drug Administration, was loaded in phospholipid vesicles. In addition, baicalin was co-loaded as an adjuvant. Their effect on hair growth was evaluatedin vitroandin vivo. Liposomes, hyalurosomes, glycerosomes and glycerol-hyalurosomes were manufactured by using a simple method that avoids the use of organic solvents. All the vesicles were small in size (similar to 100 nm), homogeneously dispersed (polydispersity index <= 0.27) and negatively charged (similar to-16 mV). The formulations were able to stimulate the proliferation of human dermal papilla cells, which are widely used in hair physiology studies. The analysis of hair growth and hair follicles of C57BL/6 mice, treated with the formulations for 21 days, underlined the ability of the vesicles to improve hair growth by the simultaneous follicular delivery of finasteride and baicalin. Therefore, the developed nanosystems can represent a promising tool to ensure the efficacy of the local treatment of hair loss. es_ES
dc.language Inglés es_ES
dc.publisher The Royal Society of Chemistry es_ES
dc.relation.ispartof Nanoscale es_ES
dc.rights Reserva de todos los derechos es_ES
dc.title Co-loading of finasteride and baicalin in phospholipid vesicles tailored for the treatment of hair disorders es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1039/d0nr03357j es_ES
dc.rights.accessRights Cerrado es_ES
dc.description.bibliographicCitation Mir-Palomo, S.; Nácher Alonso, MA.; Vila-Busó, MAO.; Caddeo, C.; Manca, ML.; Ruiz Saurí, A.; Escribano-Ferrer, E.... (2020). Co-loading of finasteride and baicalin in phospholipid vesicles tailored for the treatment of hair disorders. Nanoscale. 12(30):16143-16152. https://doi.org/10.1039/d0nr03357j es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1039/d0nr03357j es_ES
dc.description.upvformatpinicio 16143 es_ES
dc.description.upvformatpfin 16152 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 12 es_ES
dc.description.issue 30 es_ES
dc.identifier.pmid 32700723 es_ES
dc.relation.pasarela S\436557 es_ES
dc.description.references Zhang, Y., Han, L., Chen, S.-S., Guan, J., Qu, F.-Z., & Zhao, Y.-Q. (2016). Hair growth promoting activity of cedrol isolated from the leaves of Platycladus orientalis. Biomedicine & Pharmacotherapy, 83, 641-647. doi:10.1016/j.biopha.2016.07.022 es_ES
dc.description.references Santos, Z., Avci, P., & Hamblin, M. R. (2015). Drug discovery for alopecia: gone today, hair tomorrow. Expert Opinion on Drug Discovery, 10(3), 269-292. doi:10.1517/17460441.2015.1009892 es_ES
dc.description.references Dong, L., Hao, H., Xia, L., Liu, J., Ti, D., Tong, C., … Han, W. (2014). Treatment of MSCs with Wnt1a-conditioned medium activates DP cells and promotes hair follicle regrowth. Scientific Reports, 4(1). doi:10.1038/srep05432 es_ES
dc.description.references S. Müller-Röver , K.Foitzik and R.Paus , B. H.-J. of I. and undefined , Elsevier , 2001 es_ES
dc.description.references Ocampo-Garza, J., Griggs, J., & Tosti, A. (2019). New drugs under investigation for the treatment of alopecias. Expert Opinion on Investigational Drugs, 28(3), 275-284. doi:10.1080/13543784.2019.1568989 es_ES
dc.description.references Y. Feng , L.Ma , X.Li and W.Ding , X. C.-B. & Pharmacotherapy and undefined , Elsevier , 2017 es_ES
dc.description.references M. Górecki , A.Dziedzic and R.Luboradzki , A. O.-Steroids and undefined , Elsevier , 2017 es_ES
dc.description.references RATTANACHITTHAWAT, N., PINKHIEN, T., OPANASOPIT, P., NGAWHIRUNPAT, T., & CHANVORACHOTE, P. (2019). Finasteride Enhances Stem Cell Signals of Human Dermal Papilla Cells. In Vivo, 33(4), 1209-1220. doi:10.21873/invivo.11592 es_ES
dc.description.references Khan, M. Z. U., Khan, S. A., Ubaid, M., Shah, A., Kousar, R., & Murtaza, G. (2018). Finasteride Topical Delivery Systems for Androgenetic Alopecia. Current Drug Delivery, 15(8), 1100-1111. doi:10.2174/1567201815666180124112905 es_ES
dc.description.references Hosking, A.-M., Juhasz, M., & Atanaskova Mesinkovska, N. (2018). Complementary and Alternative Treatments for Alopecia: A Comprehensive Review. Skin Appendage Disorders, 5(2), 72-89. doi:10.1159/000492035 es_ES
dc.description.references Jakab, G., Bogdán, D., Mazák, K., Deme, R., Mucsi, Z., Mándity, I. M., … Antal, I. (2019). Physicochemical Profiling of Baicalin Along with the Development and Characterization of Cyclodextrin Inclusion Complexes. AAPS PharmSciTech, 20(8). doi:10.1208/s12249-019-1525-6 es_ES
dc.description.references Shin, S. H., Bak, S.-S., Kim, M. K., Sung, Y. K., & Kim, J. C. (2014). Baicalin, a flavonoid, affects the activity of human dermal papilla cells and promotes anagen induction in mice. Naunyn-Schmiedeberg’s Archives of Pharmacology, 388(5), 583-586. doi:10.1007/s00210-014-1075-0 es_ES
dc.description.references Kim, A.-R., Kim, S.-N., Jung, I.-K., Kim, H.-H., Park, Y.-H., & Park, W.-S. (2014). The Inhibitory Effect of Scutellaria baicalensis Extract and Its Active Compound, Baicalin, on the Translocation of the Androgen Receptor with Implications for Preventing Androgenetic Alopecia. Planta Medica, 80(02/03), 153-158. doi:10.1055/s-0033-1360300 es_ES
dc.description.references Y. Qian , Y.Chen and L.Wang , J. T.-A. cirurgica brasileira and undefined , SciELO Bras , 2018 es_ES
dc.description.references Gao, C., Zhou, Y., Li, H., Cong, X., Jiang, Z., Wang, X., … Tian, W. (2017). Antitumor effects of baicalin on ovarian cancer cells through induction of cell apoptosis and inhibition of cell migration in vitro. Molecular Medicine Reports, 16(6), 8729-8734. doi:10.3892/mmr.2017.7757 es_ES
dc.description.references Mir-Palomo, S., Nácher, A., Díez-Sales, O., Ofelia Vila Busó, M. A., Caddeo, C., Manca, M. L., … Saurí, A. R. (2016). Inhibition of skin inflammation by baicalin ultradeformable vesicles. International Journal of Pharmaceutics, 511(1), 23-29. doi:10.1016/j.ijpharm.2016.06.136 es_ES
dc.description.references Wang, J., Jiao, H., Meng, J., Qiao, M., Du, H., He, M., … Wu, Y. (2019). Baicalin Inhibits Biofilm Formation and the Quorum-Sensing System by Regulating the MsrA Drug Efflux Pump in Staphylococcus saprophyticus. Frontiers in Microbiology, 10. doi:10.3389/fmicb.2019.02800 es_ES
dc.description.references T. Ahmed , M. K.-E. J. of P. Sciences and undefined , Elsevier , 2016 es_ES
dc.description.references R. El-Gogary and S.Gaber , M. N.-S. reports and undefined , nature.com , 2019 es_ES
dc.description.references Benson, H. A. E., Grice, J. E., Mohammed, Y., Namjoshi, S., & Roberts, M. S. (2019). Topical and Transdermal Drug Delivery: From Simple Potions to Smart Technologies. Current Drug Delivery, 16(5), 444-460. doi:10.2174/1567201816666190201143457 es_ES
dc.description.references Fang, C.-L., Aljuffali, I. A., Li, Y.-C., & Fang, J.-Y. (2014). Delivery and targeting of nanoparticles into hair follicles. Therapeutic Delivery, 5(9), 991-1006. doi:10.4155/tde.14.61 es_ES
dc.description.references A. Zeb , O.Qureshi and H.Kim , J. C.-I. journal of and undefined , ncbi.nlm.nih.gov , 2016 es_ES
dc.description.references Manca, M. L., Usach, I., Peris, J. E., Ibba, A., Orrù, G., Valenti, D., … Manconi, M. (2019). Optimization of Innovative Three-Dimensionally-Structured Hybrid Vesicles to Improve the Cutaneous Delivery of Clotrimazole for the Treatment of Topical Candidiasis. Pharmaceutics, 11(6), 263. doi:10.3390/pharmaceutics11060263 es_ES
dc.description.references Ascenso, A., Batista, C., Cardoso, P., Mendes, T., Praça, F., Bentley, V., … Simões, S. (2015). Development, characterization, and skin delivery studies of related ultradeformable vesicles: transfersomes, ethosomes, and transethosomes. International Journal of Nanomedicine, 5837. doi:10.2147/ijn.s86186 es_ES
dc.description.references Castangia, I., Manca, M. L., Caddeo, C., Maxia, A., Murgia, S., Pons, R., … Manconi, M. (2015). Faceted phospholipid vesicles tailored for the delivery of Santolina insularis essential oil to the skin. Colloids and Surfaces B: Biointerfaces, 132, 185-193. doi:10.1016/j.colsurfb.2015.05.025 es_ES
dc.description.references Manconi, M., Marongiu, F., Manca, M. L., Caddeo, C., Sarais, G., Cencetti, C., … Fadda, A. M. (2017). Nanoincorporation of bioactive compounds from red grape pomaces: In vitro and ex vivo evaluation of antioxidant activity. International Journal of Pharmaceutics, 523(1), 159-166. doi:10.1016/j.ijpharm.2017.03.037 es_ES
dc.description.references Manca, M. L., Cencetti, C., Matricardi, P., Castangia, I., Zaru, M., Sales, O. D., … Manconi, M. (2016). Glycerosomes: Use of hydrogenated soy phosphatidylcholine mixture and its effect on vesicle features and diclofenac skin penetration. International Journal of Pharmaceutics, 511(1), 198-204. doi:10.1016/j.ijpharm.2016.07.009 es_ES
dc.description.references Bavarsad, N., Akhgari, A., Seifmanesh, S., Salimi, A., & Rezaie, A. (2016). Statistical optimization of tretinoin-loaded penetration-enhancer vesicles (PEV) for topical delivery. DARU Journal of Pharmaceutical Sciences, 24(1). doi:10.1186/s40199-016-0142-0 es_ES
dc.description.references Manca, M. L., Castangia, I., Zaru, M., Nácher, A., Valenti, D., Fernàndez-Busquets, X., … Manconi, M. (2015). Development of curcumin loaded sodium hyaluronate immobilized vesicles (hyalurosomes) and their potential on skin inflammation and wound restoring. Biomaterials, 71, 100-109. doi:10.1016/j.biomaterials.2015.08.034 es_ES
dc.description.references Castangia, I., Caddeo, C., Manca, M. L., Casu, L., Latorre, A. C., Díez-Sales, O., … Manconi, M. (2015). Delivery of liquorice extract by liposomes and hyalurosomes to protect the skin against oxidative stress injuries. Carbohydrate Polymers, 134, 657-663. doi:10.1016/j.carbpol.2015.08.037 es_ES
dc.description.references V. Truong , M.Bak , C.Lee and M.Jun , W. J.- Molecules and undefined , mdpi.com , 2017 es_ES
dc.description.references Manconi, M., Aparicio, J., Vila, A. ., Pendás, J., Figueruelo, J., & Molina, F. (2003). Viscoelastic properties of concentrated dispersions in water of soy lecithin. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 222(1-3), 141-145. doi:10.1016/s0927-7757(03)00249-8 es_ES
dc.description.references Catalan-Latorre, A., Ravaghi, M., Manca, M. L., Caddeo, C., Marongiu, F., Ennas, G., … Manconi, M. (2016). Freeze-dried eudragit-hyaluronan multicompartment liposomes to improve the intestinal bioavailability of curcumin. European Journal of Pharmaceutics and Biopharmaceutics, 107, 49-55. doi:10.1016/j.ejpb.2016.06.016 es_ES
dc.description.references Abd, E., Roberts, M. S., & Grice, J. E. (2015). A Comparison of the Penetration and Permeation of Caffeine into and through Human Epidermis after Application in Various Vesicle Formulations. Skin Pharmacology and Physiology, 29(1), 24-30. doi:10.1159/000441040 es_ES
dc.description.references Sennett, R., & Rendl, M. (2012). Mesenchymal–epithelial interactions during hair follicle morphogenesis and cycling. Seminars in Cell & Developmental Biology, 23(8), 917-927. doi:10.1016/j.semcdb.2012.08.011 es_ES
dc.description.references S. Arias-Santiago , A.Buendía-Eisman , M. T.Gutiérrez-Salmerón and S.Serrano-Ortega , in Handbook of Hair in Health and Disease , MDText.com, Inc. , 2012 , pp. 99–116 es_ES
dc.description.references Manca, M. L., Manconi, M., Zaru, M., Valenti, D., Peris, J. E., Matricardi, P., … Fadda, A. M. (2017). Glycerosomes: Investigation of role of 1,2-dimyristoyl-sn-glycero-3-phosphatidycholine (DMPC) on the assembling and skin delivery performances. International Journal of Pharmaceutics, 532(1), 401-407. doi:10.1016/j.ijpharm.2017.09.026 es_ES
dc.description.references Shapiro, J., & Kaufman, K. D. (2003). Use of Finasteride in the Treatment of Men With Androgenetic Alopecia (Male Pattern Hair Loss). Journal of Investigative Dermatology Symposium Proceedings, 8(1), 20-23. doi:10.1046/j.1523-1747.2003.12167.x es_ES
dc.description.references Price, V. H., Roberts, J. L., Hordinsky, M., Olsen, E. A., Savin, R., Bergfeld, W., … Waldstreicher, J. (2000). Lack of efficacy of finasteride in postmenopausal women with androgenetic alopecia. Journal of the American Academy of Dermatology, 43(5), 768-776. doi:10.1067/mjd.2000.107953 es_ES
dc.description.references Oliveira-Soares, R., e Silva, Jm., Correia, Mp., & André, M. (2013). Finasteride 5 mg/day treatment of patterned hair loss in normo-androgenetic postmenopausal women. International Journal of Trichology, 5(1), 22. doi:10.4103/0974-7753.114709 es_ES
dc.description.references Tabbakhian, M., Tavakoli, N., Jaafari, M. R., & Daneshamouz, S. (2006). Enhancement of follicular delivery of finasteride by liposomes and niosomes. International Journal of Pharmaceutics, 323(1-2), 1-10. doi:10.1016/j.ijpharm.2006.05.041 es_ES
dc.description.references Manconi, M., Mura, S., Sinico, C., Fadda, A. M., Vila, A. O., & Molina, F. (2009). Development and characterization of liposomes containing glycols as carriers for diclofenac. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 342(1-3), 53-58. doi:10.1016/j.colsurfa.2009.04.006 es_ES
dc.description.references Rao, Y., Zheng, F., Zhang, X., Gao, J., & Liang, W. (2008). In Vitro Percutaneous Permeation and Skin Accumulation of Finasteride Using Vesicular Ethosomal Carriers. AAPS PharmSciTech, 9(3), 860-865. doi:10.1208/s12249-008-9124-y es_ES
dc.description.references Rao, Y., Zheng, F., Liang, X., Wang, H., Zhang, J., & Lu, X. (2013). Penetration profile and human cadaver skin distribution of finasteride from vesicular nanocarriers. Drug Delivery, 22(8), 1003-1009. doi:10.3109/10717544.2013.839128 es_ES
dc.description.references Fluhr, J. W., Darlenski, R., & Surber, C. (2008). Glycerol and the skin: holistic approach to its origin and functions. British Journal of Dermatology, 159(1), 23-34. doi:10.1111/j.1365-2133.2008.08643.x es_ES
dc.description.references Brown, M., & Jones, S. (2005). Hyaluronic acid: a unique topical vehicle for the localized delivery of drugs to the skin. Journal of the European Academy of Dermatology and Venereology, 19(3), 308-318. doi:10.1111/j.1468-3083.2004.01180.x es_ES


Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem