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First-Episode Psychotic Patients Showed Longitudinal Brain Changes Using fMRI With an Emotional Auditory Paradigm

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First-Episode Psychotic Patients Showed Longitudinal Brain Changes Using fMRI With an Emotional Auditory Paradigm

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dc.contributor.author González-Vivas, Carlos es_ES
dc.contributor.author García-Martí, Gracián es_ES
dc.contributor.author Soldevila-Matías, Pau es_ES
dc.contributor.author Sanz-Requena, Roberto es_ES
dc.contributor.author Aguilar, Eduardo J. es_ES
dc.contributor.author Castro-Bleda, Maria Jose es_ES
dc.contributor.author Martí-Bonmatí, Luis es_ES
dc.contributor.author Sanjuan, Julio es_ES
dc.date.accessioned 2021-06-15T03:31:30Z
dc.date.available 2021-06-15T03:31:30Z
dc.date.issued 2020-12-11 es_ES
dc.identifier.uri http://hdl.handle.net/10251/167981
dc.description.abstract [EN] Most previous longitudinal studies of functional magnetic resonance imaging (fMRI) in first-episode psychosis (FEP) using cognitive paradigm task found an increased activation after antipsychotic medications. We designed an emotional auditory paradigm to explore brain activation during emotional and nonemotional word processing. This study aimed to analyze if longitudinal changes in brain fMRI BOLD activation is present in patients vs. healthy controls. A group of FEP patients (n = 34) received clinical assessment and had a fMRI scan at baseline and follow-up (average, 25-month interval). During the fMRI scan, both emotional and nonemotional words were presented as a block design. Results were compared with a pair of healthy control group (n = 13). Patients showed a decreased activation at follow-up fMRI in amygdala (F = 4.69; p = 0.04) and hippocampus (F = 5.03; p = 0.03) compared with controls. Middle frontal gyrus was the only area that showed a substantial increased activation in patients (F = 4.53; p = 0.04). A great heterogeneity in individual activation patterns was also found. These results support the relevance of the type of paradigm in neuroimaging for psychosis. This is, as far as we know, the first longitudinal study with an emotional auditory paradigm in FEP. Our results suggested that the amygdala and hippocampus play a key role in psychotic disease. More studies are needed to understand the heterogeneity of response at individual level. es_ES
dc.description.sponsorship This study was supported by grants from the Generalitat Valenciana (PROMETEO/2016/082, PROMETEO/2020/024), CIBERSAM, and Carlos III Health Institute (PI13/00447; PI17/00402) co-funded by The European Union through FEDER funds. es_ES
dc.language Inglés es_ES
dc.publisher Frontiers Media S.A. es_ES
dc.relation.ispartof Frontiers in Psychiatry es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject First episode psychosis (FEP) es_ES
dc.subject FMRI-functional magnetic resonance imaging es_ES
dc.subject Longitudinal es_ES
dc.subject Emotional design model es_ES
dc.subject Paradigm es_ES
dc.subject Follow up es_ES
dc.subject.classification LENGUAJES Y SISTEMAS INFORMATICOS es_ES
dc.title First-Episode Psychotic Patients Showed Longitudinal Brain Changes Using fMRI With an Emotional Auditory Paradigm es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.3389/fpsyt.2020.593042 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEO%2F2016%2F082/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//PI13%2F00447/ES/MARCADORES GENETICOS Y DE NEUROIMAGEN PARA LOS TRASTORNOS DEL LENGUAJE EN LA PSICOSIS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/ISCIII//PI17%2F00402/ES/Resonancia magnética funcional y expresión génica como predictores en primeros episodios psicóticos/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEO%2F2020%2F024/ES/Investigación de marcadores biológicos y nuevas estrategias terapéuticas en la psicosis/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Sistemas Informáticos y Computación - Departament de Sistemes Informàtics i Computació es_ES
dc.description.bibliographicCitation González-Vivas, C.; García-Martí, G.; Soldevila-Matías, P.; Sanz-Requena, R.; Aguilar, EJ.; Castro-Bleda, MJ.; Martí-Bonmatí, L.... (2020). First-Episode Psychotic Patients Showed Longitudinal Brain Changes Using fMRI With an Emotional Auditory Paradigm. Frontiers in Psychiatry. 11:1-9. https://doi.org/10.3389/fpsyt.2020.593042 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.3389/fpsyt.2020.593042 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 9 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 11 es_ES
dc.identifier.eissn 1664-0640 es_ES
dc.identifier.pmid 33424663 es_ES
dc.identifier.pmcid PMC7794005 es_ES
dc.relation.pasarela S\427386 es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Instituto de Salud Carlos III es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
dc.contributor.funder Centro de Investigación Biomédica en Red de Salud Mental es_ES
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