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Mangiferin glycethosomes as a new potential adjuvant for the treatment of psoriasis

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Mangiferin glycethosomes as a new potential adjuvant for the treatment of psoriasis

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dc.contributor.author Pleguezuelos-Villa, María es_ES
dc.contributor.author Díez-Sales, Octavio es_ES
dc.contributor.author Manca, M.L. es_ES
dc.contributor.author Manconi, Maria es_ES
dc.contributor.author Saurí, A.R. es_ES
dc.contributor.author Escribano-Ferrer, E. es_ES
dc.contributor.author NÁCHER ALONSO, Mª AMPARO es_ES
dc.date.accessioned 2021-06-23T03:30:37Z
dc.date.available 2021-06-23T03:30:37Z
dc.date.issued 2020-01-05 es_ES
dc.identifier.issn 0378-5173 es_ES
dc.identifier.uri http://hdl.handle.net/10251/168335
dc.description.abstract [EN] Mangiferin, a natural compound isolated from Mangifera indica L, was incorporated in glycerosomes, ethosomes and alternatively in glycerol-ethanol phospholipid vesicles (glycethosomes). Actually, only glycethosomes were able to stably incorporate the mangiferin that was loaded at increasing concentrations (2, 4, 6, 8 mg/mL). The morphology, size distribution, rheological properties, surface charge and entrapment efficiency of prepared vesicles were deeply measured. All vesicles were mainly spherical, oligolamellar, small in size (similar to 145 nm) and negatively charged (similar to-40 mV), as confirmed by cryo-TEM observation and dynamic laser light scattering measurements. The higher concentration of mangiferin (8 mg/mL) allowed an increase of vesicle mean diameter up to similar to 288 nm. The entrapment efficiency was inversely proportional to the amount of loaded mangiferin. In vitro studies performed by using human abdominal skin, underlined that, the dose-dependent ability of vesicles to promote mangiferin retention in epidermis. In addition, glycethosomes were highly biocompatible and showed a strong ability to protect in vitro the fibroblasts against damages induced by hydrogen peroxide. In vivo results underlined the superior ability of mangiferin loaded glycethosomes respect to the mangiferin dispersion to promote the heal of the wound induced by TPA, confirming their potential application for the treatment of psoriasis or other skin disorders. es_ES
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof International Journal of Pharmaceutics es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Mangiferin es_ES
dc.subject Phospholipid vesicles es_ES
dc.subject Glycethosomes es_ES
dc.subject Antioxidant es_ES
dc.subject Skin permeation es_ES
dc.subject Psoriasis es_ES
dc.title Mangiferin glycethosomes as a new potential adjuvant for the treatment of psoriasis es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.ijpharm.2019.118844 es_ES
dc.rights.accessRights Cerrado es_ES
dc.description.bibliographicCitation Pleguezuelos-Villa, M.; Díez-Sales, O.; Manca, M.; Manconi, M.; Saurí, A.; Escribano-Ferrer, E.; Nácher Alonso, MA. (2020). Mangiferin glycethosomes as a new potential adjuvant for the treatment of psoriasis. International Journal of Pharmaceutics. 573:1-8. https://doi.org/10.1016/j.ijpharm.2019.118844 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1016/j.ijpharm.2019.118844 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 8 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 573 es_ES
dc.identifier.pmid 31751638 es_ES
dc.relation.pasarela S\436558 es_ES
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