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Prefrontal oscillations modulate the propagation of neuronal activity required for working memory

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Prefrontal oscillations modulate the propagation of neuronal activity required for working memory

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dc.contributor.author Sherfey, Jason es_ES
dc.contributor.author Ardid-Ramírez, Joan Salvador es_ES
dc.contributor.author Miller, Earl K. es_ES
dc.contributor.author Hasselmo, Michael E. es_ES
dc.contributor.author Kopell, Nancy J. es_ES
dc.date.accessioned 2021-07-30T03:31:11Z
dc.date.available 2021-07-30T03:31:11Z
dc.date.issued 2020-09 es_ES
dc.identifier.issn 1074-7427 es_ES
dc.identifier.uri http://hdl.handle.net/10251/170960
dc.description.abstract [EN] Cognition involves using attended information, maintained in working memory (WM), to guide action. During a cognitive task, a correct response requires flexible, selective gating so that only the appropriate information flows from WM to downstream effectors that carry out the response. In this work, we used biophysically-detailed modeling to explore the hypothesis that network oscillations in prefrontal cortex (PFC), leveraging local inhibition, can independently gate responses to items in WM. The key role of local inhibition was to control the period between spike bursts in the outputs, and to produce an oscillatory response no matter whether the WM item was maintained in an asynchronous or oscillatory state. We found that the WM item that induced an oscillatory population response in the PFC output layer with the shortest period between spike bursts was most reliably propagated. The network resonant frequency (i.e., the input frequency that produces the largest response) of the output layer can be flexibly tuned by varying the excitability of deep layer principal cells. Our model suggests that experimentally-observed modulation of PFC beta-frequency (15-30 Hz) and gamma -frequency (30-80 Hz) oscillations could leverage network resonance and local inhibition to govern the flexible routing of signals in service to cognitive processes like gating outputs from working memory and the selection of rule-based actions. Importantly, we show for the first time that nonspecific changes in deep layer excitability can tune the output gate's resonant frequency, enabling the specific selection of signals encoded by populations in asynchronous or fast oscillatory states. More generally, this represents a dynamic mechanism by which adjusting network excitability can govern the propagation of asynchronous and oscillatory signals throughout neocortex. es_ES
dc.description.sponsorship This work was supported by the U.S. Army Research Office under award number ARO W911NF-12-R-0012-02 to N. K., the U.S. Office of Naval Research under award number ONR MURI N00014-16-1-2832 to M. H. and E. M., the National Institute of Mental Health under award number NIMH R37MH087027 to E. M., and The MIT Picower Institute Faculty Innovation Fund to E. M. We would like to acknowledge Joachim Hass and Michelle McCarthy for early discussions of our modeling results, as well as Andre Bastos and Mikael Lundqvist for discussions relating our modeling work to their experiments. es_ES
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof Neurobiology of Learning and Memory es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Cognition es_ES
dc.subject Working memory es_ES
dc.subject Gating es_ES
dc.subject Beta rhythm es_ES
dc.subject Gamma rhythm es_ES
dc.subject Resonance es_ES
dc.subject.classification FISICA APLICADA es_ES
dc.title Prefrontal oscillations modulate the propagation of neuronal activity required for working memory es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.nlm.2020.107228 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/NIH//R37MH087027/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/ARO//W911NF-12-R-0012-02/US/Event-Driven Game Theory for Predicting Dynamical Systems/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/ONR//N00014-16-1-2832/US/ONR MURI: Neural circuits underlying symbolic processing in primate cortex and basal ganglia/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Investigación para la Gestión Integral de Zonas Costeras - Institut d'Investigació per a la Gestió Integral de Zones Costaneres es_ES
dc.description.bibliographicCitation Sherfey, J.; Ardid-Ramírez, JS.; Miller, EK.; Hasselmo, ME.; Kopell, NJ. (2020). Prefrontal oscillations modulate the propagation of neuronal activity required for working memory. Neurobiology of Learning and Memory. 173:1-13. https://doi.org/10.1016/j.nlm.2020.107228 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1016/j.nlm.2020.107228 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 13 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 173 es_ES
dc.identifier.pmid 32561459 es_ES
dc.identifier.pmcid PMC7429344 es_ES
dc.relation.pasarela S\434964 es_ES
dc.contributor.funder Office of Naval Research es_ES
dc.contributor.funder Army Research Office, EEUU es_ES
dc.contributor.funder National Institute of Mental Health, EEUU es_ES
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