- -

Influence of pre-polymerisation atmosphere on the properties of pre- and poly(glycerol sebacate)

RiuNet: Repositorio Institucional de la Universidad Politécnica de Valencia

Compartir/Enviar a

Citas

Estadísticas

  • Estadisticas de Uso

Influence of pre-polymerisation atmosphere on the properties of pre- and poly(glycerol sebacate)

Mostrar el registro sencillo del ítem

Ficheros en el ítem

Thumbnail
Nombre: Martin-CabezueloV ...
Tamaño: 854.4Kb
Formato: PDF
Descripción: Versión del Autor.
Abrir
[Cerrado]
Nombre: InfluencePrepolAt ...
Tamaño: 2.645Mb
Formato: PDF
Descripción: Versión editorial
Solicitar una copia al autor
dc.contributor.author Martín-Cabezuelo, Rubén es_ES
dc.contributor.author Vilariño, Guillermo es_ES
dc.contributor.author Vallés Lluch, Ana es_ES
dc.date.accessioned 2021-09-04T03:40:56Z
dc.date.available 2021-09-04T03:40:56Z
dc.date.issued 2021-02 es_ES
dc.identifier.issn 0928-4931 es_ES
dc.identifier.uri http://hdl.handle.net/10251/171418
dc.description.abstract [EN] Poly(glycerol sebacate) (PGS) is a versatile biodegradable biomaterial on account of its adjustable mechanical properties as an elastomeric polyester. Nevertheless, it has shown dissimilar results when synthesised by different research groups under equivalent synthesis conditions. This lack of reproducibility proves how crucial it is to understand the effect of the parameters involved on its manufacturing and characterize the polymer networks obtained. Several studies have been conducted in recent years to understand the role of temperature, time, and the molar ratio of its monomers, while the influence of the atmosphere applied during its pre-polymerisation remained unknown. The results obtained here allow for a better understanding about the effect of inert (Ar and N-2) and oxidative (oxygen, dry air, and humid air) atmospheres on the extent of the reaction. The molecular pattern of intermediate pre-polymers and the gelation time and morphology of their corresponding cured PGS networks were studied as well. Overall, inert atmospheres promote a rather linear growth of macromers, with scarce branches, resulting in loose elastomers with long chains mainly crosslinked. Conversely, oxygen in the latter atmospheres promotes branching through secondary hydroxyl groups, leading to less-crosslinked 'defective' networks. In this way, the pre-polymerisation atmosphere could be used advantageously to adjust the reactivity of secondary hydroxyls, in order to modulate branching in the elastomeric PGS networks obtained to suit the properties required in a particular application. es_ES
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof Materials Science and Engineering C es_ES
dc.rights Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) es_ES
dc.subject Poly(glycerol sebacate) es_ES
dc.subject Polymerisation atmosphere es_ES
dc.subject Glycerol es_ES
dc.subject Polycondensation es_ES
dc.subject Pre-polymerisation es_ES
dc.subject Curing es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title Influence of pre-polymerisation atmosphere on the properties of pre- and poly(glycerol sebacate) es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.msec.2020.111429 es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Centro de Biomateriales e Ingeniería Tisular - Centre de Biomaterials i Enginyeria Tissular es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.description.bibliographicCitation Martín-Cabezuelo, R.; Vilariño, G.; Vallés Lluch, A. (2021). Influence of pre-polymerisation atmosphere on the properties of pre- and poly(glycerol sebacate). Materials Science and Engineering C. 119:1-10. https://doi.org/10.1016/j.msec.2020.111429 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1016/j.msec.2020.111429 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 10 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 119 es_ES
dc.identifier.pmid 33321580 es_ES
dc.relation.pasarela S\413774 es_ES
dc.description.references Wang, Y., Kim, Y. M., & Langer, R. (2003). In vivo degradation characteristics of poly(glycerol sebacate). Journal of Biomedical Materials Research, 66A(1), 192-197. doi:10.1002/jbm.a.10534 es_ES
dc.description.references Rai, R., Tallawi, M., Grigore, A., & Boccaccini, A. R. (2012). Synthesis, properties and biomedical applications of poly(glycerol sebacate) (PGS): A review. Progress in Polymer Science, 37(8), 1051-1078. doi:10.1016/j.progpolymsci.2012.02.001 es_ES
dc.description.references Kharazi, A., Shirazaki, P., & Varshosaz, J. (2017). Electrospun Gelatin/poly(Glycerol Sebacate) Membrane with Controlled Release of Antibiotics for Wound Dressing. Advanced Biomedical Research, 6(1), 105. doi:10.4103/abr.abr_197_16 es_ES
dc.description.references Wang, Y., Ameer, G. A., Sheppard, B. J., & Langer, R. (2002). A tough biodegradable elastomer. Nature Biotechnology, 20(6), 602-606. doi:10.1038/nbt0602-602 es_ES
dc.description.references Ulery, B. D., Nair, L. S., & Laurencin, C. T. (2011). Biomedical applications of biodegradable polymers. Journal of Polymer Science Part B: Polymer Physics, 49(12), 832-864. doi:10.1002/polb.22259 es_ES
dc.description.references Stafiej, P., Küng, F., Thieme, D., Czugala, M., Kruse, F. E., Schubert, D. W., & Fuchsluger, T. A. (2017). Adhesion and metabolic activity of human corneal cells on PCL based nanofiber matrices. Materials Science and Engineering: C, 71, 764-770. doi:10.1016/j.msec.2016.10.058 es_ES
dc.description.references Salehi, S., Fathi, M., Javanmard, S., Barneh, F., & Moshayedi, M. (2015). Fabrication and characterization of biodegradable polymeric films as a corneal stroma substitute. Advanced Biomedical Research, 4(1), 9. doi:10.4103/2277-9175.148291 es_ES
dc.description.references Frydrych, M., Román, S., MacNeil, S., & Chen, B. (2015). Biomimetic poly(glycerol sebacate)/poly(l-lactic acid) blend scaffolds for adipose tissue engineering. Acta Biomaterialia, 18, 40-49. doi:10.1016/j.actbio.2015.03.004 es_ES
dc.description.references Hu, J., Kai, D., Ye, H., Tian, L., Ding, X., Ramakrishna, S., & Loh, X. J. (2017). Electrospinning of poly(glycerol sebacate)-based nanofibers for nerve tissue engineering. Materials Science and Engineering: C, 70, 1089-1094. doi:10.1016/j.msec.2016.03.035 es_ES
dc.description.references Rai, R., Tallawi, M., Barbani, N., Frati, C., Madeddu, D., Cavalli, S., … Boccaccini, A. R. (2013). Biomimetic poly(glycerol sebacate) (PGS) membranes for cardiac patch application. Materials Science and Engineering: C, 33(7), 3677-3687. doi:10.1016/j.msec.2013.04.058 es_ES
dc.description.references Masoumi, N., Johnson, K. L., Howell, M. C., & Engelmayr, G. C. (2013). Valvular interstitial cell seeded poly(glycerol sebacate) scaffolds: Toward a biomimetic in vitro model for heart valve tissue engineering. Acta Biomaterialia, 9(4), 5974-5988. doi:10.1016/j.actbio.2013.01.001 es_ES
dc.description.references Lin, D., Yang, K., Tang, W., Liu, Y., Yuan, Y., & Liu, C. (2015). A poly(glycerol sebacate)-coated mesoporous bioactive glass scaffold with adjustable mechanical strength, degradation rate, controlled-release and cell behavior for bone tissue engineering. Colloids and Surfaces B: Biointerfaces, 131, 1-11. doi:10.1016/j.colsurfb.2015.04.031 es_ES
dc.description.references Tevlek, A., Hosseinian, P., Ogutcu, C., Turk, M., & Aydin, H. M. (2017). Bi-layered constructs of poly(glycerol-sebacate)-β-tricalcium phosphate for bone-soft tissue interface applications. Materials Science and Engineering: C, 72, 316-324. doi:10.1016/j.msec.2016.11.082 es_ES
dc.description.references Masoudi Rad, M., Nouri Khorasani, S., Ghasemi-Mobarakeh, L., Prabhakaran, M. P., Foroughi, M. R., Kharaziha, M., … Ramakrishna, S. (2017). Fabrication and characterization of two-layered nanofibrous membrane for guided bone and tissue regeneration application. Materials Science and Engineering: C, 80, 75-87. doi:10.1016/j.msec.2017.05.125 es_ES
dc.description.references Hu, T., Wu, Y., Zhao, X., Wang, L., Bi, L., Ma, P. X., & Guo, B. (2019). Micropatterned, electroactive, and biodegradable poly(glycerol sebacate)-aniline trimer elastomer for cardiac tissue engineering. Chemical Engineering Journal, 366, 208-222. doi:10.1016/j.cej.2019.02.072 es_ES
dc.description.references Wu, Y., Wang, L., Hu, T., Ma, P. X., & Guo, B. (2018). Conductive micropatterned polyurethane films as tissue engineering scaffolds for Schwann cells and PC12 cells. Journal of Colloid and Interface Science, 518, 252-262. doi:10.1016/j.jcis.2018.02.036 es_ES
dc.description.references Wu, Y., Wang, L., Guo, B., & X Ma, P. (2014). Injectable biodegradable hydrogels and microgels based on methacrylated poly(ethylene glycol)-co-poly(glycerol sebacate) multi-block copolymers: synthesis, characterization, and cell encapsulation. Journal of Materials Chemistry B, 2(23), 3674. doi:10.1039/c3tb21716g es_ES
dc.description.references Gultekinoglu, M., Öztürk, Ş., Chen, B., Edirisinghe, M., & Ulubayram, K. (2019). Preparation of poly(glycerol sebacate) fibers for tissue engineering applications. European Polymer Journal, 121, 109297. doi:10.1016/j.eurpolymj.2019.109297 es_ES
dc.description.references Wu, Y., Wang, L., Zhao, X., Hou, S., Guo, B., & Ma, P. X. (2016). Self-healing supramolecular bioelastomers with shape memory property as a multifunctional platform for biomedical applications via modular assembly. Biomaterials, 104, 18-31. doi:10.1016/j.biomaterials.2016.07.011 es_ES
dc.description.references Zhao, X., Wu, Y., Du, Y., Chen, X., Lei, B., Xue, Y., & Ma, P. X. (2015). A highly bioactive and biodegradable poly(glycerol sebacate)–silica glass hybrid elastomer with tailored mechanical properties for bone tissue regeneration. Journal of Materials Chemistry B, 3(16), 3222-3233. doi:10.1039/c4tb01693a es_ES
dc.description.references Nagata, M., Machida, T., Sakai, W., & Tsutsumi, N. (1999). Synthesis, characterization, and enzymatic degradation of network aliphatic copolyesters. Journal of Polymer Science Part A: Polymer Chemistry, 37(13), 2005-2011. doi:10.1002/(sici)1099-0518(19990701)37:13<2005::aid-pola14>3.0.co;2-h es_ES
dc.description.references Kemppainen, J. M., & Hollister, S. J. (2010). Tailoring the mechanical properties of 3D-designed poly(glycerol sebacate) scaffolds for cartilage applications. Journal of Biomedical Materials Research Part A, 94A(1), 9-18. doi:10.1002/jbm.a.32653 es_ES
dc.description.references Conejero-García, Á., Gimeno, H. R., Sáez, Y. M., Vilariño-Feltrer, G., Ortuño-Lizarán, I., & Vallés-Lluch, A. (2017). Correlating synthesis parameters with physicochemical properties of poly(glycerol sebacate). European Polymer Journal, 87, 406-419. doi:10.1016/j.eurpolymj.2017.01.001 es_ES
dc.description.references Ravichandran, R., Venugopal, J. R., Mukherjee, S., Sundarrajan, S., & Ramakrishna, S. (2015). Elastomeric Core/Shell Nanofibrous Cardiac Patch as a Biomimetic Support for Infarcted Porcine Myocardium. Tissue Engineering Part A, 21(7-8), 1288-1298. doi:10.1089/ten.tea.2014.0265 es_ES
dc.description.references Gao, J., Crapo, P. M., & Wang, Y. (2006). Macroporous Elastomeric Scaffolds with Extensive Micropores for Soft Tissue Engineering. Tissue Engineering, 12(4), 917-925. doi:10.1089/ten.2006.12.917 es_ES
dc.description.references Mitsak, A. G., Dunn, A. M., & Hollister, S. J. (2012). Mechanical characterization and non-linear elastic modeling of poly(glycerol sebacate) for soft tissue engineering. Journal of the Mechanical Behavior of Biomedical Materials, 11, 3-15. doi:10.1016/j.jmbbm.2011.11.003 es_ES
dc.description.references Hsu, C.-N., Lee, P.-Y., Tuan-Mu, H.-Y., Li, C.-Y., & Hu, J.-J. (2017). Fabrication of a mechanically anisotropic poly(glycerol sebacate) membrane for tissue engineering. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 106(2), 760-770. doi:10.1002/jbm.b.33876 es_ES
dc.description.references Li, X., Hong, A. T.-L., Naskar, N., & Chung, H.-J. (2015). Criteria for Quick and Consistent Synthesis of Poly(glycerol sebacate) for Tailored Mechanical Properties. Biomacromolecules, 16(5), 1525-1533. doi:10.1021/acs.biomac.5b00018 es_ES
dc.description.references Aydin, H. M., Salimi, K., Rzayev, Z. M. O., & Pişkin, E. (2013). Microwave-assisted rapid synthesis of poly(glycerol-sebacate) elastomers. Biomaterials Science, 1(5), 503. doi:10.1039/c3bm00157a es_ES
dc.description.references Lau, C. C., Bayazit, M. K., Knowles, J. C., & Tang, J. (2017). Tailoring degree of esterification and branching of poly(glycerol sebacate) by energy efficient microwave irradiation. Polymer Chemistry, 8(26), 3937-3947. doi:10.1039/c7py00862g es_ES
dc.description.references Bhanu, V. A., & Kishore, K. (1991). Role of oxygen in polymerization reactions. Chemical Reviews, 91(2), 99-117. doi:10.1021/cr00002a001 es_ES
dc.description.references Conley, R. T. (1967). Studies of the Stability of Condensation Polymers in Oxygen-Containing Atmospheres. Journal of Macromolecular Science: Part A - Chemistry, 1(1), 81-106. doi:10.1080/10601326708053918 es_ES
dc.description.references SZWARC, M. (1956). ‘Living’ Polymers. Nature, 178(4543), 1168-1169. doi:10.1038/1781168a0 es_ES
dc.description.references Chen, Q.-Z., Bismarck, A., Hansen, U., Junaid, S., Tran, M. Q., Harding, S. E., … Boccaccini, A. R. (2008). Characterisation of a soft elastomer poly(glycerol sebacate) designed to match the mechanical properties of myocardial tissue. Biomaterials, 29(1), 47-57. doi:10.1016/j.biomaterials.2007.09.010 es_ES
dc.description.references Vallés-Lluch, A., Gallego Ferrer, G., & Monleón Pradas, M. (2010). Effect of the silica content on the physico-chemical and relaxation properties of hybrid polymer/silica nanocomposites of P(EMA-co-HEA). European Polymer Journal, 46(5), 910-917. doi:10.1016/j.eurpolymj.2010.02.004 es_ES
dc.description.references Gaharwar, A. K., Patel, A., Dolatshahi-Pirouz, A., Zhang, H., Rangarajan, K., Iviglia, G., … Khademhosseini, A. (2015). Elastomeric nanocomposite scaffolds made from poly(glycerol sebacate) chemically crosslinked with carbon nanotubes. Biomaterials Science, 3(1), 46-58. doi:10.1039/c4bm00222a es_ES
dc.description.references Chen, Q., Liang, S., & Thouas, G. A. (2013). Elastomeric biomaterials for tissue engineering. Progress in Polymer Science, 38(3-4), 584-671. doi:10.1016/j.progpolymsci.2012.05.003 es_ES
dc.description.references Ma, Y., Feng, X., Rogers, J. A., Huang, Y., & Zhang, Y. (2017). Design and application of ‘J-shaped’ stress–strain behavior in stretchable electronics: a review. Lab on a Chip, 17(10), 1689-1704. doi:10.1039/c7lc00289k es_ES
dc.description.references Ifkovits, J. L., Padera, R. F., & Burdick, J. A. (2008). Biodegradable and radically polymerized elastomers with enhanced processing capabilities. Biomedical Materials, 3(3), 034104. doi:10.1088/1748-6041/3/3/034104 es_ES


Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem