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Production and enzymatic degradation of poly (epsilon-caprolactone)/graphene oxide composites

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Production and enzymatic degradation of poly (epsilon-caprolactone)/graphene oxide composites

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dc.contributor.author Martínez-Ramón, V. es_ES
dc.contributor.author Castilla Cortázar, María Isabel Cecilia es_ES
dc.contributor.author Vidaurre, Ana es_ES
dc.contributor.author CAMPILLO FERNANDEZ, ALBERTO JOSE es_ES
dc.date.accessioned 2021-09-09T03:33:39Z
dc.date.available 2021-09-09T03:33:39Z
dc.date.issued 2020-06 es_ES
dc.identifier.issn 2158-5849 es_ES
dc.identifier.uri http://hdl.handle.net/10251/171675
dc.description.abstract [EN] Poly(epsilon-caprolactone) (PCL) based composites containing different graphene oxide (GO) contents (0.1, 0.2 and 0.5 wt%) were produced by the solution mixing method followed by compression molding and enzymatically degraded in a pH 7.4 phosphate buffer solution containing Pseudomonas lipase at 37 degrees C. Morphological changes, molecular weight, calorimetric and mechanical properties were analyzed according to graphene oxide content. The study of tensile properties showed that the composites increased their Young's modulus, while tensile strength and elongation at break decreased to significantly less than that of neat PCL. PCL composite crystallinity was evaluated by differential scanning calorimetry (DSC). It was found that incorporating GO can reduce nucleation activity as well as crystallization rates, from 67.6% for neat PCL to 50.6% for a composite with 0.5 wt% GO content. For enzymatic degradation, the weight loss data showed that incorporating GO into the PCL significantly altered enzymatic degradation. The presence of GO did not alter PCL's hydrolysis mechanism, but did slow down composite enzymatic degradation in proportion to the percentage of filler content. es_ES
dc.description.sponsorship I. Castilla-Cortazar and A. J. Campillo-Fernandez are grateful for the support of the Spanish Ministry of Science, Innovation and Universities, through RTE2018-095872-13-C22/ERDF. A. Vidaurre would like to express her gratitude for the support of the Spanish Ministry of Science and Education, through the MAT2016-76039-C4-1-R Project, and also the support from CIBER-BBN, an initiative funded by the Sixth National R&D&i Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program, CIBER Actions financed by the Institute de Salud Carlos III with assistance from the European Regional Development Fund. The FESEM, TEM and mechanical tests were conducted by the authors at the Microscopy Service of the Universitat Politecnica de Valencia, whose advice is greatly appreciated, es_ES
dc.language Inglés es_ES
dc.publisher American Scientific Publishers es_ES
dc.relation.ispartof Materials Express es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Polycaprolactone es_ES
dc.subject Graphene oxide es_ES
dc.subject Enzymatic degradation es_ES
dc.subject Pseudomonas lipase es_ES
dc.subject Molecular weight es_ES
dc.subject Morphology es_ES
dc.subject Mechanical properties es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.subject.classification FISICA APLICADA es_ES
dc.title Production and enzymatic degradation of poly (epsilon-caprolactone)/graphene oxide composites es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1166/mex.2020.1702 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2016-76039-C4-1-R/ES/BIOMATERIALES PIEZOELECTRICOS PARA LA DIFERENCIACION CELULAR EN INTERFASES CELULA-MATERIAL ELECTRICAMENTE ACTIVAS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-095872-B-C22/ES/NUEVO DISPOSITIVO BIOACTIVO PARA LA REGENERACION DE LESIONES DE LA MEDULA ESPINAL./ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada es_ES
dc.description.bibliographicCitation Martínez-Ramón, V.; Castilla Cortázar, MIC.; Vidaurre, A.; Campillo Fernandez, AJ. (2020). Production and enzymatic degradation of poly (epsilon-caprolactone)/graphene oxide composites. Materials Express. 10(6):866-876. https://doi.org/10.1166/mex.2020.1702 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1166/mex.2020.1702 es_ES
dc.description.upvformatpinicio 866 es_ES
dc.description.upvformatpfin 876 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 10 es_ES
dc.description.issue 6 es_ES
dc.relation.pasarela S\415824 es_ES
dc.contributor.funder Instituto de Salud Carlos III es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
dc.contributor.funder Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina es_ES


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