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Hydrolytic stability and biocompatibility on smooth muscle cells of polyethylene glycol-polycaprolactone-based polyurethanes

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Hydrolytic stability and biocompatibility on smooth muscle cells of polyethylene glycol-polycaprolactone-based polyurethanes

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dc.contributor.author Morales-Gonzalez, Maria es_ES
dc.contributor.author Arévalo-Alquichire, Said es_ES
dc.contributor.author Diaz, Luis E. es_ES
dc.contributor.author Sans-Tresserras, Juan Ángel es_ES
dc.contributor.author Vilariño, Guillermo es_ES
dc.contributor.author Gómez-Tejedor, José-Antonio es_ES
dc.contributor.author Valero, Manuel F. es_ES
dc.date.accessioned 2021-09-14T03:33:48Z
dc.date.available 2021-09-14T03:33:48Z
dc.date.issued 2020-12-14 es_ES
dc.identifier.issn 0884-2914 es_ES
dc.identifier.uri http://hdl.handle.net/10251/172319
dc.description.abstract [EN] Interactions between smooth muscle cells (SMCs) and biomaterials must not result in phenotype changes as this may generate uncontrolled multiplication processes and occlusions in vascular grafts. The aim of this study was to relate the hydrolytic stability and biocompatibility of polyurethanes (PUs) on SMCs. A higher polycaprolactone (PCL) concentration was found to improve the hydrolytic stability of the material and the adhesion of SMCs. A material with 5% polyethylene glycol, 90% PCL, and 5% pentaerythritol presented high cell viability and adhesion, suggesting a contractile phenotype in SMCs depending on the morphology. Nevertheless, all PUs retained their elastic modulus over 120 days, similar to the collagen of native arteries (similar to 10 MPa). Furthermore, aortic SMCs did not present toxicity (viability over 80%) and demonstrated adherence without any abnormal cell multiplication processes, which is ideal for the function to be fulfiled in situ in the vascular grafts. es_ES
dc.description.sponsorship The research and publication were supported by the Universidad de La Sabana (ING-205-2018) and the Minister of Science, Technology, and Innovation of the Republic of Colombia, MINCIENCAS (Contract number 80740-186-2019). M. M-G. would like to thank the Universidad de La Sabana for the scholarship for her master's studies. S. A-A. would like to thank MINCIENCIAS for the doctoral training scholarship (Grant 727-2015). The authors are thankful to Professor Ericsson Coy Barrera and his staff at Nueva Granada Military University for the access to the VarioskanT LUX multimode microplate reader. J. A. S. acknowledges the financial support by MINECO through FIS2017-83295-P, MAT2015-71070-REDC, MAT2016-75586-C4-1/2/3-P and the Ramon y Cajal Fellowship (RYC-201517482). CIBER-BBN is an initiative funded by the VI National R&D&I Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program. CIBER actions are financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. es_ES
dc.language Inglés es_ES
dc.publisher Cambridge University Press (Materials Research Society) es_ES
dc.relation.ispartof Journal of Materials Research es_ES
dc.rights Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) es_ES
dc.subject Hydrolytic stability es_ES
dc.subject Biocompatibility es_ES
dc.subject Polyurethan es_ES
dc.subject Polyethylene glycol-polycaprolactone es_ES
dc.subject.classification FISICA APLICADA es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title Hydrolytic stability and biocompatibility on smooth muscle cells of polyethylene glycol-polycaprolactone-based polyurethanes es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1557/jmr.2020.303 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/Universidad de La Sabana//ING-202-2018/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2015-71070-REDC/ES/MATERIA A ALTA PRESION. MALTA-CONSOLIDER TEAM/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/Minciencias//80740-186-2019/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//RYC-2015-17482/ES/RYC-2015-17482/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/Minciencias//727-2015/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2016-75586-C4-1-P/ES/OXIDOS METALICOS BAJO CONDICIONES EXTREMAS: SINTESIS Y CARACTERIZACION DE MATERIALES EN VOLUMEN, NANOCRISTALES Y CAPAS DELGADAS CON APLICACIONES TECNOLOGICAS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2016-75586-C4-3-P/ES/ESTUDIO AB INITIO DE COMPUESTOS ABX4, ABO3, A2X3, PEROVSKITAS Y NANOMATERIALES BAJO CONDICIONES EXTREMAS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2016-75586-C4-2-P/ES/COMPUESTOS ABO3 Y A2X3 EN CONDICIONES EXTREMAS DE PRESION Y TEMPERATURA/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/FIS2017-83295-P/ES/EN BUSCA DE LA REACCION DEL HELIO EN CONDICIONES EXTREMAS/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Diseño para la Fabricación y Producción Automatizada - Institut de Disseny per a la Fabricació i Producció Automatitzada es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada es_ES
dc.description.bibliographicCitation Morales-Gonzalez, M.; Arévalo-Alquichire, S.; Diaz, LE.; Sans-Tresserras, JÁ.; Vilariño, G.; Gómez-Tejedor, J.; Valero, MF. (2020). Hydrolytic stability and biocompatibility on smooth muscle cells of polyethylene glycol-polycaprolactone-based polyurethanes. Journal of Materials Research. 35(23-24):3276-3285. https://doi.org/10.1557/jmr.2020.303 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1557/jmr.2020.303 es_ES
dc.description.upvformatpinicio 3276 es_ES
dc.description.upvformatpfin 3285 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 35 es_ES
dc.description.issue 23-24 es_ES
dc.relation.pasarela S\421783 es_ES
dc.contributor.funder Universidad de La Sabana es_ES
dc.contributor.funder Instituto de Salud Carlos III es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación, Colombia es_ES
dc.contributor.funder Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina es_ES
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