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Pathological changes and antigen localization in the small intestine of rabbits infected with Eimeria magna

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Pathological changes and antigen localization in the small intestine of rabbits infected with Eimeria magna

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dc.contributor.author Yuan, X. es_ES
dc.contributor.author Liu, J. es_ES
dc.contributor.author Wang, F. es_ES
dc.contributor.author Hu, X. F. es_ES
dc.contributor.author Wen, F. es_ES
dc.contributor.author Tang, X. E. es_ES
dc.contributor.author Yang, S. S. es_ES
dc.contributor.author Zhong, S. W. es_ES
dc.contributor.author Zhou, Z. H. es_ES
dc.contributor.author Li, Yong es_ES
dc.date.accessioned 2021-10-01T08:38:28Z
dc.date.available 2021-10-01T08:38:28Z
dc.date.issued 2021-09-30
dc.identifier.issn 1257-5011
dc.identifier.uri http://hdl.handle.net/10251/173608
dc.description.abstract [EN] Coccidiosis is a major disease caused by various Eimeria species in rabbits. The aim of the present study was to investigate the haematological and pathological changes in rabbits infected with E. magna. Moreover, the localisation of coccidial antigens was examined in the intestines of rabbits with two kinds of serum as primary antibodies. In the present study, forty-five 28-day-old weaned rabbits were randomly divided into three groups and reared in three separate places. Group A was infected with 20×103 sporulated oocysts of E. magna, group B was only used to produce anti-E. intestinalis serum by infecting them with 3×103 sporulated oocysts of E. intestinalis, and group C was designated as the control group. According to histopathological evaluation of group A, the epithelial cells of the jejunum and ileum were parasitised with a large number of oocysts and other stages of E. magna. The haematological results showed that red blood cell counts, haemoglobin counts, haematocrit levels and the percentage of lymphocytes were significantly decreased in group A compared with group C (P<0.01), but white blood cell counts and the percentage of neutrophils were significantly increased (P<0.01). The weight of group A began to decrease on the 5th day after infection, and this decrease continued until the 9th day. Immunohistochemistry staining revealed that two kinds of coccidial antigens were basically located at the same sites of the intestine when anti-E. intestinalis serum and anti-E. magna serum were used as primary antibodies. Most likely, E. magna and E. intestinalis antigens have some similar antigenic determinants; this finding provides a theoretical basis for screening for common antigens of these two coccidian species. es_ES
dc.description.sponsorship This study was supported by grants from the National Natural Science Foundation Project of China (nos.31960688 and 31360592) and the Natural Science Foundation Project of Jiangxi Province (no. 20181BAB204016). es_ES
dc.language Inglés es_ES
dc.publisher Universitat Politècnica de València es_ES
dc.relation.ispartof World Rabbit Science es_ES
dc.rights Reconocimiento - No comercial - Compartir igual (by-nc-sa) es_ES
dc.subject E. magna es_ES
dc.subject E. intestinalis es_ES
dc.subject Oryctolagus cuniculus es_ES
dc.subject Antigen detection es_ES
dc.subject Intestinal histopathology es_ES
dc.title Pathological changes and antigen localization in the small intestine of rabbits infected with Eimeria magna es_ES
dc.type Artículo es_ES
dc.relation.projectID info:eu-repo/grantAgreement/NSFC//31960688/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/NSFC//31360592/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/Natural Science Foundation of Jiangxi Province//20181BAB204016/ es_ES
dc.rights.accessRights Abierto es_ES
dc.description.bibliographicCitation Yuan, X.; Liu, J.; Wang, F.; Hu, XF.; Wen, F.; Tang, XE.; Yang, SS.... (2021). Pathological changes and antigen localization in the small intestine of rabbits infected with Eimeria magna. World Rabbit Science. 29(3):183-192. http://hdl.handle.net/10251/173608 es_ES
dc.description.accrualMethod OJS es_ES
dc.description.upvformatpinicio 183 es_ES
dc.description.upvformatpfin 192 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 29 es_ES
dc.description.issue 3 es_ES
dc.identifier.eissn 1989-8886
dc.relation.pasarela OJS\15254 es_ES
dc.contributor.funder National Natural Science Foundation of China es_ES
dc.contributor.funder Natural Science Foundation of Jiangxi Province es_ES


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