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Synthesis of bodinieric acids A and B, both C-18 and C-19-functionalized abietane diterpenoids: DFT study of the key aldol reaction

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Synthesis of bodinieric acids A and B, both C-18 and C-19-functionalized abietane diterpenoids: DFT study of the key aldol reaction

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dc.contributor.author Zaragoza, Ramon J. es_ES
dc.contributor.author González-Cardenete, Miguel A es_ES
dc.date.accessioned 2021-11-05T12:27:21Z
dc.date.available 2021-11-05T12:27:21Z
dc.date.issued 2020-04-15 es_ES
dc.identifier.uri http://hdl.handle.net/10251/176087
dc.description.abstract [EN] The first synthesis of C-18- and C-19-bifunctionalized abietane diterpenoids, bodinieric (or callicapoic) acids, via an aldol reaction has been developed. This key aldol reaction was very sensitive to steric hindrance. This fact has been studied by deuterium exchange experiments and DFT methods. Optimization of this reaction led to the synthesis of anti-inflammatory bodinieric acids A and B, starting from abietic acid es_ES
dc.description.sponsorship Financial support has been provided by the Spanish Government [CSIC (201680I008)] and the Universidad de Valencia, Spain es_ES
dc.language Inglés es_ES
dc.publisher The Royal Society of Chemistry es_ES
dc.relation.ispartof RSC Advances es_ES
dc.rights Reconocimiento (by) es_ES
dc.title Synthesis of bodinieric acids A and B, both C-18 and C-19-functionalized abietane diterpenoids: DFT study of the key aldol reaction es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1039/d0ra02711a es_ES
dc.relation.projectID info:eu-repo/grantAgreement/CSIC//201680I008/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/UPV.CCD//AD1902//DISEÑO, DESARROLO Y CARACTERIZACION DE ANTIVIRALES FLUORESCENTES DE PRODUCCION SOSTENIBLE PARA ENFERMEDADES TROPICALES Y CO-INFECCIONES OPORTUNISTAS EN VIH DE ALTA PREVALENCIA EN AMERICA LATINA./ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Tecnología Química - Institut Universitari Mixt de Tecnologia Química es_ES
dc.description.bibliographicCitation Zaragoza, RJ.; González-Cardenete, MA. (2020). Synthesis of bodinieric acids A and B, both C-18 and C-19-functionalized abietane diterpenoids: DFT study of the key aldol reaction. RSC Advances. 10(25):15015-15022. https://doi.org/10.1039/d0ra02711a es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1039/d0ra02711a es_ES
dc.description.upvformatpinicio 15015 es_ES
dc.description.upvformatpfin 15022 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 10 es_ES
dc.description.issue 25 es_ES
dc.identifier.eissn 2046-2069 es_ES
dc.relation.pasarela S\414990 es_ES
dc.contributor.funder UNIVERSIDAD POLITECNICA DE VALENCIA es_ES
dc.contributor.funder Consejo Superior de Investigaciones Científicas es_ES


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