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Simultaneous imaging of hard and soft biological tissues in a low-field dental MRI scanner

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Simultaneous imaging of hard and soft biological tissues in a low-field dental MRI scanner

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dc.contributor.author Algarín-Guisado, José Miguel es_ES
dc.contributor.author Díaz-Caballero, Elena es_ES
dc.contributor.author Borreguero-Morata, José es_ES
dc.contributor.author Galve, Fernando es_ES
dc.contributor.author Grau-Ruiz, Daniel es_ES
dc.contributor.author Rigla, Juan P. es_ES
dc.contributor.author Bosch-Esteve, Rubén es_ES
dc.contributor.author González-Hernández, José Manuel es_ES
dc.contributor.author Pallás, Eduardo es_ES
dc.contributor.author Corberán, Miguel es_ES
dc.contributor.author Gramage, Carlos es_ES
dc.contributor.author Aja-Fernández, Santiago es_ES
dc.contributor.author Ríos, Alfonso es_ES
dc.contributor.author Benlloch Baviera, Jose María es_ES
dc.contributor.author Alonso, Joseba es_ES
dc.date.accessioned 2021-11-05T12:57:44Z
dc.date.available 2021-11-05T12:57:44Z
dc.date.issued 2020-12-08 es_ES
dc.identifier.issn 2045-2322 es_ES
dc.identifier.uri http://hdl.handle.net/10251/176174
dc.description.abstract [EN] Magnetic Resonance Imaging (MRI) of hard biological tissues is challenging due to the fleeting lifetime and low strength of their response to resonant stimuli, especially at low magnetic fields. Consequently, the impact of MRI on some medical applications, such as dentistry, continues to be limited. Here, we present three-dimensional reconstructions of ex-vivo human teeth, as well as a rabbit head and part of a cow femur, all obtained at a field strength of 260 mT. These images are the first featuring soft and hard tissues simultaneously at sub-Tesla fields, and they have been acquired in a home-made, special-purpose, pre-medical MRI scanner designed with the goal of demonstrating dental imaging at low field settings. We encode spatial information with two pulse sequences: Pointwise-Encoding Time reduction with Radial Acquisition and a new sequence we have called Double Radial Non-Stop Spin Echo, which we find to perform better than the former. For image reconstruction we employ Algebraic Reconstruction Techniques (ART) as well as standard Fourier methods. An analysis of the resulting images shows that ART reconstructions exhibit a higher signal-to-noise ratio with a more homogeneous noise distribution. es_ES
dc.description.sponsorship We thank anonymous donors for their tooth samples, Andrew Webb and Thomas O'Reilly (LUMC) for discussions on hardware and pulse sequences, and Antonio Tristan (UVa) for information on reconstruction techniques. This work was supported by the European Commission under Grants 737180 (FET-OPEN: HISTO-MRI) and 481 (ATTRACT: DentMRI). Action co-financed by the European Union through the Programa Operativo del Fondo Europeo de Desarrollo Regional (FEDER) of the Comunitat Valenciana 2014-2020 (IDIFEDER/2018/022). Santiago Aja-Fernandez acknowledges Ministerio de Ciencia e Innovacion of Spain for research grant RTI2018-094569-B-I00. es_ES
dc.language Inglés es_ES
dc.publisher Nature Publishing Group es_ES
dc.relation.ispartof Scientific Reports es_ES
dc.rights Reconocimiento (by) es_ES
dc.title Simultaneous imaging of hard and soft biological tissues in a low-field dental MRI scanner es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1038/s41598-020-78456-2 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/737180/EU/IN SITU IMAGING OF LIVING TISSUES WITH CELLULAR SPATIAL RESOLUTION/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI//RTI2018-094569-B-I00//RESONANCIA MAGNETICA DE DIFUSION PARA MEDICINA PERSONALIZADA: DEL ANALISIS A LA PREDICCION. APLICACION AL ESTUDIO DE MIGRAÑA/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//IDIFEDER%2F2018%2F022//EQUIPOS PARA TECNICAS MIXTAS ELECTROMAGNETICAS-ULTRASONICAS PARA IMAGEN MEDICA/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Instrumentación para Imagen Molecular - Institut d'Instrumentació per a Imatge Molecular es_ES
dc.description.bibliographicCitation Algarín-Guisado, JM.; Díaz-Caballero, E.; Borreguero-Morata, J.; Galve, F.; Grau-Ruiz, D.; Rigla, JP.; Bosch-Esteve, R.... (2020). Simultaneous imaging of hard and soft biological tissues in a low-field dental MRI scanner. Scientific Reports. 10(1):1-14. https://doi.org/10.1038/s41598-020-78456-2 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1038/s41598-020-78456-2 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 14 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 10 es_ES
dc.description.issue 1 es_ES
dc.identifier.pmid 33293593 es_ES
dc.identifier.pmcid PMC7723060 es_ES
dc.relation.pasarela S\431221 es_ES
dc.contributor.funder European Commission es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
dc.contributor.funder European Regional Development Fund es_ES
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