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Neo-antigens for the serological diagnosis of IgE-mediated drug allergic reactions to antibiotics cephalosporin, carbapenem and monobactam

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Neo-antigens for the serological diagnosis of IgE-mediated drug allergic reactions to antibiotics cephalosporin, carbapenem and monobactam

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dc.contributor.author Peña-Mendizábal, Edurne es_ES
dc.contributor.author Morais, Sergi es_ES
dc.contributor.author Maquieira Catala, Ángel es_ES
dc.date.accessioned 2021-11-05T12:57:54Z
dc.date.available 2021-11-05T12:57:54Z
dc.date.issued 2020-09-29 es_ES
dc.identifier.issn 2045-2322 es_ES
dc.identifier.uri http://hdl.handle.net/10251/176180
dc.description.abstract [EN] New antigens deriving from -lloyl and -llanyl, major and minor determinants, respectively, were produced for beta-lactam antibiotics cefuroxime, cefotaxime, ceftriaxone, meropenem and aztreonam. Twenty beta-lactam antigens were produced using human serum albumin and histone H1 as carrier proteins. Antigens were tested by multiplex in vitro immunoassays and evaluated based on the detection of specific IgG and IgE in the serum samples. Both major and minor determinants were appropriate antigens for detecting specific anti-beta-lactam IgG in immunised rabbit sera. In a cohort of 37 allergic patients, we observed that only the minor determinants (-llanyl antigens) were suitable for determining specific anti-beta-lactam IgE antibodies with high sensitivity (<0.01 IU/mL; 24 ng/L) and specificity (100%). These findings reveal that not only the haptenisation of beta-lactam antibiotics renders improved molecular recognition events when the 4-member beta-lactam ring remains unmodified, but also may contribute to develop promising minor antigens suitable for detecting specific IgE-mediated allergic reactions. This will facilitate the development of sensitive and selective multiplexed in vitro tests for drug-allergy diagnoses to antibiotics cephalosporin, carbapenem and monobactam. es_ES
dc.description.sponsorship This work has been funded by the H2020 programme (Project COBIOPHAD, grant agreement No. 688448), and is an initiative of the Photonics Public Private Partnership (www.photonics21.org); Agencia Estatal de Investigacion (CTQ2016-75749-R, FEDER) and programme UPV-LA FE 2019 (PI05 VALBIOAL). The authors acknowledge the Instituto de Investigacion Sanitaria La Fe, Valencia, Spain, which provided the samples from both allergic patients and controls. E.P.M acknowledges an FPU grant from the Ministerio de Educacion, Cultura y Deporte. es_ES
dc.language Inglés es_ES
dc.publisher Nature Publishing Group es_ES
dc.relation.ispartof Scientific Reports es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject.classification QUIMICA ANALITICA es_ES
dc.title Neo-antigens for the serological diagnosis of IgE-mediated drug allergic reactions to antibiotics cephalosporin, carbapenem and monobactam es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1038/s41598-020-73109-w es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/688448/EU/COMPACT BIOPHOTONIC PLATFORM FOR DRUG ALLERGY DIAGNOSIS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI//CTQ2016-75749-R//BIOSENSORES HOLOGRAFICOS. PRUEBA DE CONCEPTO Y DEMOSTRACION EN APLICACIONES CLINICAS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/UNIVERSIDAD POLITECNICA DE VALENCIA//UPV-FE-PI05//VALIDACION DE UN SISTEMA BIOFOTONICO PARA EL DIAGNOSTICO IN VITRO DE ALERGIA A ANTIBIOTICOS/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.description.bibliographicCitation Peña-Mendizábal, E.; Morais, S.; Maquieira Catala, Á. (2020). Neo-antigens for the serological diagnosis of IgE-mediated drug allergic reactions to antibiotics cephalosporin, carbapenem and monobactam. Scientific Reports. 10(1):1-12. https://doi.org/10.1038/s41598-020-73109-w es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1038/s41598-020-73109-w es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 12 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 10 es_ES
dc.description.issue 1 es_ES
dc.identifier.pmid 32994501 es_ES
dc.identifier.pmcid PMC7525514 es_ES
dc.relation.pasarela S\418574 es_ES
dc.contributor.funder European Commission es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder UNIVERSIDAD POLITECNICA DE VALENCIA es_ES
dc.contributor.funder Ministerio de Educación, Cultura y Deporte es_ES
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