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Radiofrequency ablation combined with conductive fluid-based dopants (saline normal and colloidal gold): computer modeling and ex vivo experiments

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Radiofrequency ablation combined with conductive fluid-based dopants (saline normal and colloidal gold): computer modeling and ex vivo experiments

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dc.contributor.author Castro-López, Dora Luz es_ES
dc.contributor.author Berjano, Enrique es_ES
dc.contributor.author Romero-Méndez, Ricardo es_ES
dc.date.accessioned 2021-11-05T14:08:04Z
dc.date.available 2021-11-05T14:08:04Z
dc.date.issued 2021-01-06 es_ES
dc.identifier.issn 1475-925X es_ES
dc.identifier.uri http://hdl.handle.net/10251/176313
dc.description.abstract [EN] Background: The volume of the coagulation zones created during radiofrequency ablation (RFA) is limited by the appearance of roll-off. Doping the tissue with conductive fluids, e.g., gold nanoparticles (AuNPs) could enlarge these zones by delaying roll-off. Our goal was to characterize the electrical conductivity of a substrate doped with AuNPs in a computer modeling study and ex vivo experiments to investigate their effect on coagulation zone volumes. Methods: The electrical conductivity of substrates doped with normal saline or AuNPs was assessed experimentally on agar phantoms. The computer models, built and solved on COMSOL Multiphysics, consisted of a cylindrical domain mimicking liver tissue and a spherical domain mimicking a doped zone with 2, 3 and 4 cm diameters. Ex vivo experiments were conducted on bovine liver fragments under three different conditions: non-doped tissue (ND Group), 2 mL of 0.9% NaCl (NaCl Group), and 2 mL of AuNPs 0.1 wt% (AuNPs Group). Results: The theoretical analysis showed that adding normal saline or colloidal gold in concentrations lower than 10% only modifies the electrical conductivity of the doped substrate with practically no change in the thermal characteristics. The computer results showed a relationship between doped zone size and electrode length regarding the created coagulation zone. There was good agreement between the ex vivo and computational results in terms of transverse diameter of the coagulation zone. Conclusions: Both the computer and ex vivo experiments showed that doping with AuNPs can enlarge the coagulation zone, especially the transverse diameter and hence enhance sphericity. es_ES
dc.description.sponsorship This work was supported by the National Council of Science and Technology (CONACYT, Mexico) through a scholarship grant to Dora Luz Castro-Lopez, CVU Registration No. 446604; and by the Spanish Ministerio de Ciencia, Innovacion y Universidades under the "Plan Estatal de Investigacion, Desarrollo e Innovacion Orientada a los Retos de la Sociedad", Grant No "RTI2018-094357-B-C21" es_ES
dc.language Inglés es_ES
dc.publisher Springer (Biomed Central Ltd.) es_ES
dc.relation.ispartof BioMedical Engineering OnLine es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Gold nanoparticles es_ES
dc.subject Nanofluid es_ES
dc.subject Saline solution es_ES
dc.subject Radiofrequency ablation es_ES
dc.subject.classification TECNOLOGIA ELECTRONICA es_ES
dc.title Radiofrequency ablation combined with conductive fluid-based dopants (saline normal and colloidal gold): computer modeling and ex vivo experiments es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1186/s12938-020-00842-8 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-094357-B-C21/ES/MODELADO Y EXPERIMENTACION PARA TERAPIAS ABLATIVAS INNOVADORAS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/CONACYT//446604/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica es_ES
dc.description.bibliographicCitation Castro-López, DL.; Berjano, E.; Romero-Méndez, R. (2021). Radiofrequency ablation combined with conductive fluid-based dopants (saline normal and colloidal gold): computer modeling and ex vivo experiments. BioMedical Engineering OnLine. 20:1-20. https://doi.org/10.1186/s12938-020-00842-8 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1186/s12938-020-00842-8 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 20 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 20 es_ES
dc.identifier.pmid 33407532 es_ES
dc.identifier.pmcid PMC7788784 es_ES
dc.relation.pasarela S\425311 es_ES
dc.contributor.funder AGENCIA ESTATAL DE INVESTIGACION es_ES
dc.contributor.funder Consejo Nacional de Ciencia y Tecnología, México es_ES
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