De Santis, S.; Cosa-Liñán, A.; Garcia-Hernandez, R.; Dmytrenko, L.; Vargova, L.; Vorisek, I.; Stopponi, S.... (2020). Chronic alcohol consumption alters extracellular space geometry and transmitter diffusion in the brain. Science Advances. 6(26):1-12. https://doi.org/10.1126/sciadv.aba0154
Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/177258
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Título:
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Chronic alcohol consumption alters extracellular space geometry and transmitter diffusion in the brain
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Autor:
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De Santis, Silvia
Cosa-Liñán, Alejandro
Garcia-Hernandez, Raquel
Dmytrenko, Lesia
Vargova, Lydia
Vorisek, Ivan
Stopponi, Serena
Bach, Patrick
Kirsch, Peter
Kiefer, Falk
Ciccocioppo, Roberto
Sykova, Eva
Moratal, David
Sommer, Wolfgang H.
Canals, Santiago
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Entidad UPV:
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Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica
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Fecha difusión:
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Resumen:
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[EN] Already moderate alcohol consumption has detrimental long-term effects on brain function. However, how alcohol produces its potent addictive effects despite being a weak reinforcer is a poorly understood conundrum ...[+]
[EN] Already moderate alcohol consumption has detrimental long-term effects on brain function. However, how alcohol produces its potent addictive effects despite being a weak reinforcer is a poorly understood conundrum that likely hampers the development of successful interventions to limit heavy drinking. In this translational study, we demonstrate widespread increased mean diffusivity in the brain gray matter of chronically drinking humans and rats. These alterations appear soon after drinking initiation in rats, persist into early abstinence in both species, and are associated with a robust decrease in extracellular space tortuosity explained by a microglial reaction. Mathematical modeling of the diffusivity changes unveils an increased spatial reach of extrasynaptically released transmitters like dopamine that may contribute to alcohol's progressively enhanced addictive potency
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Derechos de uso:
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Reconocimiento (by)
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Fuente:
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Science Advances. (eissn:
2375-2548
)
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DOI:
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10.1126/sciadv.aba0154
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Editorial:
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American Association for the Advancement of Science
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Versión del editor:
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https://doi.org/10.1126/sciadv.aba0154
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Código del Proyecto:
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info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PGC2018-101055-B-I00/ES/PAPEL DEL NUCLEO ACCUMBENS EN LA REGULACION DE LA CONECTIVIDAD FUNCIONAL DE LARGO RECORRIDO DEL HIPOCAMPO/
...[+]
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PGC2018-101055-B-I00/ES/PAPEL DEL NUCLEO ACCUMBENS EN LA REGULACION DE LA CONECTIVIDAD FUNCIONAL DE LARGO RECORRIDO DEL HIPOCAMPO/
info:eu-repo/grantAgreement/DFG//TRR265-B08/
info:eu-repo/grantAgreement/EC/H2020/668863/EU/Systems Biology of Alcohol Addiction: Modeling and validating disease state networks in human and animal brains for understanding pathophysiolgy, predicting outcomes and improving therapy/
info:eu-repo/grantAgreement/GACR//16-10214S/
info:eu-repo/grantAgreement/EC/H2020/749506/EU/MRI Signal To Recover Unique Cerebral TissUe Response to changEs/
info:eu-repo/grantAgreement/GVA//PROMETEO%2F2019%2F015/
info:eu-repo/grantAgreement/MINECO//BFU2015-64380-C2-1-R/ES/TRATAR LA ENFERMEDAD RESINTONIZANDO LA DINAMICA DE LAS REDES CEREBRALES/
info:eu-repo/grantAgreement/MSSSI//2017I065/
info:eu-repo/grantAgreement/SRDA//APVV-17-0642/
info:eu-repo/grantAgreement/GVA//SEJI%2F2019%2F038/
info:eu-repo/grantAgreement/NIH//AA017447/
info:eu-repo/grantAgreement/BMBF//FKZ: 031L0190A/
info:eu-repo/grantAgreement/BMBF//01ZX1909CA/
info:eu-repo/grantAgreement/MINISTERIO DE CIENCIA E INNOVACIÓN - Secretaría de Estado de Investigación Dirección General de Cooperación Internacional y Relaciones Institucionales//PIM2010ERN-00679//CIRCUITOS NEURONALES DISFUNCIONALES EN ALCOHOLISMO: CONECTIVIDAD CEREBRAL COMO INDICE TERAPEUTICO/
info:eu-repo/grantAgreement/BBRF//25104/
info:eu-repo/grantAgreement/EC//FKZ 01EW1112-TRANSALC//ERA-Net NEURON program/
info:eu-repo/grantAgreement/AEI//SEV-2017-0723/
info:eu-repo/grantAgreement/MINISTERIO DE ECONOMIA Y EMPRESA//BFU2015-64380-C2-2-R//ANALISIS DE TEXTURAS EN IMAGEN CEREBRAL MULTIMODAL POR RESONANCIA MAGNETICA PARA UNA DETECCION TEMPRANA DE ALTERACIONES EN LA RED Y BIOMARCADORES DE ENFERMEDAD/
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Agradecimientos:
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This work was supported by the European Union's Horizon 2020 research and innovation program (668863-SyBil-AA) and the ERA-NET NEURON program (FKZ 01EW1112-TRANSALC and PIM2010ERN-00679), as well as the Spanish State ...[+]
This work was supported by the European Union's Horizon 2020 research and innovation program (668863-SyBil-AA) and the ERA-NET NEURON program (FKZ 01EW1112-TRANSALC and PIM2010ERN-00679), as well as the Spanish State Research Agency through the Severo Ochoa Program for Centres of Excellence in R&D (SEV-2017-0723), the Deutsche Forschungsgemeinschaft (center grant TRR265-B08), and the Czech Science Foundation (GACR; grant no. 16-10214S to L.V.). S.C. and D.M. further acknowledge financial support from the Ministerio de Economia y Competitividad (MINECO) and FEDER funds under grant nos. BFU2015-64380-C2-1-R, BFU2015-64380-C2-2-R, and PGC2018-101055-B-I00 and the Generalitat Valenciana through the Prometeo Program (PROMETEO/2019/015). S.C. also acknowledges support of the Ministerio de Sanidad, Servicios Sociales e Igualdad (#2017I065). E.S. acknowledges financial support from the Slovak Research and Development Agency (APVV-17-0642). S.D.S. is supported by a NARSAD Young Investigator Grant (grant no. 25104), by the European Research Council through a Marie Sklodowska-Curie Individual Fellowship (grant no. 749506), and by the Generalitat Valenciana grant SEJI/2019/038. R.C. is supported by the NIAAA grant AA017447. W.H.S acknowledges support from the Bundesministerium fur Bildung und Forschung (BMBF; FKZ: 031L0190A, 01ZX1909CA).
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Tipo:
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Artículo
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