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When, How, and to What Extent Are Individuals with Unresponsive Wakefulness Syndrome Able to Progress? Neurobehavioral Progress

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When, How, and to What Extent Are Individuals with Unresponsive Wakefulness Syndrome Able to Progress? Neurobehavioral Progress

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dc.contributor.author Noé Sebastián, Enrique es_ES
dc.contributor.author Ferri, Joan es_ES
dc.contributor.author Olaya, José es_ES
dc.contributor.author Navarro, María Dolores es_ES
dc.contributor.author O'Valle, Myrtha es_ES
dc.contributor.author Colomer Font, Carolina es_ES
dc.contributor.author Moliner, Belén es_ES
dc.contributor.author Ippoliti, Camilla es_ES
dc.contributor.author Maza, Anny es_ES
dc.contributor.author Llorens Rodríguez, Roberto es_ES
dc.date.accessioned 2022-02-03T19:04:46Z
dc.date.available 2022-02-03T19:04:46Z
dc.date.issued 2021-01-19 es_ES
dc.identifier.uri http://hdl.handle.net/10251/180474
dc.description.abstract [EN] Accurate estimation of the neurobehavioral progress of patients with unresponsive wakefulness syndrome (UWS) is essential to anticipate their most likely clinical course and guide clinical decision making. Although different studies have described this progress and possible predictors of neurobehavioral improvement in these patients, they have methodological limitations that could restrict the validity and generalization of the results. This study investigates the neurobehavioral progress of 100 patients with UWS consecutively admitted to a neurorehabilitation center using systematic weekly assessments based on standardized measures, and the prognostic factors of changes in their neurobehavioral condition. Our results showed that, during the analyzed period, 34% of the patients were able to progress from UWS to minimally conscious state (MCS), 12% of the total sample (near one third from those who progressed to MCS) were able to emerge from MCS, and 10% of the patients died. Transition to MCS was mostly denoted by visual signs, which appeared either alone or in combination with motor signs, and was predicted by etiology and the score on the Coma Recovery Scale-Revised at admission with an accuracy of 75%. Emergence from MCS was denoted in the same proportion by functional communication and object use. Predictive models of emergence from MCS and mortality were not valid and the identified predictors could not be accounted for es_ES
dc.description.sponsorship This research was funded by the program RISE-Marie-Slodowska-Curie of the European Commission (Grant agreement 778234), by Conselleria de Educacion, Investigacion, Cultura y Deporte of Generalitat Valenciana (SEJI/2019/017), and by Vicerrectorado de Investigacion, Innovacion y transferencia of Universitat Politecnica de Valencia (PAID-06-18) es_ES
dc.language Inglés es_ES
dc.publisher MDPI AG es_ES
dc.relation.ispartof Brain Sciences es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Unresponsive wakefulness syndrome es_ES
dc.subject Vegetative state es_ES
dc.subject Minimally conscious state es_ES
dc.subject Disorders of consciousness es_ES
dc.subject Brain damage es_ES
dc.subject Predictors es_ES
dc.subject Recovery es_ES
dc.subject Mortality es_ES
dc.subject.classification TEORIA DE LA SEÑAL Y COMUNICACIONES es_ES
dc.title When, How, and to What Extent Are Individuals with Unresponsive Wakefulness Syndrome Able to Progress? Neurobehavioral Progress es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.3390/brainsci11010126 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/778234/EU/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/UPV//PAID-06-18/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GENERALITAT VALENCIANA//SEJI%2F2019%2F017//ACTIVA: ALTERACIONES DE LA CONSCIENCIA: PROTOCOLO/ es_ES
dc.rights.accessRights Abierto es_ES
dc.description.bibliographicCitation Noé Sebastián, E.; Ferri, J.; Olaya, J.; Navarro, MD.; O'valle, M.; Colomer Font, C.; Moliner, B.... (2021). When, How, and to What Extent Are Individuals with Unresponsive Wakefulness Syndrome Able to Progress? Neurobehavioral Progress. Brain Sciences. 11(1):1-16. https://doi.org/10.3390/brainsci11010126 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.3390/brainsci11010126 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 16 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 11 es_ES
dc.description.issue 1 es_ES
dc.identifier.eissn 2076-3425 es_ES
dc.identifier.pmid 33478033 es_ES
dc.identifier.pmcid PMC7835897 es_ES
dc.relation.pasarela S\438079 es_ES
dc.contributor.funder European Commission es_ES
dc.contributor.funder GENERALITAT VALENCIANA es_ES
dc.contributor.funder Universitat Politècnica de València es_ES


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