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dc.contributor.author | Llamas, Ernesto | es_ES |
dc.contributor.author | Torres-Montilla, Salvador | es_ES |
dc.contributor.author | Lee, Hyun Ju | es_ES |
dc.contributor.author | Barja, María Victoria | es_ES |
dc.contributor.author | Schlimgen, Elena | es_ES |
dc.contributor.author | Dunken, Nick | es_ES |
dc.contributor.author | Wagle, Prerana | es_ES |
dc.contributor.author | Werr, Wolfgang | es_ES |
dc.contributor.author | Zuccaro, Alga | es_ES |
dc.contributor.author | RODRIGUEZ CONCEPCIÓN, M. | es_ES |
dc.contributor.author | Vilchez, David | es_ES |
dc.date.accessioned | 2022-05-09T18:04:39Z | |
dc.date.available | 2022-05-09T18:04:39Z | |
dc.date.issued | 2021-08 | es_ES |
dc.identifier.issn | 1474-9718 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/182444 | |
dc.description.abstract | [EN] The biological purpose of plant stem cells is to maintain themselves while providing new pools of differentiated cells that form organs and rejuvenate or replace damaged tissues. Protein homeostasis or proteostasis is required for cell function and viability. However, the link between proteostasis and plant stem cell identity remains unknown. In contrast to their differentiated counterparts, we find that root stem cells can prevent the accumulation of aggregated proteins even under proteotoxic stress conditions such as heat stress or proteasome inhibition. Notably, root stem cells exhibit enhanced expression of distinct chaperones that maintain proteome integrity. Particularly, intrinsic high levels of the T-complex protein-1 ring complex/chaperonin containing TCP1 (TRiC/CCT) complex determine stem cell maintenance and their remarkable ability to suppress protein aggregation. Overexpression of CCT8, a key activator of TRiC/CCT assembly, is sufficient to ameliorate protein aggregation in differentiated cells and confer resistance to proteotoxic stress in plants. Taken together, our results indicate that enhanced proteostasis mechanisms in stem cells could be an important requirement for plants to persist under extreme environmental conditions and reach extreme long ages. Thus, proteostasis of stem cells can provide insights to design and breed plants tolerant to environmental challenges caused by the climate change. | es_ES |
dc.description.sponsorship | This work was supported by the European Research Council (ERC Starting Grant-677427 StemProteostasis) and the Deutsche Forschungsgemeinschaft (DFG) (Germany's Excellence Strategy CECAD, EXC 2030-390661388). This work was also supported by a Humboldt Research Fellowship for postdoctoral researchers to E. Llamas. Alga Zuccaro also thanks funding from the Deutsche Forschungsgemeinschaft (SFB-1403-414786233). | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | Blackwell Publishing | es_ES |
dc.relation.ispartof | Aging Cell | es_ES |
dc.rights | Reconocimiento (by) | es_ES |
dc.subject | Chaperones | es_ES |
dc.subject | Heat stress | es_ES |
dc.subject | Plant stem cells | es_ES |
dc.subject | Protein aggregation | es_ES |
dc.subject | Protein misfolding | es_ES |
dc.subject | Proteostasis | es_ES |
dc.title | The intrinsic chaperone network of Arabidopsis stem cells confers protection against proteotoxic stress | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1111/acel.13446 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/677427/EU | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/DFG//EXC 2030-390661388/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/DFG//SFB-1403 414786233/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes | es_ES |
dc.description.bibliographicCitation | Llamas, E.; Torres-Montilla, S.; Lee, HJ.; Barja, MV.; Schlimgen, E.; Dunken, N.; Wagle, P.... (2021). The intrinsic chaperone network of Arabidopsis stem cells confers protection against proteotoxic stress. Aging Cell. 20(8):1-26. https://doi.org/10.1111/acel.13446 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.1111/acel.13446 | es_ES |
dc.description.upvformatpinicio | 1 | es_ES |
dc.description.upvformatpfin | 26 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 20 | es_ES |
dc.description.issue | 8 | es_ES |
dc.identifier.pmid | 34327811 | es_ES |
dc.identifier.pmcid | PMC8373342 | es_ES |
dc.relation.pasarela | S\460361 | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.contributor.funder | Deutsche Forschungsgemeinschaft | es_ES |