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BIO bragg gratings on microfibers for label-free biosensing

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BIO bragg gratings on microfibers for label-free biosensing

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dc.contributor.author Juste-Dolz, Augusto Miguel es_ES
dc.contributor.author Delgado-Pinar, Martina es_ES
dc.contributor.author Avella-Oliver, Miquel es_ES
dc.contributor.author Fernández-Sánchez, María Estrella es_ES
dc.contributor.author Pastor Abellán, Daniel es_ES
dc.contributor.author Andrés, Miguel V. es_ES
dc.contributor.author Maquieira Catala, Ángel es_ES
dc.date.accessioned 2022-06-09T18:07:02Z
dc.date.available 2022-06-09T18:07:02Z
dc.date.issued 2021-03-15 es_ES
dc.identifier.issn 0956-5663 es_ES
dc.identifier.uri http://hdl.handle.net/10251/183163
dc.description.abstract [EN] Discovering nanoscale phenomena to sense biorecognition events introduces new perspectives to exploit nano science and nanotechnology for bioanalytical purposes. Here we present Bio Bragg Gratings (BBGs), a novel biosensing approach that consists of diffractive structures of protein bioreceptors patterned on the surface of optical waveguides, and tailored to transduce the magnitude of biorecognition assays into the intensity of single peaks in the reflection spectrum. This work addresses the design, fabrication, and optimization of this system by both theoretical and experimental studies to explore the fundamental physicochemical parameters involved. Functional biomolecular gratings are fabricated by microcontact printing on the surface of tapered optical microfibers, and their structural features were characterized. The transduction principle is experimentally demonstrated, and its quantitative bioanalytical prospects are assessed in a representative immunoassay, based on patterned protein probes and selective IgG targets, in label-free conditions. This biosensing system involves appealing perspectives to avoid unwanted signal contributions from non-specific binding, herein investigated in human serum samples. The work also proves how the optical response of the system can be easily tuned, and it provides insights into the relevance of this feature to conceive multiplexed BBG systems capable to perform multiple label-free biorecognition assays in a single device. es_ES
dc.description.sponsorship Spanish Ministry of Science and Innovation (CTQ2016-75749-R and TEC2016-80385-P), Agencia Estatal de Investigacion and Fondo Europeo de Desarrollo Regional (PID2019-110877 GB-I00 and PDI2019-104276RB-I00) and Generalitat Valenciana (PROMETEO/2019/048 and PROMETEO/2017/103). A.J.-D. acknowledges the FPI-UPV 2017 grant program, M.A.-O acknowledges the APSOSTD/2019 program of the GVA. es_ES
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof Biosensors and Bioelectronics es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Biosensor es_ES
dc.subject Diffraction es_ES
dc.subject Optical microfiber es_ES
dc.subject Immunoassay es_ES
dc.subject Non-specific binding es_ES
dc.subject Label-free es_ES
dc.subject.classification QUIMICA INORGANICA es_ES
dc.subject.classification QUIMICA ANALITICA es_ES
dc.subject.classification TEORIA DE LA SEÑAL Y COMUNICACIONES es_ES
dc.title BIO bragg gratings on microfibers for label-free biosensing es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.bios.2020.112916 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-104276RB-I00/ES/ONDAS ACUSTICAS EN FIBRAS OPTICAS Y MICROCAVIDADES/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEO%2F2019%2F048/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-110877GB-I00/ES/PLATAFORMA HIBRIDA DE NITRURO DE SILICIO PARA CIRCUITOS OPTICOS INTEGRATODS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//APOSTD%2F2019/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEO%2F2017%2F103//TECNOLOGIAS Y APLICACIONES FUTURAS DE LA FOTONICA DE MICROONDAS (FUTURE MWP TECHNOLOGIES & APPLICATIONS)/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/UPV//FPI 2017/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI//TEC2016-80385-P//SILICON NITRIDE SPECTROMETERS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI//CTQ2016-75749-R//BIOSENSORES HOLOGRAFICOS. PRUEBA DE CONCEPTO Y DEMOSTRACION EN APLICACIONES CLINICAS/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Comunicaciones - Departament de Comunicacions es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.description.bibliographicCitation Juste-Dolz, AM.; Delgado-Pinar, M.; Avella-Oliver, M.; Fernández-Sánchez, ME.; Pastor Abellán, D.; Andrés, MV.; Maquieira Catala, Á. (2021). BIO bragg gratings on microfibers for label-free biosensing. Biosensors and Bioelectronics. 176:1-8. https://doi.org/10.1016/j.bios.2020.112916 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1016/j.bios.2020.112916 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 8 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 176 es_ES
dc.identifier.pmid 33401145 es_ES
dc.relation.pasarela S\428544 es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder AGENCIA ESTATAL DE INVESTIGACION es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
dc.contributor.funder Universitat Politècnica de València es_ES


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