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What is the role of frequency on neural activation in tonic stimulation in SCS therapy? A computational study on sensoty Ab nerve fibers

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What is the role of frequency on neural activation in tonic stimulation in SCS therapy? A computational study on sensoty Ab nerve fibers

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dc.contributor.author Solanes, Carmen es_ES
dc.contributor.author Durá, José L. es_ES
dc.contributor.author De Andrés, Jose es_ES
dc.contributor.author Saiz Rodríguez, Francisco Javier es_ES
dc.date.accessioned 2022-06-28T18:08:06Z
dc.date.available 2022-06-28T18:08:06Z
dc.date.issued 2021 es_ES
dc.identifier.uri http://hdl.handle.net/10251/183674
dc.description.abstract [EN] The investigation of the effect of the stimulation parameters by computational modeling helps to understand the electrical response of specific neural elements in Spinal Cord Stimulation (SCS) therapy for chronic pain treatment. While the effect of the amplitude, the pulse width, and the electrode configuration on neural activation has been widely studied and is well-established in tonic stimulation, how frequency influences neural activation remains unclear. Thus, the aim of this work is to study the effect of frequency on the electrical response of sensory A beta neurons in tonic stimulation. Our approach consisted of the development of a new nerve fiber model from the combination of two previous models used in SCS modeling (the Wesselink-Holsheimer-Boom model and the Richardson-McIntyre-Grill model B). We simulate the action potential and the gates probabilities evolution of a 12.8 mu m fiber diameter at different pulse frequencies (50, 350, 600, 800, and 1000 Hz). We also simulated the firing rate of two nerve fiber diameters (5.7 and 12.8 mu m) in function of pulse frequency (from 1 to 1400 Hz) at different pulse widths (100, 300, and 500 mu s). In the range of 2-1000 Hz, the firing rate of a 12.8 mu m-diameter nerve fiber can be maximized by utilizing a 350 Hz, 300 mu s-stimulus. Frequencies above 350 Hz reduce half to one-third the firing rate, and 1000 Hz-stimulus overrides the electrical activity of the sensory nerve fiber. Small fibers (5.7 mu m-diameter) present lower firing rate values than large fibers (12.8 mu m-diameter). High values of pulse width decrease the firing rate of the nerve fibers as well as the range of frequencies that could be used to stimulate. According to the results, the frequency could have a considerable implication on the modulation of the firing rate of a nerve fiber. Thus, the frequency could play an important role to select and increase the activity of specific neural elements of the spinal cord in SCS therapy. es_ES
dc.language Inglés es_ES
dc.publisher Institute of Electrical and Electronics Engineers es_ES
dc.relation.ispartof IEEE Access es_ES
dc.rights Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) es_ES
dc.subject Ab nerve fibers es_ES
dc.subject Pulse frequency es_ES
dc.subject Sensory nerve fiber model es_ES
dc.subject Spinal cord stimulation therapy es_ES
dc.subject Tonic stimulation es_ES
dc.subject.classification TECNOLOGIA ELECTRONICA es_ES
dc.title What is the role of frequency on neural activation in tonic stimulation in SCS therapy? A computational study on sensoty Ab nerve fibers es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1109/ACCESS.2021.3099986 es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica es_ES
dc.description.bibliographicCitation Solanes, C.; Durá, JL.; De Andrés, J.; Saiz Rodríguez, FJ. (2021). What is the role of frequency on neural activation in tonic stimulation in SCS therapy? A computational study on sensoty Ab nerve fibers. IEEE Access. 9:107446-107461. https://doi.org/10.1109/ACCESS.2021.3099986 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1109/ACCESS.2021.3099986 es_ES
dc.description.upvformatpinicio 107446 es_ES
dc.description.upvformatpfin 107461 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 9 es_ES
dc.identifier.eissn 2169-3536 es_ES
dc.relation.pasarela S\455342 es_ES
upv.costeAPC 2200 es_ES


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