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Pharmaceutical characterization and pharmacokinetics of florfenicol-loaded alginate dried beads in rabbits

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Pharmaceutical characterization and pharmacokinetics of florfenicol-loaded alginate dried beads in rabbits

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dc.contributor.author Gutierrez Olvera, Lilia es_ES
dc.contributor.author Marcos Benitez, Xelhua es_ES
dc.contributor.author García-Guzmán, Perla es_ES
dc.contributor.author Monroy-Barreto, Minerva es_ES
dc.contributor.author Sumano, Héctor es_ES
dc.date.accessioned 2022-07-07T12:12:15Z
dc.date.available 2022-07-07T12:12:15Z
dc.date.issued 2022-06-29
dc.identifier.issn 1257-5011
dc.identifier.uri http://hdl.handle.net/10251/183941
dc.description.abstract [EN] The pharmacokinetic variables of a new formulation of florfenicol included in dried bean of alginate (FADBs), its acceptance as in food medication, and its relationship with theoretical minimum inhibitory concentration (MIC) values of the main pathogens in rabbits, are presented. FADBs sought to mask the unpleasant taste of florfenicol while enhancing sustained absorption in a day to facilitate and optimise its dosage in this species. The entrapment efficiency was determined to be 94-98% and 73.56±3.26% of drug loading. No reduction in food consumption was detected, nor selectivity when choosing from their usual food. The elimination half-life was 1.23 to 2.4 h slower than the one previously reported in the literature. Possible flip-flop pharmacokinetics is proposed for FADBs in rabbits, thus complying better with the key pharmacokinetics/pharmacodynamics (PK/PD) ratio of t?MIC. Also, if a MIC2.0 µg/mL is taken as the cut-off point for florfenicol in rabbits, then ad libitum intake of FADBs in their standard diet is sufficient to maintain plasma concentrations of florfenicol above this level during the whole dosing interval of 24 h. Additionally, FADBs are a low-cost and attractive drug delivery system for the oral controlled release of florfenicol in rabbits. es_ES
dc.description.sponsorship Posdoctoral and PAPIIT grant programs of the Universidad Nacional Autónoma de México es_ES
dc.language Inglés es_ES
dc.publisher Universitat Politècnica de València es_ES
dc.relation.ispartof World Rabbit Science es_ES
dc.rights Reconocimiento - No comercial - Compartir igual (by-nc-sa) es_ES
dc.subject Florfenicol es_ES
dc.subject Alginate es_ES
dc.subject Dried-beads es_ES
dc.subject Rabbits es_ES
dc.subject Pharmacokinetics es_ES
dc.title Pharmaceutical characterization and pharmacokinetics of florfenicol-loaded alginate dried beads in rabbits es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.4995/wrs.2022.16381
dc.rights.accessRights Abierto es_ES
dc.description.bibliographicCitation Gutierrez Olvera, L.; Marcos Benitez, X.; García-Guzmán, P.; Monroy-Barreto, M.; Sumano, H. (2022). Pharmaceutical characterization and pharmacokinetics of florfenicol-loaded alginate dried beads in rabbits. World Rabbit Science. 30(2):153-162. https://doi.org/10.4995/wrs.2022.16381 es_ES
dc.description.accrualMethod OJS es_ES
dc.relation.publisherversion https://doi.org/10.4995/wrs.2022.16381 es_ES
dc.description.upvformatpinicio 153 es_ES
dc.description.upvformatpfin 162 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 30 es_ES
dc.description.issue 2 es_ES
dc.identifier.eissn 1989-8886
dc.relation.pasarela OJS\16381 es_ES
dc.contributor.funder Universidad Nacional Autónoma de México es_ES
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