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Secreted Enzyme-Responsive System for Controlled Antifungal Agent Release

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Secreted Enzyme-Responsive System for Controlled Antifungal Agent Release

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dc.contributor.author Bernardos Bau, Andrea es_ES
dc.contributor.author Bozik, Matej es_ES
dc.contributor.author Montero, Ana es_ES
dc.contributor.author Pérez-Esteve, Édgar es_ES
dc.contributor.author García-Casado, Esther es_ES
dc.contributor.author Lhotka, Miroslav es_ES
dc.contributor.author Frankova, Adela es_ES
dc.contributor.author Marcos Martínez, María Dolores es_ES
dc.contributor.author Barat Baviera, José Manuel es_ES
dc.contributor.author Martínez-Máñez, Ramón es_ES
dc.contributor.author Kloucek, Pavel es_ES
dc.date.accessioned 2022-07-29T18:02:15Z
dc.date.available 2022-07-29T18:02:15Z
dc.date.issued 2021-05 es_ES
dc.identifier.uri http://hdl.handle.net/10251/184974
dc.description.abstract [EN] Essential oil components (EOCs) such as eugenol play a significant role in plant antimicrobial defense. Due to the volatility and general reactivity of these molecules, plants have evolved smart systems for their storage and release, which are key prerequisites for their efficient use. In this study, biomimetic systems for the controlled release of eugenol, inspired by natural plant defense mechanisms, were prepared and their antifungal activity is described. Delivery and antifungal studies of mesoporous silica nanoparticles (MSN) loaded with eugenol and capped with different saccharide gates-starch, maltodextrin, maltose and glucose-against fungus Aspergillus niger-were performed. The maltodextrin- and maltose-capped systems show very low eugenol release in the absence of the fungus Aspergillus niger but high cargo delivery in its presence. The anchored saccharides are degraded by exogenous enzymes, resulting in eugenol release and efficient inhibition of fungal growth. es_ES
dc.description.sponsorship This research was funded by the project NutRisk (Project No: CZ.02.1.01/0.0/0.0/16_019/0000845), the Spanish Government (projects RTI2018-100910-B-C41, RTI2018-101599-B-C22-AR and RTI2018-101599-B-C21-AR (MINECO/FEDER)) and the GeneralitatValenciana (project PROME-TEO 2018/024); by the National Agency for Agricultural Research of the Ministry of Agriculture of the Czech Republic under project Biostore QK21010064; and by the Research Infrastructure METROFOOD-CZ supported by the Ministry of Education, Youth, and Sports of the Czech Republic under project number LM201810. A.B. thanks the Spanish Government for financial support. es_ES
dc.language Inglés es_ES
dc.publisher MDPI AG es_ES
dc.relation.ispartof Nanomaterials es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Nanoparticles es_ES
dc.subject Essential oil component es_ES
dc.subject Antimicrobial es_ES
dc.subject Antifungal es_ES
dc.subject Exogenous enzyme es_ES
dc.subject Aspergillus niger es_ES
dc.subject.classification TECNOLOGIA DE ALIMENTOS es_ES
dc.subject.classification QUIMICA INORGANICA es_ES
dc.title Secreted Enzyme-Responsive System for Controlled Antifungal Agent Release es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.3390/nano11051280 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-100910-B-C41/ES/MATERIALES POROSOS INTELIGENTES MULTIFUNCIONALES Y DISPOSITIVOS ELECTRONICOS PARA LA LIBERACION DE FARMACOS, DETECCION DE DROGAS Y BIOMARCADORES Y COMUNICACION A NANOESCALA/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/CVUT//CZ.02.1.01%2F0.0%2F0.0%2F16_019%2F 0000845/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MZE//QK21010064//Biostore/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-101599-B-C21/ES/DESARROLLO Y APLICACION DE SISTEMAS ANTIMICROBIANOS PARA LA INDUSTRIA ALIMENTARIA BASADOS EN SUPERFICIES FUNCIONALIZADAS Y SISTEMAS DE LIBERACION CONTROLADA/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-101599-B-C22/ES/DESARROLLO Y APLICACION DE SISTEMAS ANTIMICROBIANOS PARA LA INDUSTRIA ALIMENTARIA BASADOS EN SUPERFICIES FUNCIONALIZADAS Y SISTEMAS DE LIBERACION CONTROLADA/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MEYS//LM201810/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEO%2F2018%2F024//Sistemas avanzados de liberación controlada/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Tecnología de Alimentos - Departament de Tecnologia d'Aliments es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.description.bibliographicCitation Bernardos Bau, A.; Bozik, M.; Montero, A.; Pérez-Esteve, É.; García-Casado, E.; Lhotka, M.; Frankova, A.... (2021). Secreted Enzyme-Responsive System for Controlled Antifungal Agent Release. Nanomaterials. 11(5):1-14. https://doi.org/10.3390/nano11051280 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.3390/nano11051280 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 14 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 11 es_ES
dc.description.issue 5 es_ES
dc.identifier.eissn 2079-4991 es_ES
dc.identifier.pmid 34068155 es_ES
dc.identifier.pmcid PMC8153022 es_ES
dc.relation.pasarela S\453008 es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Czech Technical University in Prague es_ES
dc.contributor.funder Ministry of Agriculture, República Checa es_ES
dc.contributor.funder Ministry of Education, Youth and Sport of the Czech Republic es_ES


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