- -

Early Embryo Exposure to Assisted Reproductive Manipulation Induced Subtle Changes in Liver Epigenetics with No Apparent Negative Health Consequences in Rabbit

RiuNet: Institutional repository of the Polithecnic University of Valencia

Share/Send to

Cited by

Statistics

  • Estadisticas de Uso

Early Embryo Exposure to Assisted Reproductive Manipulation Induced Subtle Changes in Liver Epigenetics with No Apparent Negative Health Consequences in Rabbit

Show simple item record

Files in this item

dc.contributor.author García-Domínguez, Ximo es_ES
dc.contributor.author Diretto, Gianfranco es_ES
dc.contributor.author Peñaranda, D.S. es_ES
dc.contributor.author Frusciante, Sarah es_ES
dc.contributor.author García-Carpintero, Víctor es_ES
dc.contributor.author Cañizares Sales, Joaquín es_ES
dc.contributor.author Vicente Antón, José Salvador es_ES
dc.contributor.author Marco-Jiménez, Francisco es_ES
dc.date.accessioned 2022-09-16T18:04:14Z
dc.date.available 2022-09-16T18:04:14Z
dc.date.issued 2021-09 es_ES
dc.identifier.uri http://hdl.handle.net/10251/186218
dc.description.abstract [EN] Embryo manipulation is a requisite step in assisted reproductive technology (ART). Therefore, it is of great necessity to appraise the safety of ART and investigate the long-term effect, including lipid metabolism, on ART-conceived offspring. Augmenting our ART rabbit model to investigate lipid metabolic outcomes in offspring longitudinally, we detected variations in hepatic DNA methylation ART offspring in the F3 generation for embryonic exposure (multiple ovulation, vitrification and embryo transfer). Through adult liver metabolomics and proteomics, we identified changes mainly related to lipid metabolism (e.g., polyunsaturated fatty acids, steroids, steroid hormone). We also found that DNA methylation analysis was linked to changes in lipid metabolism and apoptosis genes. Nevertheless, these differences did not apparently alter the general health status. Thus, our findings suggest that ART is likely to be a player in embryo epigenetic events related to hepatic homeostasis alteration in adulthood. es_ES
dc.description.sponsorship This research was funded by the Spanish Ministry of Economy and Competitiveness (MINECO), Spain, grant number AGL2014-53405-C2-1-P and by Conselleria d'Educacio, Investigacio, Cultura i Esport, Spain, grant number Prometeo II 2014/036. Ximo Garcia-Dominguez was supported by a research grant from the Ministry of Economy, Industry and Competitiveness of Spain (BES-2015-072429). es_ES
dc.language Inglés es_ES
dc.publisher MDPI AG es_ES
dc.relation.ispartof International Journal of Molecular Sciences es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Assisted reproductive technologies es_ES
dc.subject Vitrification es_ES
dc.subject Stress es_ES
dc.subject DNA methylation es_ES
dc.subject Metabolome es_ES
dc.subject Proteome es_ES
dc.subject Steroid biosynthesis es_ES
dc.subject.classification GENETICA es_ES
dc.subject.classification PRODUCCION ANIMAL es_ES
dc.subject.classification BIOLOGIA ANIMAL es_ES
dc.title Early Embryo Exposure to Assisted Reproductive Manipulation Induced Subtle Changes in Liver Epigenetics with No Apparent Negative Health Consequences in Rabbit es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.3390/ijms22189716 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//AGL2014-53405-C2-1-P/ES/MEJORA GENETICA DEL CONEJO DE CARNE:RESPUESTA A LA SELECCION Y SU EFECTO SOBRE LA REPRODUCCION, ALIMENTACION Y SALUD UTILIZANDO UNA POBLACION CONTROL CRIOCONSERVADA/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GENERALITAT VALENCIANA//PROMETEOII%2F2014%2F036//Crioconservación de óvulos y embriones. Cambios epigenéticos y repercusiones transcripcionales y proteómicas / es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//BES-2015-072429/ES/BES-2015-072429/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ciencia Animal - Departament de Ciència Animal es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Biotecnología - Departament de Biotecnologia es_ES
dc.description.bibliographicCitation García-Domínguez, X.; Diretto, G.; Peñaranda, D.; Frusciante, S.; García-Carpintero, V.; Cañizares Sales, J.; Vicente Antón, JS.... (2021). Early Embryo Exposure to Assisted Reproductive Manipulation Induced Subtle Changes in Liver Epigenetics with No Apparent Negative Health Consequences in Rabbit. International Journal of Molecular Sciences. 22(18):1-17. https://doi.org/10.3390/ijms22189716 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.3390/ijms22189716 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 17 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 22 es_ES
dc.description.issue 18 es_ES
dc.identifier.eissn 1422-0067 es_ES
dc.identifier.pmid 34575877 es_ES
dc.identifier.pmcid PMC8467347 es_ES
dc.relation.pasarela S\445836 es_ES
dc.contributor.funder GENERALITAT VALENCIANA es_ES
dc.contributor.funder MINISTERIO DE ECONOMIA Y EMPRESA es_ES
dc.contributor.funder Universitat Politècnica de València
upv.costeAPC 1800 es_ES


This item appears in the following Collection(s)

Show simple item record