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Comprehensive functional core microbiome comparison in genetically obese and lean hosts under the same environment

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Comprehensive functional core microbiome comparison in genetically obese and lean hosts under the same environment

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dc.contributor.author MARTINEZ ALVARO, MARINA es_ES
dc.contributor.author Zubiri-Gaitán, Agostina es_ES
dc.contributor.author Hernández, Pilar es_ES
dc.contributor.author Greenacre, Michael es_ES
dc.contributor.author Ferrer, Alberto es_ES
dc.contributor.author Blasco Mateu, Agustín es_ES
dc.date.accessioned 2022-09-28T18:03:32Z
dc.date.available 2022-09-28T18:03:32Z
dc.date.issued 2021-11-01 es_ES
dc.identifier.uri http://hdl.handle.net/10251/186683
dc.description.abstract [EN] Our study provides an exhaustive comparison of the microbiome core functionalities (captured by 3,936 microbial gene abundances) between hosts with divergent genotypes for intramuscular lipid deposition. After 10 generations of divergent selection for intramuscular fat in rabbits and 4.14 phenotypic standard deviations (SD) of selection response, we applied a combination of compositional and multivariate statistical techniques to identify 122 cecum microbial genes with differential abundances between the lines (ranging from ¿0.75 to +0.73¿SD). This work elucidates that microbial biosynthesis lipopolysaccharides, peptidoglycans, lipoproteins, mucin components, and NADH reductases, amongst others, are influenced by the host genetic determination for lipid accretion in muscle. We also differentiated between host-genetically influenced microbial mechanisms regulating lipid deposition in body or intramuscular reservoirs, with only 28 out of 122 MGs commonly contributing to both. Importantly, the results of this study are of relevant interest for the efficient development of strategies fighting obesity. es_ES
dc.description.sponsorship We acknowledge Prof. J.J. Egozcue and V. Pawlosky for their advice in the analysis of compositional data. This work was supported by project AGL2017-86083-C2-1-P from the Spanish National research plan. M. Martinez-alvaro acknowledges a post-doctoral grant (APOSTD/2017/060) from Generalitat Valenciana es_ES
dc.language Inglés es_ES
dc.publisher Springer Nature es_ES
dc.relation.ispartof Communications Biology es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject.classification ESTADISTICA E INVESTIGACION OPERATIVA es_ES
dc.subject.classification PRODUCCION ANIMAL es_ES
dc.title Comprehensive functional core microbiome comparison in genetically obese and lean hosts under the same environment es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1038/s42003-021-02784-w es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2017-86083-C2-1-P/ES/ESTUDIO MULTIOMICO SOBRE SENSIBILIDAD AMBIENTAL, LONGEVIDAD Y DEPOSICION GRASA EN LINEAS SELECCIONADAS DE CONEJO/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GENERALITAT VALENCIANA//APOSTD%2F2017%2F060//AYUDA POSTDOCTORAL GVA-MARTINEZ ALVARO PROYECTO: INTEGRACION DE LAS OMICAS EN ANIMALES DE GRANJA/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ciencia Animal - Departament de Ciència Animal es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Estadística e Investigación Operativa Aplicadas y Calidad - Departament d'Estadística i Investigació Operativa Aplicades i Qualitat es_ES
dc.description.bibliographicCitation Martinez Alvaro, M.; Zubiri-Gaitán, A.; Hernández, P.; Greenacre, M.; Ferrer, A.; Blasco Mateu, A. (2021). Comprehensive functional core microbiome comparison in genetically obese and lean hosts under the same environment. Communications Biology. 4:1-10. https://doi.org/10.1038/s42003-021-02784-w es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1038/s42003-021-02784-w es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 10 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 4 es_ES
dc.identifier.eissn 2399-3642 es_ES
dc.identifier.pmid 34725460 es_ES
dc.identifier.pmcid PMC8560826 es_ES
dc.relation.pasarela S\448858 es_ES
dc.contributor.funder GENERALITAT VALENCIANA es_ES
dc.contributor.funder AGENCIA ESTATAL DE INVESTIGACION es_ES
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