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Stability of Biomimetically Functionalised Alginate Microspheres as 3D Support in Cell Cultures

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Stability of Biomimetically Functionalised Alginate Microspheres as 3D Support in Cell Cultures

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dc.contributor.author García Briega, María Inmaculada es_ES
dc.contributor.author Ródenas Rochina, Joaquín es_ES
dc.contributor.author Ribeiro Martins, Luis Amaro es_ES
dc.contributor.author Gallego Ferrer, Gloria es_ES
dc.contributor.author Lanceros-Mendez, Senentxu es_ES
dc.contributor.author Sempere Talens, Amparo es_ES
dc.contributor.author Gómez Ribelles, José Luís es_ES
dc.date.accessioned 2022-10-11T10:55:47Z
dc.date.available 2022-10-11T10:55:47Z
dc.date.issued 2022-10-11
dc.identifier.uri http://hdl.handle.net/10251/187455
dc.description.abstract Alginate hydrogels can be used to develop a three-dimensional environment in which various cell types can be grown. Cross-linking the alginate chains using reversible ionic bonds opens up great possibilities for the encapsulation and subsequent release of cells or drugs. However, al-ginate also has a drawback in that its structure is not very stable in a culture medium with cellu-lar activity. This work explored the stability of alginate microspheres functionalised by grafting specific biomolecules onto their surface to form microgels in which biomimetic microspheres surrounded the cells in the culture, reproducing the natural microenvironment. A study was made of the stability of the microgel in different typical culture media and the formation of polyelectrolyte multilayers containing polylysine and heparin. Multiple myeloma cell prolifer-ation in the culture was tested in a bioreactor under gentle agitation. es_ES
dc.description.sponsorship The Microscopy Service of the UPV (Universitat Politècnica de València) is gratefully acknowl-edged for helping with cryoFESEM characterisation. CIBER-BBN is an initiative funded by the VI National R&D&I Plan 2008–2011, Iniciativa Ingenio 2010, Consolider Program. The Instituto de Salud Carlos III financed CIBER Actions with assistance from the European Regional Develop-ment Fund. es_ES
dc.language Inglés es_ES
dc.publisher MDPI es_ES
dc.publisher Universitat Politècnica de València es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Alginate es_ES
dc.subject Microspheres
dc.subject Stability
dc.subject Layer by layer
dc.subject Multiple myeloma
dc.subject.classification CIENCIA DE LOS MATERIALES E INGENIERIA METALURGICA es_ES
dc.title Stability of Biomimetically Functionalised Alginate Microspheres as 3D Support in Cell Cultures es_ES
dc.type Dataset es_ES
dc.identifier.doi 10.4995/Dataset/10251/187455 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-106099RB-C43/ES/DESARROLLO DE ANDAMIAJES BIOMIMETICOS ACTIVOS PARA EL ESTUDIO DE MICROENTORNO DE TUMOR EN OSTEOSARCOMA/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-106099RB-C41/ES/MICROGELES BIOMIMETICOS PARA EL ESTUDIO DE LA GENERACION DE RESISTENCIAS A FARMACOS EN EL MIELOMA MULTIPLE/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PRE2020-092326/Programa Estatal de Promoción del Talento y su Empleabilidad en I+D+i es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Centro de Biomateriales e Ingeniería Tisular es_ES
dc.description.bibliographicCitation García Briega, MI.; Ródenas Rochina, J.; Ribeiro Martins, LA.; Gallego Ferrer, G.; Lanceros-Mendez, S.; Sempere Talens, A.; Gómez Ribelles, JL. (2022). Stability of Biomimetically Functionalised Alginate Microspheres as 3D Support in Cell Cultures. MDPI. https://doi.org/10.4995/Dataset/10251/187455 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES


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