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dc.contributor.author | Moyano Rodríguez, Edelweiss![]() |
es_ES |
dc.contributor.author | Gomez-Mendoza, Miguel![]() |
es_ES |
dc.contributor.author | Pérez-Ruiz, Raúl![]() |
es_ES |
dc.contributor.author | Peñín, Beatriz![]() |
es_ES |
dc.contributor.author | Sampedro, Diego![]() |
es_ES |
dc.contributor.author | Caamaño, Antonio![]() |
es_ES |
dc.contributor.author | de la Peña O Shea, Víctor A.![]() |
es_ES |
dc.date.accessioned | 2022-11-07T19:01:56Z | |
dc.date.available | 2022-11-07T19:01:56Z | |
dc.date.issued | 2021-12 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/189396 | |
dc.description.abstract | [EN] Up-Conversion materials have received great attention in drug delivery applications in recent years. A specifically emerging field includes the development of strategies focusing on photon processes that promote the development of novel platforms for the efficient transport and the controlled release of drug molecules in the harsh microenvironment. Here, modified reaction time, thermal treatment, and pH conditions were controlled in the synthesis of NaYF4:Yb,Tm up-converted (UC) material to improve its photoluminescence properties. The best blue-emission performance was achieved for the UC3 sample prepared through 24 h-synthesis without thermal treatment at a pH of 5, which promotes the presence of the beta-phase and smaller particle size. NaYF4:Yb,Tm has resulted in a highly efficient blue emitter material for light-driven drug release under near-IR wavelength. Thus, NaYF4:Yb,Tm up-converted material promotes the N-O bond cleavage of the oxime ester of Ciprofloxacin (prodrug) as a highly efficient photosensitized drug delivery process. HPLC chromatography and transient absorption spectroscopy measurements were performed to evaluate the drug release conversion rate. UC3 has resulted in a very stable and easily recovered material that can be used in several reaction cycles. This straightforward methodology can be extended to other drugs containing photoactive chromophores and is present as an alternative for drug release systems. | es_ES |
dc.description.sponsorship | This research was funded by the European Union's Horizon 2020 research and innovation program under European Research Council (ERC) through the HyMAP project, grant agreement No. 648319. Financial support was received from AEI-MICINN/FEDER, UE through the Nympha Project (PID2019-106315RB-I00). R.P.-R. thanks to the Generalitat Valenciana for financial support (CIDEGENT/2018/044). | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | MDPI AG | es_ES |
dc.relation.ispartof | Biomedicines | es_ES |
dc.rights | Reconocimiento (by) | es_ES |
dc.subject | Up-Conversion | es_ES |
dc.subject | Drug-delivery | es_ES |
dc.subject | Near IR-Light Therapy | es_ES |
dc.title | Controlled Synthesis of Up-Conversion NaYF4:Yb,Tm Nanoparticles for Drug Release under Near IR-Light Therapy | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.3390/biomedicines9121953 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-106315RB-I00/ES/MATERIALES HIBRIDOS NANOESTRUCTURADOS PARA LA PRODUCCION FOTOELECTROCATALITICA DE COMBUSTIBLES SOLARES/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/GENERALITAT VALENCIANA//CIDEGENT%2F2018%2F044//PHOTON UPCONVERSION REDOX CATALYSIS/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/648319/EU | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.description.bibliographicCitation | Moyano Rodríguez, E.; Gomez-Mendoza, M.; Pérez-Ruiz, R.; Peñín, B.; Sampedro, D.; Caamaño, A.; De La Peña O Shea, VA. (2021). Controlled Synthesis of Up-Conversion NaYF4:Yb,Tm Nanoparticles for Drug Release under Near IR-Light Therapy. Biomedicines. 9(12):1-13. https://doi.org/10.3390/biomedicines9121953 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.3390/biomedicines9121953 | es_ES |
dc.description.upvformatpinicio | 1 | es_ES |
dc.description.upvformatpfin | 13 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 9 | es_ES |
dc.description.issue | 12 | es_ES |
dc.identifier.eissn | 2227-9059 | es_ES |
dc.identifier.pmid | 34944769 | es_ES |
dc.identifier.pmcid | PMC8699023 | es_ES |
dc.relation.pasarela | S\453080 | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.contributor.funder | GENERALITAT VALENCIANA | es_ES |
dc.contributor.funder | Agencia Estatal de Investigación | es_ES |
dc.contributor.funder | European Regional Development Fund | es_ES |