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Novel Tissue-Engineered Multimodular Hyaluronic Acid-Polylactic Acid Conduits for the Regeneration of Sciatic Nerve Defect

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Novel Tissue-Engineered Multimodular Hyaluronic Acid-Polylactic Acid Conduits for the Regeneration of Sciatic Nerve Defect

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dc.contributor.author Gisbert Roca, Fernando es_ES
dc.contributor.author Gil Santos, Luis es_ES
dc.contributor.author Mata Roig, Manuel es_ES
dc.contributor.author Milian Medina, Lara es_ES
dc.contributor.author Martínez-Ramos, Cristina es_ES
dc.contributor.author Monleón Pradas, Manuel es_ES
dc.date.accessioned 2023-04-21T18:01:32Z
dc.date.available 2023-04-21T18:01:32Z
dc.date.issued 2022-05 es_ES
dc.identifier.uri http://hdl.handle.net/10251/192910
dc.description.abstract [EN] The gold standard for the treatment of peripheral nerve injuries, the autograft, presents several drawbacks, and engineered constructs are currently suitable only for short gaps or small diameter nerves. Here, we study a novel tissue-engineered multimodular nerve guidance conduit for the treatment of large nerve damages based in a polylactic acid (PLA) microfibrillar structure inserted inside several co-linear hyaluronic acid (HA) conduits. The highly aligned PLA microfibers provide a topographical cue that guides axonal growth, and the HA conduits play the role of an epineurium and retain the pre-seeded auxiliary cells. The multimodular design increases the flexibility of the device. Its performance for the regeneration of a critical-size (15 mm) rabbit sciatic nerve defect was studied and, after six months, very good nerve regeneration was observed. The multimodular approach contributed to a better vascularization through the micrometrical gaps between HA conduits, and the pre-seeded Schwann cells increased axonal growth. Six months after surgery, a cross-sectional available area occupied by myelinated nerve fibers above 65% at the central and distal portions was obtained when the multimodular device with pre-seeded Schwann cells was employed. The results validate the multi-module approach for the regeneration of large nerve defects and open new possibilities for surgical solutions in this field. es_ES
dc.description.sponsorship This research was funded by the Spanish Government's State Research Agency (AEI) through projects DPI2015-72863-EXP and RTI2018-095872-B-C22/ERDF. Funding for open access charge: Universitat Politecnica de Valencia. es_ES
dc.language Inglés es_ES
dc.publisher MDPI AG es_ES
dc.relation.ispartof Biomedicines es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Nerve guidance conduit es_ES
dc.subject Hyaluronic acid es_ES
dc.subject Polylactic acid es_ES
dc.subject Aligned substrates es_ES
dc.subject Schwann cells es_ES
dc.subject Nerve regeneration es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title Novel Tissue-Engineered Multimodular Hyaluronic Acid-Polylactic Acid Conduits for the Regeneration of Sciatic Nerve Defect es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.3390/biomedicines10050963 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-095872-B-C22/ES/NUEVO DISPOSITIVO BIOACTIVO PARA LA REGENERACION DE LESIONES DE LA MEDULA ESPINAL/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MECD//FPU16%2F01833/ES/FPU16%2F01833/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//DPI2015-72863-EXP/ES/NEUROCABLES MODULARES: MULTIPLICANDO CONEXIONES NEURALES/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials es_ES
dc.description.bibliographicCitation Gisbert Roca, F.; Gil Santos, L.; Mata Roig, M.; Milian Medina, L.; Martínez-Ramos, C.; Monleón Pradas, M. (2022). Novel Tissue-Engineered Multimodular Hyaluronic Acid-Polylactic Acid Conduits for the Regeneration of Sciatic Nerve Defect. Biomedicines. 10(5):1-22. https://doi.org/10.3390/biomedicines10050963 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.3390/biomedicines10050963 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 22 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 10 es_ES
dc.description.issue 5 es_ES
dc.identifier.eissn 2227-9059 es_ES
dc.identifier.pmid 35625700 es_ES
dc.identifier.pmcid PMC9138968 es_ES
dc.relation.pasarela S\462065 es_ES
dc.contributor.funder MINISTERIO DE EDUCACION es_ES
dc.contributor.funder AGENCIA ESTATAL DE INVESTIGACION es_ES
dc.contributor.funder Universitat Politècnica de València es_ES
upv.costeAPC 2396 es_ES


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