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dc.contributor.author | Torres-Giner, Sergio | es_ES |
dc.contributor.author | Gimeno-Alcañiz, Jose V. | es_ES |
dc.contributor.author | Ocio, Maria J. | es_ES |
dc.contributor.author | Lagaron, Jose M. | es_ES |
dc.date.accessioned | 2023-04-25T18:01:30Z | |
dc.date.available | 2023-04-25T18:01:30Z | |
dc.date.issued | 2009-01-28 | es_ES |
dc.identifier.issn | 1944-8244 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/192952 | |
dc.description.abstract | [EN] Collagen, as the major structural protein of the extracellular matrix in animals, is a versatile biomaterial of great interest in various engineering applications. Electrospun nanofibers of collagen are regarded as very promising materials for tissue engineering applications because they can reproduce the morphology of the natural bone but have as a drawback a poor structural consistency in wet conditions. In this paper, a comparative study between the performance of different cross-linking methods such as a milder enzymatic treatment procedure using transglutaminase, the use of N-[3-(dimethylamino)propyl]-N¿-ethylcarbodiimide hydrochloride/ N-hydroxysuccinimide, and genipin, and the use of a physical method based on exposure to ultraviolet light was carried out. The chemical and enzymatic treatments provided, in this order, excellent consistency, morphology, cross-linking degree, and osteoblast viability for the collagen nanofibers. Interestingly, the enzymatically cross-linked collagen mats, which are considered to be a more biological treatment, promoted adequate cell adhesion, making the biomaterial biocompatible and with an adequate degree of porosity for cell seeding and in-growth. | es_ES |
dc.description.sponsorship | The authors acknowledge the EU integrated project NEWBONE, the company Nanobiomatters Ltd. (Paterna, Spain), and the Spanish MEC (Project MAT2006- 10261-C03) for financial support and Impex Química Corp. for supplying TG | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | American Chemical Society | es_ES |
dc.relation.ispartof | ACS Applied Materials & Interfaces | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | Nanofibers | es_ES |
dc.subject | Fibers | es_ES |
dc.subject | Biomaterials | es_ES |
dc.subject | Biopolymers | es_ES |
dc.subject | Nucleic acid structure | es_ES |
dc.title | Comparative Performance of Electrospun Collagen Nanofibers Cross-linked by Means of Different Methods | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1021/am800063x | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MEC//MAT2006-10261-C03-03/ES/EVALUACION Y OPTIMIZACION DE LA ACTIVIDAD ANTIMICROBIANA DE NANOBIOCOMPUESTOS PARA SU APLICACION EN ENVASES ACTIVOS ALIMENTARIOS/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MEC//TEC2007-30328-E/ES/NEWBONE: SOLICITUD DE PROYECTO INTEGRADO AL FP7/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Instituto Universitario de Ingeniería de Alimentos para el Desarrollo - Institut Universitari d'Enginyeria d'Aliments per al Desenvolupament | es_ES |
dc.description.bibliographicCitation | Torres-Giner, S.; Gimeno-Alcañiz, JV.; Ocio, MJ.; Lagaron, JM. (2009). Comparative Performance of Electrospun Collagen Nanofibers Cross-linked by Means of Different Methods. ACS Applied Materials & Interfaces. 1(1):218-223. https://doi.org/10.1021/am800063x | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.1021/am800063x | es_ES |
dc.description.upvformatpinicio | 218 | es_ES |
dc.description.upvformatpfin | 223 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 1 | es_ES |
dc.description.issue | 1 | es_ES |
dc.identifier.pmid | 20355775 | es_ES |
dc.relation.pasarela | S\427580 | es_ES |
dc.contributor.funder | Nanobiomatters, Ltd. | es_ES |
dc.contributor.funder | Ministerio de Educación y Ciencia | es_ES |