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pH-Dependent Molecular Gate Mesoporous Microparticles for Biological Control of Giardia intestinalis

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pH-Dependent Molecular Gate Mesoporous Microparticles for Biological Control of Giardia intestinalis

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dc.contributor.author Gonzalez-Alvarez, Isabel es_ES
dc.contributor.author Vivancos, Verónica es_ES
dc.contributor.author Coll Merino, Mª Carmen es_ES
dc.contributor.author Sánchez-Dengra, B. es_ES
dc.contributor.author Aznar, Elena es_ES
dc.contributor.author Ruiz Picazo, Alejandro es_ES
dc.contributor.author Bermejo, Marival es_ES
dc.contributor.author Sancenón Galarza, Félix es_ES
dc.contributor.author Dea-Ayuela, M. Auxiliadora es_ES
dc.contributor.author Gonzalez -Alvarez, Marta es_ES
dc.contributor.author Martínez-Máñez, Ramón es_ES
dc.date.accessioned 2023-04-26T18:01:25Z
dc.date.available 2023-04-26T18:01:25Z
dc.date.issued 2021-01 es_ES
dc.identifier.uri http://hdl.handle.net/10251/192983
dc.description.abstract [EN] Giardiasis is a parasitism produced by the protozoa Giardia intestinalis that lives as trophozoite in the small intestine (mainly in the duodenum) attached to the intestinal villus by means of billed discs. The first line treatment is metronidazole, a drug with high bioavailability, which is why to obtain therapeutic concentrations in duodenum, it is necessary to administer high doses of drug to patients with the consequent occurrence of side effects. It is necessary to developed new therapeutical approaches to achieve a local delivery of the drug. In this sense, we have developed gated mesoporous silica microparticles loaded with metronidazole and with a molecular gate pH dependent. In vitro assays demonstrated that the metronidazole release is practically insignificant at acidic pHs, but in duodenum conditions, the metronidazole delivery from the microparticles is effective enough to produce an important parasite destruction. In vivo assays indicate that this microparticulate system allows to increase the concentration of the drug in duodenum and reduce the concentration in plasma avoiding systemic effects. This system could be useful for other intestinal local treatments in order to reduce doses and increase drug availability in target tissues. es_ES
dc.description.sponsorship M.G.-A., I.G.-A. and M.B. thank the financial support from the project "MODELOS IN VITRO DE EVALUACION BIOFARMACEUTICA" SAF2016-78756(AEI/FEDER, EU) funded by Agencia Estatal Investigacion and European Union, through FEDER (Fondo Europeo de Desarrollo Regional). The authors thank the financial support from the Spanish Government (projects RTI2018-100910-B-C41 and RTI2018-101599-B-C22-AR (MCUI/FEDER, EU)), Generalitat Valenciana (project PROMETEO 2018/024) and Universitat Politecnica de Valencia-FISABIO (project A41METRO-RELEASE). The authors also thank the Electron Microscopy Service at the UPV for support. B.S.-D. received a grant from the Ministry of Science, Innovation and Universities of Spain, grant number FPU17/00530. es_ES
dc.language Inglés es_ES
dc.publisher MDPI AG es_ES
dc.relation.ispartof Pharmaceutics es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Mesoporous microparticles es_ES
dc.subject G. intestinalis es_ES
dc.subject Molecular gate es_ES
dc.subject Targeted drug delivery es_ES
dc.subject Oral administration es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.subject.classification QUIMICA INORGANICA es_ES
dc.title pH-Dependent Molecular Gate Mesoporous Microparticles for Biological Control of Giardia intestinalis es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.3390/pharmaceutics13010094 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-100910-B-C41/ES/MATERIALES POROSOS INTELIGENTES MULTIFUNCIONALES Y DISPOSITIVOS ELECTRONICOS PARA LA LIBERACION DE FARMACOS, DETECCION DE DROGAS Y BIOMARCADORES Y COMUNICACION A NANOESCALA/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GENERALITAT VALENCIANA//PROMETEO%2F2018%2F024//SISTEMAS AVANZADOS DE LIBERACION CONTROLADA/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-101599-B-C22/ES/DESARROLLO Y APLICACION DE SISTEMAS ANTIMICROBIANOS PARA LA INDUSTRIA ALIMENTARIA BASADOS EN SUPERFICIES FUNCIONALIZADAS Y SISTEMAS DE LIBERACION CONTROLADA/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEO%2F2018%2F024//Sistemas avanzados de liberación controlada/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MCIU//FPU17%2F00530/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//SAF2016-78756/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/FISABIO//A41//METRO-RELEASE/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería del Diseño - Escola Tècnica Superior d'Enginyeria del Disseny es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials es_ES
dc.description.bibliographicCitation Gonzalez-Alvarez, I.; Vivancos, V.; Coll Merino, MC.; Sánchez-Dengra, B.; Aznar, E.; Ruiz Picazo, A.; Bermejo, M.... (2021). pH-Dependent Molecular Gate Mesoporous Microparticles for Biological Control of Giardia intestinalis. Pharmaceutics. 13(1):1-17. https://doi.org/10.3390/pharmaceutics13010094 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.3390/pharmaceutics13010094 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 17 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 13 es_ES
dc.description.issue 1 es_ES
dc.identifier.eissn 1999-4923 es_ES
dc.identifier.pmid 33451061 es_ES
dc.identifier.pmcid PMC7828499 es_ES
dc.relation.pasarela S\430984 es_ES
dc.contributor.funder GENERALITAT VALENCIANA es_ES
dc.contributor.funder AGENCIA ESTATAL DE INVESTIGACION es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Universitat Politècnica de València es_ES
dc.contributor.funder Ministerio de Ciencia, Innovación y Universidades es_ES
dc.contributor.funder Ministerio de Economía, Industria y Competitividad es_ES
dc.contributor.funder Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana es_ES


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