dc.contributor.author |
García-Briega, María Inmaculada
|
es_ES |
dc.contributor.author |
Ródenas Rochina, Joaquín
|
es_ES |
dc.contributor.author |
Ribeiro-Martins, Luis Amaro
|
es_ES |
dc.contributor.author |
Lanceros-Méndez, Senentxu
|
es_ES |
dc.contributor.author |
Gallego-Ferrer, Gloria
|
es_ES |
dc.contributor.author |
Sempere, Amparo
|
es_ES |
dc.contributor.author |
Gómez Ribelles, José Luís
|
es_ES |
dc.date.accessioned |
2023-05-08T18:02:16Z |
|
dc.date.available |
2023-05-08T18:02:16Z |
|
dc.date.issued |
2022-10 |
es_ES |
dc.identifier.uri |
http://hdl.handle.net/10251/193223 |
|
dc.description.abstract |
[EN] Alginate hydrogels can be used to develop a three-dimensional environment in which various cell types can be grown. Cross-linking the alginate chains using reversible ionic bonds opens up great possibilities for the encapsulation and subsequent release of cells or drugs. However, alginate also has a drawback in that its structure is not very stable in a culture medium with cellular activity. This work explored the stability of alginate microspheres functionalised by grafting specific biomolecules onto their surface to form microgels in which biomimetic microspheres surrounded the cells in the culture, reproducing the natural microenvironment. A study was made of the stability of the microgel in different typical culture media and the formation of polyelectrolyte multilayers containing polylysine and heparin. Multiple myeloma cell proliferation in the culture was tested in a bioreactor under gentle agitation. |
es_ES |
dc.description.sponsorship |
This work was funded by the Spanish State Research Agency (AEI) through the PID2019-106099RB-C41/AEI/10.13039/501100011033 and PID2019-106099RB-C43/AEI/10.13039/501100011033 Projects. This work was also supported by the Spanish Ministry of Science, Innovation and Universities through Grant No PRE2020-092326 awarded to Ma Inmaculada Garcia-Briega. Funding from the Basque Government Industry Departments under the ELKARTEK program is also acknowledged. |
es_ES |
dc.language |
Inglés |
es_ES |
dc.publisher |
MDPI AG |
es_ES |
dc.relation.ispartof |
Polymers |
es_ES |
dc.rights |
Reconocimiento (by) |
es_ES |
dc.subject |
Alginate |
es_ES |
dc.subject |
Microspheres |
es_ES |
dc.subject |
Stability |
es_ES |
dc.subject |
Layer by layer |
es_ES |
dc.subject |
Multiple myeloma |
es_ES |
dc.subject.classification |
MAQUINAS Y MOTORES TERMICOS |
es_ES |
dc.title |
Stability of Biomimetically Functionalised Alginate Microspheres as 3D Support in Cell Cultures |
es_ES |
dc.type |
Artículo |
es_ES |
dc.identifier.doi |
10.3390/POLYM14204282 |
es_ES |
dc.relation.projectID |
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-106099RB-C41/ES/MICROGELES BIOMIMETICOS PARA EL ESTUDIO DE LA GENERACION DE RESISTENCIAS A FARMACOS EN EL MIELOMA MULTIPLE/ |
es_ES |
dc.relation.projectID |
info:eu-repo/grantAgreement/AEI//PRE2020-092326//MICROGELES BIOMIMETICOS PARA EL ESTUDIO DE LA GENERACION DE RESISTENCIAS A FARMACOS EN EL MIELOMA MULTIPLE/ |
es_ES |
dc.relation.projectID |
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-106099RB-C43/ES/DESARROLLO DE ANDAMIAJES BIOMIMETICOS ACTIVOS PARA EL ESTUDIO DE MICROENTORNO DE TUMOR EN OSTEOSARCOMA/ |
es_ES |
dc.rights.accessRights |
Abierto |
es_ES |
dc.contributor.affiliation |
Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials |
es_ES |
dc.description.bibliographicCitation |
García-Briega, MI.; Ródenas Rochina, J.; Ribeiro-Martins, LA.; Lanceros-Méndez, S.; Gallego-Ferrer, G.; Sempere, A.; Gómez Ribelles, JL. (2022). Stability of Biomimetically Functionalised Alginate Microspheres as 3D Support in Cell Cultures. Polymers. 14(20):1-17. https://doi.org/10.3390/POLYM14204282 |
es_ES |
dc.description.accrualMethod |
S |
es_ES |
dc.relation.publisherversion |
https://doi.org/10.3390/POLYM14204282 |
es_ES |
dc.description.upvformatpinicio |
1 |
es_ES |
dc.description.upvformatpfin |
17 |
es_ES |
dc.type.version |
info:eu-repo/semantics/publishedVersion |
es_ES |
dc.description.volume |
14 |
es_ES |
dc.description.issue |
20 |
es_ES |
dc.identifier.eissn |
2073-4360 |
es_ES |
dc.identifier.pmid |
36297867 |
es_ES |
dc.identifier.pmcid |
PMC9611185 |
es_ES |
dc.relation.pasarela |
S\473857 |
es_ES |
dc.contributor.funder |
Eusko Jaurlaritza |
es_ES |
dc.contributor.funder |
AGENCIA ESTATAL DE INVESTIGACION |
es_ES |
dc.contributor.funder |
Agencia Estatal de Investigación |
es_ES |