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Stability of Biomimetically Functionalised Alginate Microspheres as 3D Support in Cell Cultures

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Stability of Biomimetically Functionalised Alginate Microspheres as 3D Support in Cell Cultures

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dc.contributor.author García-Briega, María Inmaculada es_ES
dc.contributor.author Ródenas Rochina, Joaquín es_ES
dc.contributor.author Ribeiro-Martins, Luis Amaro es_ES
dc.contributor.author Lanceros-Méndez, Senentxu es_ES
dc.contributor.author Gallego-Ferrer, Gloria es_ES
dc.contributor.author Sempere, Amparo es_ES
dc.contributor.author Gómez Ribelles, José Luís es_ES
dc.date.accessioned 2023-05-08T18:02:16Z
dc.date.available 2023-05-08T18:02:16Z
dc.date.issued 2022-10 es_ES
dc.identifier.uri http://hdl.handle.net/10251/193223
dc.description.abstract [EN] Alginate hydrogels can be used to develop a three-dimensional environment in which various cell types can be grown. Cross-linking the alginate chains using reversible ionic bonds opens up great possibilities for the encapsulation and subsequent release of cells or drugs. However, alginate also has a drawback in that its structure is not very stable in a culture medium with cellular activity. This work explored the stability of alginate microspheres functionalised by grafting specific biomolecules onto their surface to form microgels in which biomimetic microspheres surrounded the cells in the culture, reproducing the natural microenvironment. A study was made of the stability of the microgel in different typical culture media and the formation of polyelectrolyte multilayers containing polylysine and heparin. Multiple myeloma cell proliferation in the culture was tested in a bioreactor under gentle agitation. es_ES
dc.description.sponsorship This work was funded by the Spanish State Research Agency (AEI) through the PID2019-106099RB-C41/AEI/10.13039/501100011033 and PID2019-106099RB-C43/AEI/10.13039/501100011033 Projects. This work was also supported by the Spanish Ministry of Science, Innovation and Universities through Grant No PRE2020-092326 awarded to Ma Inmaculada Garcia-Briega. Funding from the Basque Government Industry Departments under the ELKARTEK program is also acknowledged. es_ES
dc.language Inglés es_ES
dc.publisher MDPI AG es_ES
dc.relation.ispartof Polymers es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Alginate es_ES
dc.subject Microspheres es_ES
dc.subject Stability es_ES
dc.subject Layer by layer es_ES
dc.subject Multiple myeloma es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title Stability of Biomimetically Functionalised Alginate Microspheres as 3D Support in Cell Cultures es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.3390/POLYM14204282 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-106099RB-C41/ES/MICROGELES BIOMIMETICOS PARA EL ESTUDIO DE LA GENERACION DE RESISTENCIAS A FARMACOS EN EL MIELOMA MULTIPLE/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI//PRE2020-092326//MICROGELES BIOMIMETICOS PARA EL ESTUDIO DE LA GENERACION DE RESISTENCIAS A FARMACOS EN EL MIELOMA MULTIPLE/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-106099RB-C43/ES/DESARROLLO DE ANDAMIAJES BIOMIMETICOS ACTIVOS PARA EL ESTUDIO DE MICROENTORNO DE TUMOR EN OSTEOSARCOMA/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials es_ES
dc.description.bibliographicCitation García-Briega, MI.; Ródenas Rochina, J.; Ribeiro-Martins, LA.; Lanceros-Méndez, S.; Gallego-Ferrer, G.; Sempere, A.; Gómez Ribelles, JL. (2022). Stability of Biomimetically Functionalised Alginate Microspheres as 3D Support in Cell Cultures. Polymers. 14(20):1-17. https://doi.org/10.3390/POLYM14204282 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.3390/POLYM14204282 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 17 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 14 es_ES
dc.description.issue 20 es_ES
dc.identifier.eissn 2073-4360 es_ES
dc.identifier.pmid 36297867 es_ES
dc.identifier.pmcid PMC9611185 es_ES
dc.relation.pasarela S\473857 es_ES
dc.contributor.funder Eusko Jaurlaritza es_ES
dc.contributor.funder AGENCIA ESTATAL DE INVESTIGACION es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES


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