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Senescence and the Impact on Biodistribution of Different Nanosystems: the Discrepancy on Tissue Deposition of Graphene Quantum Dots, Polycaprolactone Nanoparticle and Magnetic Mesoporous Silica Nanoparticles in Young and Elder Animals

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Senescence and the Impact on Biodistribution of Different Nanosystems: the Discrepancy on Tissue Deposition of Graphene Quantum Dots, Polycaprolactone Nanoparticle and Magnetic Mesoporous Silica Nanoparticles in Young and Elder Animals

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dc.contributor.author Rezende dos Reis, Sara Rhaissa es_ES
dc.contributor.author Rocha Pinto, Suyene es_ES
dc.contributor.author Duarte de Menezes, Frederico es_ES
dc.contributor.author Martínez-Máñez, Ramón es_ES
dc.contributor.author Ricci-Junior, Eduardo es_ES
dc.contributor.author Rebelo Alencar, Luciana Magalhaes es_ES
dc.contributor.author Helal-Neto, Edward es_ES
dc.contributor.author Da Silva De Barros, Aline Oliveira es_ES
dc.contributor.author Lisboa, Patricia Cristina es_ES
dc.contributor.author Santos-Oliveira, Ralph es_ES
dc.date.accessioned 2023-05-29T18:02:30Z
dc.date.available 2023-05-29T18:02:30Z
dc.date.issued 2020-01-22 es_ES
dc.identifier.issn 0724-8741 es_ES
dc.identifier.uri http://hdl.handle.net/10251/193703
dc.description.abstract [EN] Purposes Senescence is an inevitable and irreversible process, which may lead to loss in muscle and bone density, decline in brain volume and loss in renal clearance. Although aging is a well-known process, few studies on the consumption of nanodrugs by elderly people were performed. Methods We evaluated three different nanosystems: i) carbon based nanosystem (Graphene Quantum Dots, GQD), ii) polymeric nanoparticles and mesoporous silica (magnetic core mesoporous silica, MMSN). In previous studies, our group has already characterized GQD and MMSN nanoparticles by dynamic light scattering analysis, atomic force microscopy, transmission electron microscopy, X-ray diffraction, Raman analysis, fluorescence and absorbance. The polymeric nanoparticle has been characterized by AFM and DLS. All the nanosystems were radiolabeled with 99 m-Tc by. The in vivo biodistribution/tissue deposition analysis evaluation was done using elder (PN270) and young (PN90) mice injected with radioactive nanosystems. Results The nanosystems used in this study were well-formed as the radiolabeling processes were stable. Biodistribution analysis showed that there is a decrease in the uptake of the nanoparticles in elder mice when compared to young mice, showing that is necessary to increase the initial dose in elder people to achieve the same concentration when compared to young animals. Conclusion The discrepancy on tissue distribution of nanosystems between young and elder individuals must be monitored, as the therapeutic effect will be different in the groups. Noteworthy, this data is an alarm that some specific conditions must be evaluated before commercialization of nano-drugs. Changes between younger and elderly individuals are undoubtedly, especially in drug tissue deposition, biodistribution and pharmacokinetics. The same thought should be applied to nanoparticles. A comprehensive analysis on how age discrepancy change the biological behavior of nanoparticles has been performed. es_ES
dc.language Inglés es_ES
dc.publisher Springer-Verlag es_ES
dc.relation.ispartof Pharmaceutical Research es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Elderly es_ES
dc.subject Graphene es_ES
dc.subject Mesoporous slica es_ES
dc.subject Biodistribution es_ES
dc.subject Nanomaterial es_ES
dc.subject Youth es_ES
dc.subject.classification QUIMICA INORGANICA es_ES
dc.title Senescence and the Impact on Biodistribution of Different Nanosystems: the Discrepancy on Tissue Deposition of Graphene Quantum Dots, Polycaprolactone Nanoparticle and Magnetic Mesoporous Silica Nanoparticles in Young and Elder Animals es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1007/s11095-019-2754-9 es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials es_ES
dc.description.bibliographicCitation Rezende Dos Reis, SR.; Rocha Pinto, S.; Duarte De Menezes, F.; Martínez-Máñez, R.; Ricci-Junior, E.; Rebelo Alencar, LM.; Helal-Neto, E.... (2020). Senescence and the Impact on Biodistribution of Different Nanosystems: the Discrepancy on Tissue Deposition of Graphene Quantum Dots, Polycaprolactone Nanoparticle and Magnetic Mesoporous Silica Nanoparticles in Young and Elder Animals. Pharmaceutical Research. 37(3):1-12. https://doi.org/10.1007/s11095-019-2754-9 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1007/s11095-019-2754-9 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 12 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 37 es_ES
dc.description.issue 3 es_ES
dc.identifier.pmid 31970499 es_ES
dc.relation.pasarela S\418251 es_ES
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