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Enhanced Antibacterial Activity through Silver Nanoparticles Deposited onto Carboxylated Graphene Oxide Surface

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Enhanced Antibacterial Activity through Silver Nanoparticles Deposited onto Carboxylated Graphene Oxide Surface

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dc.contributor.author Barjola, Arturo es_ES
dc.contributor.author Tormo-Mas, María Ángeles es_ES
dc.contributor.author Sahuquillo, Oscar es_ES
dc.contributor.author Bernabé-Quispe, Patricia es_ES
dc.contributor.author Pérez, José Manuel es_ES
dc.contributor.author Giménez Torres, Enrique es_ES
dc.date.accessioned 2023-06-20T18:01:19Z
dc.date.available 2023-06-20T18:01:19Z
dc.date.issued 2022-06 es_ES
dc.identifier.uri http://hdl.handle.net/10251/194409
dc.description.abstract [EN] The strong bactericidal action of silver nanoparticles (AgNPs) is usually limited by their degree of aggregation. Deposition of AgNPs onto a graphene oxide (GO) surface to generate GO-Ag hybrids has been shown to be an effective method of controlling these aggregation problems. In this sense, a novel carboxylated graphene oxide-silver nanoparticle (GOCOOH-Ag) material has been synthesized, and their antibacterial and biofilm formation inhibitions have been studied. AgNPs decorating the GOCOOH surface achieved an average size of 6.74 +/- 0.25 nm, which was smaller than that of AgNPs deposited onto the GO surface. In addition, better distribution of AgNPs was achieved using carboxylated material. It is important to highlight the main role of the carboxylic groups in the nucleation and growth of the AgNPs that decorate the GO-based material surface. In vitro antibacterial activity and antibiofilm-forming action were tested against Gram-positive (Staphylococcus aureus and Staphylococcus epidermidis) and Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli). Both GO-Ag and GOCOOH-Ag reduced bacterial growth, analyzed by time-kill curves. However, the minimum inhibitory concentration and the minimum bactericidal concentration of GOCOOH-Ag were lower than those of GO-Ag for all strains studied, indicating that GOCOOH-Ag has better antibacterial activity. In addition, both nanomaterials prevent biofilm formation, with a higher reduction of biofilm mass and cell viability in the presence of GOCOOH-Ag. The carboxylation functionalization in GO-based materials can be applied to improve the bactericidal and antibiofilm-forming action of the AgNPs. es_ES
dc.description.sponsorship This research was funded by Agencia Valenciana de la Innovacio (Valencian Regional Government) under the project INNEST00/19/002 and the Spanish Ministerio de Economia, Industria y Competitividad (project SAF2017-82251-R) and co-financed with ERDF (European Regional Development Fund) "A way for Europe". es_ES
dc.language Inglés es_ES
dc.publisher MDPI AG es_ES
dc.relation.ispartof Nanomaterials es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Carboxylated graphene oxide es_ES
dc.subject Antimicrobial es_ES
dc.subject Biocide es_ES
dc.subject Silver nanoparticles es_ES
dc.subject.classification CIENCIA DE LOS MATERIALES E INGENIERIA METALURGICA es_ES
dc.title Enhanced Antibacterial Activity through Silver Nanoparticles Deposited onto Carboxylated Graphene Oxide Surface es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.3390/nano12121949 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-82251-R/ES/NUEVAS ESTRATEGIAS DE PREVENCION Y DIAGNOSTICO DE LAS INFECCIONES RELACIONADAS CON DISPOSITIVOS BIOMEDICOS CAUSADOS POR STAPHYLOCOCCUS SPP/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AGENCIA VALENCIANA DE LA INNOVACION//INNEST00%2F19%2F002//PREVENCIÓN DE INFECCIONES RELACIONADAS CON LA ASISTENCIA SANITARIA MEDIANTE LA IMPLEMENTACIÓN DE SISTEMAS BIOCIDAS MULTIFUNCIONALES BASADOS EN MATERIALES NANOESTRUCTURADOS MOF Y GRAFENOS/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Tecnología de Materiales - Institut de Tecnologia de Materials es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería del Diseño - Escola Tècnica Superior d'Enginyeria del Disseny es_ES
dc.description.bibliographicCitation Barjola, A.; Tormo-Mas, MÁ.; Sahuquillo, O.; Bernabé-Quispe, P.; Pérez, JM.; Giménez Torres, E. (2022). Enhanced Antibacterial Activity through Silver Nanoparticles Deposited onto Carboxylated Graphene Oxide Surface. Nanomaterials. 12(12):1-15. https://doi.org/10.3390/nano12121949 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.3390/nano12121949 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 15 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 12 es_ES
dc.description.issue 12 es_ES
dc.identifier.eissn 2079-4991 es_ES
dc.identifier.pmid 35745288 es_ES
dc.identifier.pmcid PMC9228250 es_ES
dc.relation.pasarela S\467679 es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder AGENCIA VALENCIANA DE LA INNOVACION es_ES
dc.contributor.funder Universitat Politècnica de València es_ES
upv.costeAPC 2542,8 es_ES


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