Abouassali, O.; Chang, M.; Chidipi, B.; Martínez-De-Juan, JL.; Reiser, M.; Kanithi, M.; Soni, R.... (2020). In vitro and in vivo cardiac toxicity of flavored electronic nicotine delivery systems. AJP Heart and Circulatory Physiology. 320(1):H133-H143. https://doi.org/10.1152/ajpheart.00283.2020
Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/194763
Título:
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In vitro and in vivo cardiac toxicity of flavored electronic nicotine delivery systems
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Autor:
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Abouassali, Obada
Chang, Mengmeng
Chidipi, Bojjibabu
Martínez-de-Juan, José L.
Reiser, Michelle
Kanithi, Manasa
Soni, Ravi
McDonald, Thomas V.
Herweg, Bengt
Saiz Rodríguez, Francisco Javier
Calcul, Laurent
Noujaim, Sami F.
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Entidad UPV:
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Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials
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Fecha difusión:
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Resumen:
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[EN] The usage of flavored electronic nicotine delivery systems (ENDS) is popular, specifically in the teen and young adult age-groups. The possible cardiac toxicity of the flavoring aspect of ENDS is largely unknown. ...[+]
[EN] The usage of flavored electronic nicotine delivery systems (ENDS) is popular, specifically in the teen and young adult age-groups. The possible cardiac toxicity of the flavoring aspect of ENDS is largely unknown. Vaping, a form of electronic nicotine delivery, uses ¿e-liquid¿ to generate ¿e-vapor,¿ an aerosolized mixture of nicotine and/or flavors. We report our investigation into the cardiotoxic effects of flavored e-liquids. E-vapors containing flavoring aldehydes such as vanillin and cinnamaldehyde, as indicated by mass spectrometry, were more toxic in HL-1 cardiomyocytes than fruit-flavored e-vapor. Exposure of human induced pluripotent stem cell-derived cardiomyocytes to cinnamaldehyde or vanillin-flavored e-vapor affected the beating frequency and prolonged the field potential duration of these cells more than fruit-flavored e-vapor. In addition, vanillin aldehyde-flavored e-vapor reduced the human ether-à-go-go-related gene (hERG)-encoded potassium current in transfected human embryonic kidney cells. In mice, inhalation exposure to vanillin aldehyde-flavored e-vapor for 10¿wk caused increased sympathetic predominance in heart rate variability measurements. In vivo inducible ventricular tachycardia was significantly longer, and in optical mapping, the magnitude of ventricular action potential duration alternans was significantly larger in the vanillin aldehyde-flavored e-vapor-exposed mice than in controls. We conclude that the widely popular flavored ENDS are not harm free, and they have a potential for cardiac harm. More studies are needed to further assess their cardiac safety profile and long-term health effects.
NEW & NOTEWORTHY The use of electronic nicotine delivery systems (ENDS) is not harm free. It is not known whether ENDS negatively affect cardiac electrophysiological function. Our study in cell lines and in mice shows that ENDS can compromise cardiac electrophysiology, leading to action potential instability and inducible ventricular arrhythmias. Further investigations are necessary to assess the long-term cardiac safety profile of ENDS products in humans and to better understand how individual components of ENDS affect cardiac toxicity.
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Palabras clave:
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Arrhythmias
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Cardiac electrophysiology
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Electronic cigarettes
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ENDS
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Vaping
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Derechos de uso:
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Reserva de todos los derechos
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Fuente:
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AJP Heart and Circulatory Physiology. (issn:
0363-6135
)
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DOI:
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10.1152/ajpheart.00283.2020
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Editorial:
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American Physiological Society
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Versión del editor:
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https://doi.org/10.1152/ajpheart.00283.2020
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Código del Proyecto:
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info:eu-repo/grantAgreement/NIH//R21HL138064/
info:eu-repo/grantAgreement/NIH//R01HL129136/
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Agradecimientos:
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This work was supported in part by National Heart, Lung, and Blood Institute Grants R21HL138064 and R01HL129136 (to S. F. Noujaim) and American Heart Association postdoctoral fellowship (to B. Chidipi).
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Tipo:
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Artículo
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