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Adult Neural Stem Cell Migration Is Impaired in a Mouse Model of Alzheimer's Disease

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Adult Neural Stem Cell Migration Is Impaired in a Mouse Model of Alzheimer's Disease

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dc.contributor.author Esteve, Daniel es_ES
dc.contributor.author Molina-Navarro, María Micaela es_ES
dc.contributor.author Giraldo-Reboloso, Esther es_ES
dc.contributor.author Martínez-Varea, Noelia es_ES
dc.contributor.author Blanco-Gandia, Mari Carmen es_ES
dc.contributor.author Rodríguez-Arias, Marta es_ES
dc.contributor.author García-Verdugo, Jose Manuel es_ES
dc.contributor.author Viña, José es_ES
dc.contributor.author Lloret, Ana es_ES
dc.date.accessioned 2023-07-26T18:02:18Z
dc.date.available 2023-07-26T18:02:18Z
dc.date.issued 2022-02 es_ES
dc.identifier.issn 0893-7648 es_ES
dc.identifier.uri http://hdl.handle.net/10251/195605
dc.description.abstract [EN] Neurogenesis in the adult brain takes place in two neurogenic niches: the ventricular-subventricular zone (V-SVZ) and the subgranular zone. After differentiation, neural precursor cells (neuroblasts) have to move to an adequate position, a process known as neuronal migration. Some studies show that in Alzheimer's disease, the adult neurogenesis is impaired. Our main aim was to investigate some proteins involved both in the physiopathology of Alzheimer's disease and in the neuronal migration process using the APP/PS1 Alzheimer's mouse model. Progenitor migrating cells are accumulated in the V-SVZ of the APP/PS1 mice. Furthermore, we find an increase of Cdh1 levels and a decrease of Cdk5/p35 and cyclin B1, indicating that these cells have an alteration of the cell cycle, which triggers a senescence state. We find less cells in the rostral migratory stream and less mature neurons in the olfactory bulbs from APP/PS1 mice, leading to an impaired odour discriminatory ability compared with WT mice. Alzheimer's disease mice present a deficit in cell migration from V-SVZ due to a senescent phenotype. Therefore, these results can contribute to a new approach of Alzheimer's based on senolytic compounds or pro-neurogenic factors. es_ES
dc.description.sponsorship Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This work was supported by the following grants: Instituto de Salud Carlos III CB16/10/00435 (CIBER-FES), (PID2019-110906RB-I00/AEI/10.13039/501100011033) from the Spanish Ministry of Innovation and Science, PROMETEO/2019/097 from `Conselleria, de Sanitat de la Generalitat Valenciana' and EU Funded H2020-DIABFRAIL-LATAM (Ref: 825546), European Joint Programming Initiative `A Healthy Diet for a Healthy Life' (JPI HDHL) and of the ERA-NET Cofound ERA-HDHL (GA No 696295 of the EU Horizon 2020 Research and Innovation Programme). Part of the equipment employed in this work has been funded by Generalitat Valenciana and co-financed with ERDF funds (OP ERDF of Comunitat Valenciana 2014-2020). Special Research Actions from University of Valencia (REF: UV-INV-AE-1546096). es_ES
dc.language Inglés es_ES
dc.publisher Springer-Verlag es_ES
dc.relation.ispartof Molecular Neurobiology es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Subventricular zone es_ES
dc.subject Beta-amyloid toxicity es_ES
dc.subject Neurogenesis es_ES
dc.subject Senescence es_ES
dc.subject Olfaction es_ES
dc.subject.classification BIOLOGIA CELULAR es_ES
dc.title Adult Neural Stem Cell Migration Is Impaired in a Mouse Model of Alzheimer's Disease es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1007/s12035-021-02620-6 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-110906RB-I00/ES/NUEVAS INTERVENCIONES TERAPEUTICAS MULTIDOMINIO PARA RETRASAR LA FRAGILIDAD Y LA DISCAPACIDAD. IDENTIFICACION DE MECANISMOS MOLECULARES CON RELEVANCIA TRASLACIONAL/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEO%2F2019%2F097/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/696295/EU es_ES
dc.relation.projectID info:eu-repo/grantAgreement/ISCIII//CB16%2F10%2F00435//CIBER-FES/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/825546/EU es_ES
dc.relation.projectID info:eu-repo/grantAgreement/UV//UV-INV-AE-1546096/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural - Escola Tècnica Superior d'Enginyeria Agronòmica i del Medi Natural es_ES
dc.description.bibliographicCitation Esteve, D.; Molina-Navarro, MM.; Giraldo-Reboloso, E.; Martínez-Varea, N.; Blanco-Gandia, MC.; Rodríguez-Arias, M.; García-Verdugo, JM.... (2022). Adult Neural Stem Cell Migration Is Impaired in a Mouse Model of Alzheimer's Disease. Molecular Neurobiology. 59(2):1168-1182. https://doi.org/10.1007/s12035-021-02620-6 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1007/s12035-021-02620-6 es_ES
dc.description.upvformatpinicio 1168 es_ES
dc.description.upvformatpfin 1182 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 59 es_ES
dc.description.issue 2 es_ES
dc.identifier.pmid 34894324 es_ES
dc.identifier.pmcid PMC8857127 es_ES
dc.relation.pasarela S\458322 es_ES
dc.contributor.funder European Commission es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Universitat de València es_ES
dc.contributor.funder Instituto de Salud Carlos III es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
dc.contributor.funder European Regional Development Fund es_ES
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