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dc.contributor.author | Garcia-Dominguez, Ximo![]() |
es_ES |
dc.contributor.author | Vera Donoso, César D.![]() |
es_ES |
dc.contributor.author | Lopez-Moncholi, Eric![]() |
es_ES |
dc.contributor.author | Moreno-Manzano, Victoria![]() |
es_ES |
dc.contributor.author | Vicente Antón, José Salvador![]() |
es_ES |
dc.contributor.author | Marco-Jiménez, Francisco![]() |
es_ES |
dc.date.accessioned | 2023-09-12T18:04:00Z | |
dc.date.available | 2023-09-12T18:04:00Z | |
dc.date.issued | 2022-06 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/196272 | |
dc.description.abstract | [EN] In order to harness the potential of metanephroi allotransplantation to the generation of a functional kidney graft on demand, we must achieve further growth post-transplantation. Sildenafil citrate (SC) is widely known as a useful inductor of angiogenesis, offering renoprotective properties due to its anti-inflammatory, antifibrotic, and antiapoptotic effects. Here, we performed a laparoscopic metanephroi allotransplantation after embedding sildenafil citrate into the retroperitoneal fat of non-immunosuppressed adult rabbit hosts. Histology and histomorphometry were used to examine the morphofunctional changes in new kidneys 21 days post-transplantation. Immunofluorescence of E-cadherin and renin and erythropoietin gene expression were used to assess the tubule integrity and endocrine functionality. After the metanephroi were embedded in a 10 mu M SC solution, the new kidneys' weights become increased significantly. The E-cadherin expression together with the renin and erythropoietin gene expression revealed its functionality, while histological mature glomeruli and hydronephrosis proved the new kidneys' excretory function. Thus, we have described a procedure through the use of SC that improves the outcomes after a metanephroi transplantation. This study gives hope to a pathway that could offer a handsome opportunity to overcome the kidney shortage. | es_ES |
dc.description.sponsorship | This research was funded by Alcer-turia foundation, Astellas pharma inc., and Precipita crowdfunding. X.G.-D. was supported by a research grant from the Ministry of Economy, Industry and Competitiveness of Spain (BES-2015-072429). | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | MDPI AG | es_ES |
dc.relation.ispartof | Journal of Clinical Medicine | es_ES |
dc.rights | Reconocimiento (by) | es_ES |
dc.subject | Kidney | es_ES |
dc.subject | Metanephros | es_ES |
dc.subject | Organogenesis | es_ES |
dc.subject | Transplantation | es_ES |
dc.subject | Regenerative medicine | es_ES |
dc.subject.classification | PRODUCCION ANIMAL | es_ES |
dc.title | Sildenafil Citrate Enhances Renal Organogenesis Following Metanephroi Allotransplantation into Non-Immunosuppressed Hosts | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.3390/jcm11113068 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//BES-2015-072429/ES/BES-2015-072429/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural - Escola Tècnica Superior d'Enginyeria Agronòmica i del Medi Natural | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Instituto de Instrumentación para Imagen Molecular - Institut d'Instrumentació per a Imatge Molecular | es_ES |
dc.description.bibliographicCitation | Garcia-Dominguez, X.; Vera Donoso, CD.; Lopez-Moncholi, E.; Moreno-Manzano, V.; Vicente Antón, JS.; Marco-Jiménez, F. (2022). Sildenafil Citrate Enhances Renal Organogenesis Following Metanephroi Allotransplantation into Non-Immunosuppressed Hosts. Journal of Clinical Medicine. 11(11):1-13. https://doi.org/10.3390/jcm11113068 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.3390/jcm11113068 | es_ES |
dc.description.upvformatpinicio | 1 | es_ES |
dc.description.upvformatpfin | 13 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 11 | es_ES |
dc.description.issue | 11 | es_ES |
dc.identifier.eissn | 2077-0383 | es_ES |
dc.relation.pasarela | S\467777 | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad | es_ES |
dc.contributor.funder | ASOC PARA LUCHA CONTRA ENFERMEDADES DEL RIÑON - ALCER-TURIA | es_ES |
dc.contributor.funder | Asociación para la lucha contra las enfermedades del riñón | es_ES |
dc.contributor.funder | Universitat Politècnica de València | es_ES |
upv.costeAPC | 2100 | es_ES |