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In vivo toxicity assessment of eugenol and vanillin-functionalised silica particles using Caenorhabditis elegans

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In vivo toxicity assessment of eugenol and vanillin-functionalised silica particles using Caenorhabditis elegans

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dc.contributor.author Fuentes López, Cristina es_ES
dc.contributor.author VERDÚ AMAT, SAMUEL es_ES
dc.contributor.author Fuentes López, Ana es_ES
dc.contributor.author Ruiz, María José es_ES
dc.contributor.author Barat Baviera, José Manuel es_ES
dc.date.accessioned 2023-09-15T18:01:13Z
dc.date.available 2023-09-15T18:01:13Z
dc.date.issued 2022-06-15 es_ES
dc.identifier.issn 0147-6513 es_ES
dc.identifier.uri http://hdl.handle.net/10251/196625
dc.description.abstract [EN] The toxicological properties of different silica particles functionalised with essential oil components (EOCs) were herein assessed using the in vivo model C. elegans. In particular, the effects of the acute and long-term exposure to three silica particle types (SAS, MCM-41 micro, MCM-41 nano), either bare or functionalised with eugenol or vanillin, were evaluated on different biological parameters of nematodes. Acute exposure to the different particles did not reduce nematodes survival, brood growth or locomotion, but reproduction was impaired by all the materials, except for vanillin-functionalised MCM-41 nano. Moreover, long-term exposure to particles led to strongly inhibited nematodes growth and reproduction. The eugenol-functionalised particles exhibited higher functionalisation yields and had the strongest effects during acute and long-term exposures. Overall, the vanillin-functionalised particles displayed milder acute toxic effects on reproduction than pristine materials, but severer toxicological responses for the 96-hour exposure assays. Our findings suggest that the EOC type anchored to silica surfaces and functionalisation yield are crucial for determining the toxicological effects of particles on C. elegans. The results obtained with this alternative in vivo model can help to anticipate potential toxic responses to these new materials for human health and the environment. es_ES
dc.description.sponsorship The authors are grateful to the Spanish Government (Project RTI2018-101599-B-C21 (MCUI/AEI/FEDER, EU)) and the Generalitat Valenciana (grant agreement no. ACIF/2016/139) for financial support. The authors appreciate the supporting help in providing nematodes from the Caenorhabditis elegans Center (CGC), which is funded by the NIH Office of Research Infrastructure Programs (P40 OD010440). Funding for open access charge: Universitat Politécnica de Valéncia. es_ES
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof Ecotoxicology and Environmental Safety es_ES
dc.rights Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) es_ES
dc.subject Silicon dioxide es_ES
dc.subject Functionalisation es_ES
dc.subject Nematode es_ES
dc.subject Essential oil components es_ES
dc.subject Oral exposure es_ES
dc.subject.classification TECNOLOGIA DE ALIMENTOS es_ES
dc.title In vivo toxicity assessment of eugenol and vanillin-functionalised silica particles using Caenorhabditis elegans es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.ecoenv.2022.113601 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI//RTI2018-101599-B-C21-AR//DESARROLLO Y APLICACION DE SISTEMAS ANTIMICROBIANOS PARA LA INDUSTRIA ALIMENTARIA BASADOS EN SUPERFICIES FUNCIONALIZADAS Y SISTEMAS DE LIBERACION CONTROLADA/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GENERALITAT VALENCIANA//ACIF%2F2016%2F139//AYUDA CONSELLERIA PARA LA CONTRATACION DE PERSONAL INVESTIGADOR PREDOCTORAL-FUENTES LOPEZ (EVALUACION DE TOXICIDAD DE SOPORTES BIOCOMPATIBLES)/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/NIH//P40 OD010440/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Tecnología de Alimentos - Departament de Tecnologia d'Aliments es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural - Escola Tècnica Superior d'Enginyeria Agronòmica i del Medi Natural es_ES
dc.description.bibliographicCitation Fuentes López, C.; Verdú Amat, S.; Fuentes López, A.; Ruiz, MJ.; Barat Baviera, JM. (2022). In vivo toxicity assessment of eugenol and vanillin-functionalised silica particles using Caenorhabditis elegans. Ecotoxicology and Environmental Safety. 238:1-11. https://doi.org/10.1016/j.ecoenv.2022.113601 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1016/j.ecoenv.2022.113601 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 11 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 238 es_ES
dc.identifier.pmid 35533449 es_ES
dc.relation.pasarela S\464899 es_ES
dc.contributor.funder GENERALITAT VALENCIANA es_ES
dc.contributor.funder Caenorhabditis Genetics Center es_ES
dc.contributor.funder AGENCIA ESTATAL DE INVESTIGACION es_ES
dc.contributor.funder National Institutes of Health, EEUU es_ES
dc.contributor.funder Universitat Politècnica de València es_ES
upv.costeAPC 2485 es_ES


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