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Osteogenic differentiation of human mesenchymal stem cells on substituted calcium phosphate/chitosan composite scaffold

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Osteogenic differentiation of human mesenchymal stem cells on substituted calcium phosphate/chitosan composite scaffold

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dc.contributor.author Ressler, A. es_ES
dc.contributor.author Antunovic, Maja es_ES
dc.contributor.author Teruel Biosca, Laura es_ES
dc.contributor.author Gallego-Ferrer, Gloria es_ES
dc.contributor.author Babic, Slaven es_ES
dc.contributor.author Urlic, Inga es_ES
dc.contributor.author Ivankovic, Marica es_ES
dc.contributor.author Ivankovic, Hrvoje es_ES
dc.date.accessioned 2023-09-26T18:00:44Z
dc.date.available 2023-09-26T18:00:44Z
dc.date.issued 2022-02-01 es_ES
dc.identifier.issn 0144-8617 es_ES
dc.identifier.uri http://hdl.handle.net/10251/197136
dc.description.abstract [EN] Ionic substitutions are a promising strategy to enhance the biological performance of calcium phosphates (CaP) and composite materials for bone tissue engineering applications. However, systematic studies have not been performed on multi-substituted organic/inorganic scaffolds. In this work, highly porous composite scaffolds based on CaPs substituted with Sr2+, Mg2+, Zn2+ and SeO3 2¿ ions, and chitosan have been prepared by freezegelation technique. The scaffolds have shown highly porous structure, with very well interconnected pores and homogeneously dispersed CaPs, and high stability during 28 days in the degradation medium. Osteogenic potential of human mesenchymal stem cells seeded on scaffolds has been determined by histological, immunohistochemical and RT-qPCR analysis of cultured cells in static and dynamic conditions. Results indicated that ionic substitutions have a beneficial effect on cells and tissues. The scaffolds with multi-substituted CaPs have shown increased expression of osteogenesis related markers and increased phosphate deposits, compared to the scaffolds with non-substituted CaPs. es_ES
dc.description.sponsorship The financial supports of the European Regional Development Fund (grant KK.01.1.1.07.0014) , the PID2019-106000RB-C21/AEI/10.13039/501100011033 project from the Spanish Research Agency, and the L'Oreal-UNESCO "For Women in Science" Foundation are gratefully acknowledged. es_ES
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof Carbohydrate Polymers es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Chitosan es_ES
dc.subject Hydroxyapatite es_ES
dc.subject Osteogenic differentiation es_ES
dc.subject Perfusion-bioreactor es_ES
dc.subject Scaffolds es_ES
dc.subject Ionic substitution es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title Osteogenic differentiation of human mesenchymal stem cells on substituted calcium phosphate/chitosan composite scaffold es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.carbpol.2021.118883 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-106000RB-C21/ES/HIDROGELES BIOMIMETICOS IMPRIMIBLES CON PRESENTACION DE FACTORES DE CRECIMIENTO EFICIENTE PARA ESTUDIOS DE HEPATOTOXICIDAD DE ALTO RENDIMIENTO/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/ESIF//KK.01.1.1.07.0014/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials es_ES
dc.description.bibliographicCitation Ressler, A.; Antunovic, M.; Teruel Biosca, L.; Gallego-Ferrer, G.; Babic, S.; Urlic, I.; Ivankovic, M.... (2022). Osteogenic differentiation of human mesenchymal stem cells on substituted calcium phosphate/chitosan composite scaffold. Carbohydrate Polymers. 277:1-16. https://doi.org/10.1016/j.carbpol.2021.118883 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https:doi.org/10.1016/j.carbpol.2021.118883 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 16 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 277 es_ES
dc.relation.pasarela S\486629 es_ES
dc.contributor.funder L'Oréal es_ES
dc.contributor.funder AGENCIA ESTATAL DE INVESTIGACION es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder European Structural and Investment Funds es_ES


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