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dc.contributor.author | Hurtado, Alejandro![]() |
es_ES |
dc.contributor.author | Cano-Vicent, Alba![]() |
es_ES |
dc.contributor.author | Tuñón-Molina, Alberto![]() |
es_ES |
dc.contributor.author | Aparicio-Collado, José Luís![]() |
es_ES |
dc.contributor.author | Sabater i Serra, Roser![]() |
es_ES |
dc.contributor.author | Salesa, Beatriz![]() |
es_ES |
dc.contributor.author | Serrano-Aroca, Ángel![]() |
es_ES |
dc.date.accessioned | 2023-09-27T18:01:43Z | |
dc.date.available | 2023-09-27T18:01:43Z | |
dc.date.issued | 2022-10-31 | es_ES |
dc.identifier.issn | 0141-8130 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/197245 | |
dc.description.abstract | [EN] A new biodegradable semi-interpenetrated polymer network (semi-IPN) of two US Food and Drug Administration approved materials, poly(3-hydroxybutyrate-co-3-valerate) (PHBV) and calcium alginate (CA) was engineered to provide an alternative strategy to enhance the poor adhesion properties of CA. The synthesis procedure allows the additional incorporation of 10 % w/w of graphene nanoplatelets (GNPs), which have no cytotoxic effect on human keratinocytes. This quantity of multilayer graphene provides superior antiviral activity to the novel semi-IPN against a surrogate virus of SARS-CoV-2. Adding GNPs hardly affects the water absorption or electrical conductivity of the pure components of CA and PHBV. However, the semi-IPN's electrical conductivity increases dramatically after adding GNP due to molecular rearrangements of the intertwined polymer chains that continuously distribute the GNP nanosheets, This new hydrophilic composite biomaterial film shows great promise for skin biomedical applications, especially those that require antiviral and/or biodegradable electro-conductive materials. | es_ES |
dc.description.sponsorship | This research was funded by the Fundacion Universidad Catolica de Valencia San Vicente Martir, Grant 2020-231-006UCV, the Spanish Ministry of Science and Innovation (PID2020-119333RB-I00/AEI/10.13039/501100011033) (awarded to ?A.S-A) , and the FEDER/Spanish Ministry of Science and Innovation-Agencia Estatal de Investigacion through the Project RTI2018-097862-B-C21 (awarded to R.S.i.S) . CIBER-BBN is an initiative funded by the VI National R & D & I Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program. CIBER Ac-tions are financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation.ispartof | International Journal of Biological Macromolecules | es_ES |
dc.rights | Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) | es_ES |
dc.subject | PHBV | es_ES |
dc.subject | Alginate | es_ES |
dc.subject | Graphene nanoplatelets | es_ES |
dc.subject.classification | INGENIERIA ELECTRICA | es_ES |
dc.title | Engineering alginate hydrogel films with poly (3-hydroxybutyrate-co-3-valerate) and graphene nanoplatelets: Enhancement of antiviral activity, cell adhesion and electroactive properties | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1016/j.ijbiomac.2022.08.039 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-119333RB-I00/ES/SOPORTES BIOFUNCIONALES CON CAPACIDAD OSTEOINDUCTORA Y ANTIMICROBIANA PARA INGENIERIA TISULAR OSEA/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/UCV//2020-231-006UCV/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-097862-B-C21/ES/MICROENTORNOS BIOACTIVOS, ELECTROCONDUCTIVOS Y ANTIMICROBIANOS CON CAPACIDAD DE ESTIMULAR LA REGENERACION OSEA Y PREVENIR INFECCIONES MULTIRRESISTENTES/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería del Diseño - Escola Tècnica Superior d'Enginyeria del Disseny | es_ES |
dc.description.bibliographicCitation | Hurtado, A.; Cano-Vicent, A.; Tuñón-Molina, A.; Aparicio-Collado, JL.; Sabater I Serra, R.; Salesa, B.; Serrano-Aroca, Á. (2022). Engineering alginate hydrogel films with poly (3-hydroxybutyrate-co-3-valerate) and graphene nanoplatelets: Enhancement of antiviral activity, cell adhesion and electroactive properties. International Journal of Biological Macromolecules. 219:694-708. https://doi.org/10.1016/j.ijbiomac.2022.08.039 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.ijbiomac.2022.08.039 | es_ES |
dc.description.upvformatpinicio | 694 | es_ES |
dc.description.upvformatpfin | 708 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 219 | es_ES |
dc.identifier.pmid | 35961550 | es_ES |
dc.identifier.pmcid | PMC9364692 | es_ES |
dc.relation.pasarela | S\470662 | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | AGENCIA ESTATAL DE INVESTIGACION | es_ES |
dc.contributor.funder | Agencia Estatal de Investigación | es_ES |
dc.contributor.funder | European Regional Development Fund | es_ES |
dc.contributor.funder | Universidad Católica de Valencia San Vicente Mártir | es_ES |