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Pterin lysine photoadduct: a potential candidate for photoallergy

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Pterin lysine photoadduct: a potential candidate for photoallergy

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dc.contributor.author Farías, Jesuan J. es_ES
dc.contributor.author Lizondo-Aranda, Paloma es_ES
dc.contributor.author Thomas, Andrés H. es_ES
dc.contributor.author Lhiaubet, Virginie Lyria es_ES
dc.contributor.author Dántola, M. Laura es_ES
dc.date.accessioned 2023-10-19T18:01:29Z
dc.date.available 2023-10-19T18:01:29Z
dc.date.issued 2022-09 es_ES
dc.identifier.issn 1474-905X es_ES
dc.identifier.uri http://hdl.handle.net/10251/198409
dc.description.abstract [EN] Photoallergy is a photosensitivity disorder associated with a modified ability of the skin to react to the combined effect of drugs and sunlight. It has been attributed to the covalent conjugation of proteins with a photosensitizer, yielding modified macromolecules that can act as antigen provoking the immune system response. The potential role of some endogenous compounds as photoallergens has not been fully established. It has been previously proposed that pterins, which are endogenous photosensitizers present in human skin under pathological conditions, are able to covalently bind to proteins. Here, we evaluated the capability of pterin (Ptr) to form photoadducts with free Lysine (Lys) and poly-L-lysine (poly-Lys). The findings obtained using chromatographic and spectroscopic tools, confirm the formation of photoadducts of Ptr with Lys residues. With poly-Lys the resulting adduct retains the spectroscopic properties of the photosensitizer, suggesting that the aromatic Ptr structure is conserved. On the other hand, the photoproduct formed with free Lys does not behave like Ptr, which suggests that if this product is a photoadduct, a chemical modification may have occurred during the photochemical reaction that alters the pterin moiety. es_ES
dc.description.sponsorship Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. es_ES
dc.language Inglés
dc.publisher The Royal Society of Chemistry es_ES
dc.relation.ispartof Photochemical & Photobiological Sciences es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Pterin es_ES
dc.subject Lysine es_ES
dc.subject Poly-lysine es_ES
dc.subject Photobinding es_ES
dc.subject Photoallergy es_ES
dc.subject UV-A radiation es_ES
dc.title Pterin lysine photoadduct: a potential candidate for photoallergy es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1007/s43630-022-00248-6 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PGC2018-096684-B-I00/ES/REPARACION DEL ADN POR PROCESOS MULTIFOTONICOS/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Tecnología Química - Institut Universitari Mixt de Tecnologia Química es_ES
dc.description.bibliographicCitation Farías, JJ.; Lizondo-Aranda, P.; Thomas, AH.; Lhiaubet, VL.; Dántola, ML. (2022). Pterin lysine photoadduct: a potential candidate for photoallergy. Photochemical & Photobiological Sciences. 21(9):1647-1657. https://doi.org/10.1007/s43630-022-00248-6 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1007/s43630-022-00248-6 es_ES
dc.description.upvformatpinicio 1647 es_ES
dc.description.upvformatpfin 1657 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 21 es_ES
dc.description.issue 9 es_ES
dc.identifier.pmid 35666464 es_ES
dc.relation.pasarela S\485660 es_ES
dc.contributor.funder Ministerio de Ciencia, Innovación y Universidades es_ES
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