Mayol, B.; Diez-Sánchez, P.; Sánchez, A.; De La Torre, C.; Villalonga, A.; Lucena-Sánchez, E.; Sancenón Galarza, F.... (2021). A glutathione disulfide-sensitive Janus nanomachine controlled by an enzymatic AND logic gate for smart delivery. Nanoscale. 13(44):18616-18625. https://doi.org/10.1039/d0nr08282a
Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/199500
Title:
|
A glutathione disulfide-sensitive Janus nanomachine controlled by an enzymatic AND logic gate for smart delivery
|
Author:
|
Mayol, Beatriz
Diez-Sánchez, Paula
Sánchez, Alfredo
De La Torre, Cristina
Villalonga, Anabel
Lucena-Sánchez, Elena
Sancenón Galarza, Félix
Martinez-Ruiz, Paloma
Vilela, Diana
Martínez-Máñez, Ramón
Villalonga, Reynaldo
|
UPV Unit:
|
Universitat Politècnica de València. Instituto de Reconocimiento Molecular y Desarrollo Tecnológico - Institut de Reconeixement Molecular i Desenvolupament Tecnològic
Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials
|
Issued date:
|
|
Abstract:
|
[EN] This work describes the assembly of a novel enzyme-controlled nanomachine operated through an AND Boolean logic gate for on-command delivery. The nanodevice was constructed on Au-mesoporous silica Janus nanoparticles ...[+]
[EN] This work describes the assembly of a novel enzyme-controlled nanomachine operated through an AND Boolean logic gate for on-command delivery. The nanodevice was constructed on Au-mesoporous silica Janus nanoparticles capped with a thiol-sensitive gate-like molecular ensemble on the mesoporous face and functionalized with glutathione reductase on the gold face. This autonomous nanomachine employed NADPH and glutathione disulfide as input chemical signals, leading to the enzymatic production of reduced glutathione that causes the disruption of the gating mechanism on the mesoporous face and the consequent payload release as an output signal. The nanodevice was successfully used for the autonomous release of doxorubicin in HeLa cancer cells and RAW 264.7 macrophage cells.
[-]
|
Copyrigths:
|
Cerrado |
Source:
|
Nanoscale. (issn:
2040-3364
)
|
DOI:
|
10.1039/d0nr08282a
|
Publisher:
|
The Royal Society of Chemistry
|
Publisher version:
|
https://doi.org/10.1039/d0nr08282a
|
Project ID:
|
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2017-87954-P/ES/NANOMAQUINAS INTELIGENTES BASADAS EN NANOMATERIALES JANUS/
info:eu-repo/grantAgreement/GVA//PROMETEO%2F2018%2F024//Sistemas avanzados de liberación controlada/
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-100910-B-C41/ES/MATERIALES POROSOS INTELIGENTES MULTIFUNCIONALES Y DISPOSITIVOS ELECTRONICOS PARA LA LIBERACION DE FARMACOS, DETECCION DE DROGAS Y BIOMARCADORES Y COMUNICACION A NANOESCALA/
info:eu-repo/grantAgreement/MINECO//MAT2015-64139-C4-1-R/ES/NANOMATERIALES INTELIGENTES, SONDAS Y DISPOSITIVOS PARA EL DESARROLLO INTEGRADO DE NUEVAS HERRAMIENTAS APLICADAS AL CAMPO BIOMEDICO/
|
Thanks:
|
Financial support from the Spanish Ministry of Economy and Competitiveness (projects CTQ2017-87954-P, MAT2015-64139-C4-1 and RTI2018-100910-B-C41) is gratefully acknowledged. The authors also thank the Generalitat Valencia ...[+]
Financial support from the Spanish Ministry of Economy and Competitiveness (projects CTQ2017-87954-P, MAT2015-64139-C4-1 and RTI2018-100910-B-C41) is gratefully acknowledged. The authors also thank the Generalitat Valencia (Project PROMETEO/2018/024) for support.
[-]
|
Type:
|
Artículo
|