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dc.contributor.author | Pasin, Fabio![]() |
es_ES |
dc.contributor.author | Daròs, José-Antonio![]() |
es_ES |
dc.contributor.author | Tzanetakis, Ioannis E.![]() |
es_ES |
dc.date.accessioned | 2023-11-28T19:02:11Z | |
dc.date.available | 2023-11-28T19:02:11Z | |
dc.date.issued | 2022-07-01 | es_ES |
dc.identifier.issn | 0168-6445 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/200291 | |
dc.description.abstract | [EN] Potyviridae represents one of the most notable evolutionary radiations among RNA viruses; its species richness is accompanied by large genomic layout diversity and expansion of the encoded protein modules. Potyviridae, the largest family of known RNA viruses (realm Riboviria), belongs to the picorna-like supergroup and has important agricultural and ecological impacts. Potyvirid genomes are translated into polyproteins, which are in turn hydrolyzed to release mature products. Recent sequencing efforts revealed an unprecedented number of potyvirids with a rich variability in gene content and genomic layouts. Here, we review the heterogeneity of non-core modules that expand the structural and functional diversity of the potyvirid proteomes. We provide a family-wide classification of P1 proteinases into the functional Types A and B, and discuss pretty interesting sweet potato potyviral ORF (PISPO), putative zinc fingers, and alkylation B (AlkB)-non-core modules found within P1 cistrons. The atypical inosine triphosphate pyrophosphatase (ITPase/HAM1), as well as the pseudo tobacco mosaic virus-like coat protein (TMV-like CP) are discussed alongside homologs of unrelated virus taxa. Family-wide abundance of the multitasking helper component proteinase (HC-pro) is revised. Functional connections between non-core modules are highlighted to support host niche adaptation and immune evasion as main drivers of the Potyviridae evolutionary radiation. Potential biotechnological and synthetic biology applications of potyvirid leader proteinases and non-core modules are finally explored. | es_ES |
dc.description.sponsorship | FP is the recipient of a "Juan de la Cierva Incorporacion" contract [grant IJC2019-039970-I] from Ministerio de Ciencia e Innovacion (Spain). J-AD is funded by Ministerio de Ciencia e Innovacion (Spain), and co-financed by European Regional Development Fund [grant PID2020-114691RB-I00]. IET is funded from crop commodity boards, the berry and ornamental industry, the United States Department of Agriculture and the National Science Foundation (USA). | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | Oxford University Press | es_ES |
dc.relation.ispartof | FEMS Microbiology Reviews | es_ES |
dc.rights | Reconocimiento (by) | es_ES |
dc.subject | Potyviridae | es_ES |
dc.subject | Virus comparative genomics | es_ES |
dc.subject | Non-core proteome module | es_ES |
dc.subject | Evolutionary radiation | es_ES |
dc.subject | Host adaptation | es_ES |
dc.subject | Immune evasion | es_ES |
dc.title | Proteome expansion in the Potyviridae evolutionary radiation | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1093/femsre/fuac011 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-114691RB-I00/ES/BIOTECNOLOGIA DE VIRUS DE PLANTAS: VECTORES VIRALES Y ESTRATEGIAS DE RESISTENCIA/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MICINN//IJC2019-039970-I/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes | es_ES |
dc.description.bibliographicCitation | Pasin, F.; Daròs, J.; Tzanetakis, IE. (2022). Proteome expansion in the Potyviridae evolutionary radiation. FEMS Microbiology Reviews. 46(4):1-22. https://doi.org/10.1093/femsre/fuac011 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.1093/femsre/fuac011 | es_ES |
dc.description.upvformatpinicio | 1 | es_ES |
dc.description.upvformatpfin | 22 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 46 | es_ES |
dc.description.issue | 4 | es_ES |
dc.identifier.pmid | 35195244 | es_ES |
dc.identifier.pmcid | PMC9249622 | es_ES |
dc.relation.pasarela | S\487304 | es_ES |
dc.contributor.funder | Agencia Estatal de Investigación | es_ES |
dc.contributor.funder | National Science Foundation, EEUU | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación | es_ES |
dc.contributor.funder | United States Department of Agriculture, Agricultural Research Service | es_ES |