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dc.contributor.author | Capilla, A.![]() |
es_ES |
dc.contributor.author | Donat, E.![]() |
es_ES |
dc.contributor.author | Planelles, D.![]() |
es_ES |
dc.contributor.author | Espinós-Armero, Carmen Ángeles![]() |
es_ES |
dc.contributor.author | Ribes-Koninckx, C.![]() |
es_ES |
dc.contributor.author | Palau, F.![]() |
es_ES |
dc.date.accessioned | 2023-12-28T19:02:31Z | |
dc.date.available | 2023-12-28T19:02:31Z | |
dc.date.issued | 2007-10 | es_ES |
dc.identifier.issn | 0001-2815 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/201218 | |
dc.description.abstract | [EN] Genetic predisposition to celiac disease (CD) is determined primarily by the human leukocyte antigen (HLA) genes (CELIAC1 region; 6p21), although many loci are involved in disease susceptibility. First, we have analysed a large series of CD patients from the Spanish Mediterranean region who had previously been characterised for the HLA complex. We have investigated how relevant regions contribute to CD susceptibility: CELIAC3 (CD28/CTLA4/ICOS region on 2q33) and CELIAC4 (19p13) as well as the tumour necrosis factor alpha (TNF-alpha) and the linfotoxin loci by case-control and association analyses. We highlight the association with the +49*A allele of cytotoxic T-lymphocyte-associated antigen 4 locus (P = 0.01), and the -308*A of TNF-alpha locus (P = 0.0008) in DQ2 individuals, although an independent role for TNF-alpha as risk factor has not been proven. Moreover, we do not confirm the association with the CELIAC4 region polymorphisms described in other populations. | es_ES |
dc.description.sponsorship | We are grateful for the kind collaboration of patients and families and Asociación de Celíacos de la Comunidad Valenciana (ACECOVA). This work was supported by the Fondo de Investigacio¿n Sanitaria (grant PI02573) and by the CSIC Intramural Frontiers Project (PROFICEL). ED holds a fellowship from the Fundacio¿n La Fe. English text revised by F. Barraclough | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | Blackwell Publishing | es_ES |
dc.relation.ispartof | Tissue Antigens | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | Association analysis | es_ES |
dc.subject | Case-control study | es_ES |
dc.subject | Celiac disease | es_ES |
dc.subject | Spanish population | es_ES |
dc.subject | Transmission disequilibrium test | es_ES |
dc.subject.classification | BIOLOGIA CELULAR | es_ES |
dc.title | Genetic analyses of celiac disease in a Spanish population confirm association with CELIAC3 but not with CELIAC4 | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1111/j.1399-0039.2007.00899.x | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/CSIC//PROFICEL/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII//FIS PI02%2F573/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural - Escola Tècnica Superior d'Enginyeria Agronòmica i del Medi Natural | es_ES |
dc.description.bibliographicCitation | Capilla, A.; Donat, E.; Planelles, D.; Espinós-Armero, CÁ.; Ribes-Koninckx, C.; Palau, F. (2007). Genetic analyses of celiac disease in a Spanish population confirm association with CELIAC3 but not with CELIAC4. Tissue Antigens. 70(4):324-329. https://doi.org/10.1111/j.1399-0039.2007.00899.x | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.1111/j.1399-0039.2007.00899.x | es_ES |
dc.description.upvformatpinicio | 324 | es_ES |
dc.description.upvformatpfin | 329 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 70 | es_ES |
dc.description.issue | 4 | es_ES |
dc.identifier.pmid | 17767555 | es_ES |
dc.relation.pasarela | S\505746 | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Consejo Superior de Investigaciones Científicas | es_ES |