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Unveiling the Role of Key Parameters during Molecular Growth for Optimal Poly(glycerol sebacate) Synthesis

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Unveiling the Role of Key Parameters during Molecular Growth for Optimal Poly(glycerol sebacate) Synthesis

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dc.contributor.author Martín-Cabezuelo, Rubén es_ES
dc.contributor.author Naderpour-Penalver, Alicia es_ES
dc.contributor.author Sigen, A. es_ES
dc.contributor.author Wang, Wenxin es_ES
dc.contributor.author Vilariño-Feltrer, Guillermo es_ES
dc.contributor.author Vallés Lluch, Ana es_ES
dc.date.accessioned 2024-01-03T19:03:57Z
dc.date.available 2024-01-03T19:03:57Z
dc.date.issued 2023-10 es_ES
dc.identifier.issn 1438-7492 es_ES
dc.identifier.uri http://hdl.handle.net/10251/201420
dc.description.abstract [EN] Poly(glycerol sebacate) (PGS) belongs to the hyperbranched polyesters family (HBP), which possesses an extensive variety of applications due to its tunable chemical and mechanical properties, together with its biocompatibility and biodegradability. However, the understanding of PGS synthesis becomes a challenge due to the lack of consistency when determining its synthesis parameters. Understanding these parameters is fundamental to control PGS synthesis and obtain a scalable and reproducible final product for biomedical applications. To unveil their effect on diverging PGS properties, diols are used as glycerol analogs and the reaction is chemically and thermally monitored, suggesting a heterogeneous reactivity of the exposed hydroxyl groups. Also, confinement of the prepolymerization is proven to be fundamental In order to maintain the equimolar ratio of initial monomers during synthesis. Early stages of the polycondensation (first 4 h) tend to linear and less branched oligomers by consuming primary hydroxyls rather than secondary hydroxyls. However, physicochemical characterization determines that a high degree of conversion (40%) is reached during these early stages. Afterward, the oligomers tend to condense through the secondary hydroxyls into a more crosslinked elastomer. This study demonstrates how hydroxyl affinity, water presence, and glycerol loss are crucial for the scalability and reproducibility of its final product. es_ES
dc.description.sponsorship Grant PID2021-128213OB-I00 funded by MCIN/AEI/10.13039/501100011033 and by ERDF A way of making Europe. es_ES
dc.language Inglés es_ES
dc.publisher John Wiley & Sons es_ES
dc.relation.ispartof Macromolecular Materials and Engineering es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Biomaterials es_ES
dc.subject Glycerol es_ES
dc.subject H-NMR es_ES
dc.subject Poly(glycerol-sebacate) es_ES
dc.subject Polymer chemistry es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.subject.classification FISICA APLICADA es_ES
dc.title Unveiling the Role of Key Parameters during Molecular Growth for Optimal Poly(glycerol sebacate) Synthesis es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1002/mame.202300270 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI//PID2021-128213OB-I00//PARCHES DUALES PARA LA PIEL COMO PLATAFORMAS BI-FUNCIONALIZADAS CON PROPIEDADES TERAPÉUTICAS ANTIBACTERIANAS Y ANTIINFLAMATORIAS/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials es_ES
dc.description.bibliographicCitation Martín-Cabezuelo, R.; Naderpour-Penalver, A.; Sigen, A.; Wang, W.; Vilariño-Feltrer, G.; Vallés Lluch, A. (2023). Unveiling the Role of Key Parameters during Molecular Growth for Optimal Poly(glycerol sebacate) Synthesis. Macromolecular Materials and Engineering. https://doi.org/10.1002/mame.202300270 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1002/mame.202300270 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.relation.pasarela S\502856 es_ES
dc.contributor.funder AGENCIA ESTATAL DE INVESTIGACION es_ES
dc.contributor.funder European Regional Development Fund es_ES


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