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Cardiovascular Events During and After Bronchiectasis Exacerbations and Long-term Mortality

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Cardiovascular Events During and After Bronchiectasis Exacerbations and Long-term Mortality

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dc.contributor.author Méndez, Raúl es_ES
dc.contributor.author Feced, Laura es_ES
dc.contributor.author Alcaraz-Serrano,Victoria es_ES
dc.contributor.author González-Jiménez, Paula es_ES
dc.contributor.author Bouzas, Leyre es_ES
dc.contributor.author Alonso, Ricardo es_ES
dc.contributor.author Martínez-Dolz, Luis es_ES
dc.contributor.author Hervás-Marín, David es_ES
dc.contributor.author Fernández-Barat, Laia es_ES
dc.contributor.author Torres, Antoni es_ES
dc.contributor.author Menéndez, Rosario es_ES
dc.date.accessioned 2024-01-12T19:01:53Z
dc.date.available 2024-01-12T19:01:53Z
dc.date.issued 2022-03 es_ES
dc.identifier.issn 0012-3692 es_ES
dc.identifier.uri http://hdl.handle.net/10251/201889
dc.description.abstract [EN] BACKGROUND: Population-based and retrospective studies have shown that risk for cardiovascular events such as arrythmias, ischemic episodes, or heart failure, increase during and after bronchiectasis exacerbations. RESEARCH QUESTION: What are the risk factors for cardiovascular events (CVE) during and after bronchiectasis exacerbations and their impact on mortality? STUDY DESIGN AND METHODS: This was a post hoc retrospective analysis of a prospective observational study of 250 patients with bronchiectasis at two tertiary care hospitals. Only the first exacerbation was considered for each patient, collecting demographic, comorbidity, and severity data. The main outcomes were the appearance of CVE and mortality. Risk factors for CVE were analyzed using a semi-competing risks model. RESULTS: During a median follow-up of 35 months, 74 (29.6%) patients had a CVE and 93 (37.2%) died. Semi-competing risk analysis indicated that age, arterial hypertension, COPD, and potentially severe exacerbations significantly increased the risk for developing CVE. Compared with patients without CVE, those with CVE had higher mortality. INTERPRETATION: Demographic factors and comorbidities are risk factors for the development of CVE after an acute exacerbation of bronchiectasis. The appearance of CVE worsens long-term prognosis. es_ES
dc.description.sponsorship This study was supported by Sociedad Espanola de Neumologia y Cirugia Toracica (SEPAR [793/2018]) and Sociedad Valenciana de Neumologia (SVN [2018]). Raul Mendez is the recipient of a Rio Hortega grant supported by the Instituto de Salud Carlos III (ISCIII [CM19/00182]). Paula Gonzalez-Jimenez is the recipient of a Post-resident research grant supported by the Health Research Institute La Fe. es_ES
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof CHEST Journal es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Bronchiectasis es_ES
dc.subject Cardiovascular es_ES
dc.subject Exacerbations es_ES
dc.subject Mortality es_ES
dc.subject Proadrenomedullin es_ES
dc.subject.classification ESTADISTICA E INVESTIGACION OPERATIVA es_ES
dc.title Cardiovascular Events During and After Bronchiectasis Exacerbations and Long-term Mortality es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.chest.2021.10.013 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/ISCIII//CM19%2F00182/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/SEPAR//793%2F2018/ es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Politécnica Superior de Alcoy - Escola Politècnica Superior d'Alcoi es_ES
dc.description.bibliographicCitation Méndez, R.; Feced, L.; Alcaraz-Serrano, V.; González-Jiménez, P.; Bouzas, L.; Alonso, R.; Martínez-Dolz, L.... (2022). Cardiovascular Events During and After Bronchiectasis Exacerbations and Long-term Mortality. CHEST Journal. 161(3):629-636. https://doi.org/10.1016/j.chest.2021.10.013 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1016/j.chest.2021.10.013 es_ES
dc.description.upvformatpinicio 629 es_ES
dc.description.upvformatpfin 636 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 161 es_ES
dc.description.issue 3 es_ES
dc.identifier.pmid 34656526 es_ES
dc.relation.pasarela S\454736 es_ES
dc.contributor.funder Instituto de Salud Carlos III es_ES
dc.contributor.funder Sociedad Valenciana de Neumología es_ES
dc.contributor.funder Instituto de Investigación Sanitaria La Fe es_ES
dc.contributor.funder Sociedad Española de Neumología y Cirugía Torácica es_ES


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