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Targeted killing of prostate cancer cells using antibody¿drug conjugated carbon nanohorns.

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Targeted killing of prostate cancer cells using antibody¿drug conjugated carbon nanohorns.

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dc.contributor.author Lucío, María Isabel es_ES
dc.contributor.author Opri, Roberta es_ES
dc.contributor.author Pinto, Marcella es_ES
dc.contributor.author Scarsi, Alessia es_ES
dc.contributor.author Fierro, Jose L. G. es_ES
dc.contributor.author Meneghetti, Moreno es_ES
dc.contributor.author Fracasso, Giulio es_ES
dc.contributor.author Prato, Maurizio es_ES
dc.contributor.author Vázquez, Ester es_ES
dc.contributor.author Herrero, Maria Antonia es_ES
dc.date.accessioned 2024-01-17T19:02:30Z
dc.date.available 2024-01-17T19:02:30Z
dc.date.issued 2017-11-28 es_ES
dc.identifier.issn 2050-750X es_ES
dc.identifier.uri http://hdl.handle.net/10251/201979
dc.description.abstract [EN] The ability of carbon nanohorns (CNHs) to cross biological barriers makes them potential carriers for delivery purposes. In this work, we report the design of a new selective antibody¿drug nanosystem based on CNHs for the treatment of prostate cancer (PCa). In particular, cisplatin in a prodrug form and the monoclonal antibody (Ab) D2B, selective for PSMA+ cancer cells, have been attached to CNHs due to the current application of this antigen in PCa therapy. The hybrids Ab¿CNHs, cisplatin¿CNHs and functionalised-CNHs have also been synthesized to be used as control systems. The efficacy and specificity of the D2B¿cisplatin¿CNH conjugate to selectively target and kill PSMA+ prostate cancer cells have been demonstrated in comparison with other derivatives. The developed strategy to functionalise CNHs is fascinating because it can allow the fine tuning of both drug and Ab molecules attached to the nanostructure in order to modulate the activity of the nanosystem. Finally, the herein described methodology can be used for the incorporation of almost any drugs or Abs in the platforms in order to create new targeted drugs for the treatment of different diseases. es_ES
dc.description.sponsorship G. F. gratefully acknowledges Fondazione Cariverona, Verona Nanomedicine Initiative and Italian Minister of Health RF-2010-2305526 for supporting this work. M. M. thanks the University of Padova (P-DiSC #04BIRD2016-UNIPD). This work was also supported by the Spanish Ministry of Economy and Competitiveness MINECO (projects CTQ2014-53600-R and CTQ2016-76721-R), by the EU Graphene-based disruptive technologies, Flagship project (no. 696656). M. P., as the recipient of the AXA Chair, is grateful to the AXA Research Fund for financial support. M. P. was also supported by Diputacion Foral de Gipuzkoa program Red (101/16). es_ES
dc.language Inglés es_ES
dc.publisher The Royal Society of Chemistry es_ES
dc.relation.ispartof Journal of Materials Chemistry B es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject.classification QUIMICA ANALITICA es_ES
dc.title Targeted killing of prostate cancer cells using antibody¿drug conjugated carbon nanohorns. es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1039/C7TB02464A es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/696656/EU es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//CTQ2014-53600-R/ES/MATERIALES BASADOS EN GRAFENO COMO SISTEMAS PROGRAMABLES MULTI-ESTIMULO-RESPUESTA PARA LA LIBERACION CONTROLADA DE FARMACOS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//CTQ2016-76721-R/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/Diputación Foral de Gipuzkoa//101%2F16/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/Ministero della Salute//RF-2010-2305526/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural - Escola Tècnica Superior d'Enginyeria Agronòmica i del Medi Natural es_ES
dc.description.bibliographicCitation Lucío, MI.; Opri, R.; Pinto, M.; Scarsi, A.; Fierro, JLG.; Meneghetti, M.; Fracasso, G.... (2017). Targeted killing of prostate cancer cells using antibody¿drug conjugated carbon nanohorns. Journal of Materials Chemistry B. 5(44):8821-8832. https://doi.org/10.1039/C7TB02464A es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1039/C7TB02464A es_ES
dc.description.upvformatpinicio 8821 es_ES
dc.description.upvformatpfin 8832 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 5 es_ES
dc.description.issue 44 es_ES
dc.identifier.pmid 32264275 es_ES
dc.relation.pasarela S\384835 es_ES
dc.contributor.funder European Commission es_ES
dc.contributor.funder Ministero della Salute es_ES
dc.contributor.funder Diputación Foral de Gipuzkoa es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES


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