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dc.contributor.author | Tellechea-Luzardo, Jonathan Alexander | es_ES |
dc.contributor.author | Otero-Muras, Irene | es_ES |
dc.contributor.author | Goñi-Moreno, Angel | es_ES |
dc.contributor.author | Carbonell, Pablo | es_ES |
dc.date.accessioned | 2024-01-23T19:01:00Z | |
dc.date.available | 2024-01-23T19:01:00Z | |
dc.date.issued | 2022-07 | es_ES |
dc.identifier.issn | 0167-7799 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/202083 | |
dc.description.abstract | [EN] Biofoundries are highly automated facilities that enable the rapid and efficient design, build, test, and learn cycle of biomanufacturing and engineering biology, which is applicable to both research and industrial production. However, developing a biofoundry platform can be expensive and time consuming. A biofoundry should grow organically, starting from a basic platform but with a vision for automation, equipment interoperability, and efficiency. By thinking about strategies early in the process through process planning, simulation, and optimization, bottlenecks can be identified and resolved. Here, we provide a survey of technological solutions in biofoundries and their advantages and limitations. We explore possible pathways towards the creation of a functional, early-phase biofoundry, and strategies towards long-term sustainability. | es_ES |
dc.description.sponsorship | The authors thank Dr Rosalind Le Feuvre, Manchester SYNBIOCHEMCentre, for providing insightful discussions. J.T.-L. was supported by the Next Generation EU (NGEU) fund through the Spanish Recovery, Transformation and Resilience Plan via a Margarita Salas personal grant from the Spanish Ministry of Universities (UNI/551/2021). I.O.-M. was supported by CSIC intramural project PIE 20211CT006. A.G.-M. was supported by the grants BioSinT-CM (Y2020/TCS-6555) and CONTEXT (Atraccion de Talento Program; 2019-T1/BIO-14053) Projects of the Comunidad de Madrid, MULTI-SYSBIO (PID2020-117205GA-I00), and the Severo Ochoa Program for Centres of Excellence in R&D (SEV-2016-0672) (2017-2021) from MCIN/Agencia Estatal de Investigacion of Spain. P.C. was supported by MCIN/AEI/10.13039/501100011033 BIODYNAMICS grant number PID2020-117271RB-C21, and Universitat Politecnica de Valencia Talento Programme. | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation.ispartof | Trends in Biotechnology | es_ES |
dc.rights | Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) | es_ES |
dc.subject | Biofoundry | es_ES |
dc.subject | Laboratory automation | es_ES |
dc.subject | Engineering biology | es_ES |
dc.subject | Biocomputation | es_ES |
dc.subject.classification | INGENIERIA DE SISTEMAS Y AUTOMATICA | es_ES |
dc.title | Fast biofoundries: coping with the challenges of biomanufacturing | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1016/j.tibtech.2021.12.006 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-117205GA-I00/ES/IMPLEMENTAR RELACIONES SOCIALES EN SISTEMAS MULTICELULARES SINTETICOS PARA ALCANZAR BIOCOMPUTACIONES ROBUSTAS Y FIABLES / | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-117271RB-C21/ES/REGULACION DINAMICA MULTI-ESCALA EN INGENIERIA METABOLICA: CONTROL REALIMENTADO Y CICLO DBTL AUTOMATIZADO / | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/CAM//Y2020%2FTCS-6555//Ayudas para la realización de proyectos sinérgicos de I+D en nuevas y emergentes áreas científicas en la frontera de la ciencia y de naturaleza interdisciplinar/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/CAM//2019-T1%2FBIO-14053//Investigador/a Postdoctoral en Biología Sintética - Biología Molecular - Ingeniería Genética/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/CSIC//PIE 20211CT006/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MCIU//SEV-2016-0672/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MIU//UNI%2F551%2F2021//Subvenciones a universidades públicas para la recualificación del sistema universitario español/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials | es_ES |
dc.description.bibliographicCitation | Tellechea-Luzardo, JA.; Otero-Muras, I.; Goñi-Moreno, A.; Carbonell, P. (2022). Fast biofoundries: coping with the challenges of biomanufacturing. Trends in Biotechnology. 40(7):831-842. https://doi.org/10.1016/j.tibtech.2021.12.006 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.tibtech.2021.12.006 | es_ES |
dc.description.upvformatpinicio | 831 | es_ES |
dc.description.upvformatpfin | 842 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 40 | es_ES |
dc.description.issue | 7 | es_ES |
dc.identifier.pmid | 35012773 | es_ES |
dc.relation.pasarela | S\452945 | es_ES |
dc.contributor.funder | Comunidad de Madrid | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.contributor.funder | Ministerio de Universidades | es_ES |
dc.contributor.funder | Agencia Estatal de Investigación | es_ES |
dc.contributor.funder | Universitat Politècnica de València | es_ES |
dc.contributor.funder | Consejo Superior de Investigaciones Científicas | es_ES |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades | es_ES |
dc.subject.ods | 08.- Fomentar el crecimiento económico sostenido, inclusivo y sostenible, el empleo pleno y productivo, y el trabajo decente para todos | es_ES |